Those who know me, know I’m not someone who changes his preferences & behaviors lightly. As Ron Swanson said, “I regret nothing. The end.” Well, let me tell you about our new study, out from The Perry Lab @mskcancercenter.bsky.social in @cp-immunity.bsky.social, which is the exception. /1
🖨️ Hot off the press 🍾 :
I am super excited to share that our article on the host control of persistent EBV infection has just been published in Nature Magazine, in an accelerated article preview version:
rdcu.be/e4Lg8
Wellcome Connecting Science Single Cell Biology hybrid conference Conference dates: 10-12 June 2026 Location: Hinxton Hall Conference Centre, Wellcome Genome Campus, UK and online. Bursary deadline: 16 March 2026 Abstract deadline: 30 March 2026 In person registration deadline: 11 May 2026 Virtual registration deadline: 1 June 2026 Image of a conference delegate presenting a scientific poster.
Registration for Single Cell Biology 2026 is now open! #SingleCell26
Join us as we explore new single cell research insights and discoveries beyond the traditional model organisms🧬
🗓️ 10-12 June
📍 Wellcome Genome Campus, UK
Bursaries available
📎 bit.ly/4pyTK21
#SingleCell #Spatial #Genomics
Excited to share my first preprint on federated conditional analysis of rare single variant and aggregate association tests across six genetically-inferred ancestry groups in All of Us and UK Biobank doi.org/10.64898/202...
Preprint from @lpachter.bsky.social lab argues journals should treat results as machine-readable objects, not just PDFs. Narratives stay for humans, but claims, evidence, and evaluations should ship in structured form so machines can index and verify. www.biorxiv.org/content/10.6... 1/ 🧵
I feel like vegemite jokes are an untapped market wdyt @psmibert.bsky.social
Thanks for the enthusiastic support and charting the path 🙏
Re-analysis of human population-scale whole genome seq data elucidates genetic architecture of EBV DNA persistence, a framework for the broader human virome
@nature.com @caleblareau.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social @ryandhindsa.bsky.social
www.nature.com/articles/s41...
This was a fun and rewarding collaboration! A great example of extracting biological signal from data hiding in plain sight
There is also a wonderful summary of our work (including some important limitations) from Kristen Wade & Jill Hollenbach www.nature.com/articles/d41...
EBV infection is a major detriment to human health. @ryandhindsa.bsky.social, Slavé, and I discussed the impact of this work with @bloomberg.com and some future outlooks
www.bloomberg.com/news/article...
What's been particularly gratifying about this study is the corroboration by independent groups that have arrived at complementary conclusions. Those preprints are here:
www.medrxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.medrxiv.org/content/10.6...
Our prior thread digesting this work is available here. The key findings are the same from the preprint, but there's a boatload of new analyses for corroboration and interpretation of this new biomarker.
bsky.app/profile/cale...
Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection.
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
The Cancer Signaling & Microenvironment Program at Fox Chase Cancer Center is looking for tenure track faculty (assist./assoc./full) in computational & experimental protein design. CV & 3-page research statement by Feb 15.
More info here:
www.linkedin.com/feed/update/...
Questions: DM/Email me.
i see this all the time with no mention of structural suppression:
- Electoral College winner-take-all
- working day elections
- voter registration burden
turnout in battleground states is fairly high. people aren't lazy. they are responding to disincentivization and disenfranchisement.
We've summarized a detailed thread on this work over on X/Twitter (x.com/CalebLareau/...).
As newcomers to this protein design field, we’d very much welcome thoughts, feedback, missing citations, or ideas on how to steer this work next!
We are very excited to share the first preprint of a new direction for our group. Led by the fearless duo of @arthurwchow.bsky.social and @hoyinchu.bsky.social, our foray into computational protein design—
If you are able, please consider donating to our team’s effort. 100% of your donations support riot work for a cure! secure2.convio.net/mskcc/site/T...
I had an unbelievable first time running the NYC Marathon with
@fredsteammskcc.bsky.social and
@mskcancercenter.bsky.social! Shout out to the lab for supporting us!
Typical day in lab honestly
The squad 🍌🍌🍌
We have some BIG PLANS TONIGHT!!!
with @ronanchaligne.bsky.social @mskcancercenter.bsky.social
We're excited to share that Dr. Omar Abdel-Wahab, a leukemia specialist at MSK, has been elected to the @nam.edu.
With Dr. Abdel-Wahab’s appointment, a total of 28 MSK faculty members have been conferred with this recognition.
Congratulations, Dr. Abdel-Wahab!
bit.ly/49ezKw0
Zero arrests. 100,000 people. No violence. This who we are.
#nokings #nyc #weareallthefrog
Penn and USC have also rejected the Compact!
That makes 4 - stronger together.
www.insidehighered.com/news/faculty...
The data is from April but holy moly
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
Now that I'm settled in at @umasschan.bsky.social, I'm hiring at all levels: grad students, post-docs, and software engineers/bioinformaticians!
The goal of my lab is to understand the regulatory role of every nucleotide in our genomes and how this changes across every cell in our bodies.
