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Renato Polimanti

@renatopolimanti

Human Genetics, Molecular Epidemiology, Biological Psychiatry https://medicine.yale.edu/lab/polimanti/

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15.11.2024
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Latest posts by Renato Polimanti @renatopolimanti

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Ian McKellen performs “The Strangers’ Case” speech from “Sir Thomas More” on Colbert.

05.02.2026 13:07 👍 9249 🔁 3614 💬 177 📌 725
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Genomic Studies of Suicidal Thoughts and Behaviors in Latin American Populations: A Systematic Review Suicide is a leading cause of death globally, with disproportionately rising rates in Latin America. Despite increasing global interest in the biology of suicidal behavior, Latin American and…

"Genomic research on suicidality in Latin America is growing but remains fragmented and underpowered. Increasing representative sampling, implementing ancestry-aware methods, and fostering collaborations are essential to advance research and inform prevention strategies in these populations."

03.02.2026 13:00 👍 3 🔁 2 💬 0 📌 0
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Very excited to share our latest 📖 publication from the Latin American Genomics Consortium Suicide Working Group, now in press in @biologicalpsych.bsky.social, where we systematically review genomic 🧬 studies of suicidality in Latin American populations: linkinghub.elsevier.com/retrieve/pii...

19.01.2026 15:20 👍 6 🔁 3 💬 1 📌 0

Multivariate genome-wide association study of suicidal behaviors in >1.7 million individuals of diverse population descents https://www.medrxiv.org/content/10.64898/2025.12.15.25342298v1

16.12.2025 19:40 👍 1 🔁 2 💬 0 📌 0
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Notes from Beethoven’s genome Wesseldijk et al. compare the genomic information collected from Ludwig van Beethoven with population-based datasets used to quantify musical achievement.

With sequencing of Hitler's DNA making headlines, time for a reminder: analysing a polygenic score from a dead historically-significant figure won't give new insights into that person's behaviour. In a brief paper last year, we used Beethoven's genome to directly illustrate the fallacies involved.🧪👇

13.11.2025 11:25 👍 143 🔁 53 💬 2 📌 9
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Estimation and mapping of the missing heritability of human phenotypes - Nature WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 co...

First time on Bsky and first big announcement!

I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.

Our manuscript is here: www.nature.com/articles/s41....

12.11.2025 17:57 👍 218 🔁 70 💬 8 📌 5
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You attended the sessions; now it’s your turn to lead one at #ASHG26. Submit your Featured Symposium or Interactive Workshop proposal by January 20, 2026! We're looking for key breakthroughs in #AI, #GeneticCounseling, #PrecisionMedicine & more. 🔗 https://www.ashg.org/annual-meeting-2026/ #ASHG

10.11.2025 19:47 👍 3 🔁 3 💬 0 📌 0
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What we discovered during the #ASHG25 Featured Plenary Abstract Session III—the complexity of the human genome can be studied through many innovative approaches/tools, and there’s a need for more globally representative genomes and cohorts. #ASHG

17.10.2025 22:49 👍 13 🔁 5 💬 0 📌 0
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Day three of #ASHG25 is complete! ✔️

For today’s highlights we:
💡Soaked up insights from today’s scientific sessions
🏅Celebrated the excellence of our outstanding awardees
🔗Connected & collaborated with fellow attendees

See you tomorrow for day four!

17.10.2025 00:32 👍 6 🔁 2 💬 0 📌 0
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“We must keep going with this ability to sample genomes, not just in the convenient places we started out with.” - former Director of the National Institutes of Health, Francis Collins, MD, PhD, during his recognition speech at #ASHG25

14.10.2025 21:11 👍 21 🔁 9 💬 0 📌 0

Thanks to @geneticssociety.bsky.social, if you are coming early to #ASHG25 you can show your badge at the Boston Museum of Science and get in free! Stop by for your badge first and then head over if you are not going to any of the workshops, before Sarah Tishkoff’s presidential address at 4:30pm.

13.10.2025 13:40 👍 19 🔁 9 💬 0 📌 1
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⏰ TODAY at NOON ET, we’re giving you all the details you'll need to make your #ASHG25 experience in Boston one to beat! Join our webinar for:

✅Pro tips on navigating the event
✅Live Q&A
✅Must-have resources

Register now: learning.ashg.org/products/ash... @renatopolimanti.bsky.social #ASHG

01.10.2025 13:26 👍 2 🔁 3 💬 0 📌 0

Excited to share that our manuscript describing a multi-ancestry GWAS of nicotine dependence has now been published: doi.org/10.1017/S003...

20.08.2025 17:47 👍 20 🔁 4 💬 1 📌 0
Zero days left to save on registration rates to the ASHG 2025 Annual Meeting

Saving end today at 5 PM U.S. ET

Register Now! 

#ASHG25

Zero days left to save on registration rates to the ASHG 2025 Annual Meeting Saving end today at 5 PM U.S. ET Register Now! #ASHG25

🚨It’s now or never!

Today’s your last chance to save on the event bringing human genetics and genomics professionals together.

Don’t miss out—register before 5 PM U.S. ET: meetings.ashg.org/event/ASHG25...
#ASHG

06.08.2025 14:08 👍 2 🔁 1 💬 0 📌 0
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"A contextual genomic perspective on physical activity and its relationship to health, well being and illness" led by Marco Galimberti at @yaleschoolofmed.bsky.social and US Dept. of Veterans Affairs is now online at Nature Genetics (@natureportfolio.nature.com)

Link: www.nature.com/articles/s41...

21.07.2025 14:20 👍 6 🔁 2 💬 0 📌 0

‪Attending the @rsaofficial.bsky.social meeting in New Orleans? Be sure to check out some exciting work from members of the PGC-SUD working group:

21.06.2025 16:41 👍 3 🔁 3 💬 1 📌 0
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‪Attending the 2025 @behaviorgenetic.bsky.social Meeting in Atlanta? Be sure to check out some exciting work from members of the PGC-SUD working group:

21.06.2025 16:47 👍 5 🔁 2 💬 1 📌 0
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Latin America has experienced an increase in suicide rate, contrasting with a global decline. We review possible reasons for this here: www.sciencedirect.com/science/arti...
Led by Dr. Brenda Cabrera-Mendoza and @renatopolimanti.bsky.social, 1st publication from the LAGC Suicide Working Group.

17.06.2025 12:46 👍 6 🔁 6 💬 0 📌 0
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Sex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias INTRODUCTION Limited information is available regarding sex differences in the relationship of socioeconomic status and cognitive performance with Alzheimer's disease and related dementias (ADRD) fa...

🚨Our new study, led by Jun He, is out on ‪@alzdemjournals.bsky.social‬‬! Leveraging @ukbiobank.bsky.social and #AllofUs, we uncovered sex-specific effects of socioeconomic and cognitive factors on the assessment of #alzheimers family history.
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

27.05.2025 13:39 👍 1 🔁 0 💬 0 📌 0
ASHS Abstract Submission Process for the 2025 Annual Meeting

ASHS Abstract Submission Process for the 2025 Annual Meeting

ASHS Abstract Submission Process for the 2025 Annual Meeting

ASHS Abstract Submission Process for the 2025 Annual Meeting

Submitting an abstract for the first time or needing a refresher on the process? We've got you covered! When you submit an abstract to #ASHG25, you'll go from preparation to notification in just 6 steps.

📌Save this post for later
🔖Bookmark our website: www.ashg.org/meetings/202... #ASHG

16.05.2025 16:57 👍 3 🔁 4 💬 0 📌 0
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That's right – registration is open for #ASHG25!🧬Follow the link below to secure your spot and join us in Boston, MA for five days of scientific and industry excellence. We can't wait to see you there!

🎟️🔗 www.ashg.org/meetings/202... #ASHG #HumanGenetics

18.04.2025 17:51 👍 2 🔁 3 💬 0 📌 0
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Las experiencias traumáticas y la genética pueden aumentar el riesgo de endometriosis, según un nuevo estudio - Mujeres con ciencia Endometriosis. Experiencias traumáticas. Genética. Enfermedad inflamatoria crónica. Enfermedad sistémica.

Las experiencias traumáticas y la genética pueden aumentar el riesgo de endometriosis
👉 @dorakoller.bsky.social y @renatopolimanti.bsky.social 

18.04.2025 08:02 👍 5 🔁 4 💬 1 📌 0
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Mendelian Randomization for Causal Inference | Statistics Course This seminar by Renato Polimanti provides a comprehensive theoretical background regarding the integration of causal inference and human genetics.

Join "Mendelian Randomization for Causal Inference: Genetically Informed Causal Inference Through #MendelianRandomization and Other Approaches" with @renatopolimanti.bsky.social on April 9-11! Discover how genetic variation can uncover #causal relationships in large-scale datasets.

21.03.2025 13:27 👍 1 🔁 1 💬 0 📌 0
“Got polio? Me neither! I ❤️vaccines”

“Got polio? Me neither! I ❤️vaccines”

I love this photo that @melissabender.bsky.social captured of me at the #standupforscience rally yesterday in NYC. I wonder if I could make this my official faculty photo lol @jackiantonovich.bsky.social @kimberlywheiman.bsky.social @archaeoscape.bsky.social @sarahruncie.bsky.social

08.03.2025 12:50 👍 5566 🔁 854 💬 77 📌 23

Transgenic mice are widely used in cancer research to study tumor development, genetic mutations, and potential treatments. TRANSGENIC

06.03.2025 21:14 👍 4383 🔁 686 💬 183 📌 58

Understanding the comorbidities among psychiatric disorders, chronic low-back pain, and spinal degenerative disease using observational and genetically informed analyses https://www.medrxiv.org/content/10.1101/2025.02.28.25323099v1

05.03.2025 03:12 👍 1 🔁 1 💬 0 📌 0
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🔥Some Predictions about the NIH situation, NIH budget cuts
🔥 On March 14, the continuing resolution runs out that funds the US government (including NIH) through March 14.
🔥The government will shut down (no review panels, grant awards, Council meetings possible until it resumes) UNLESS ....👇🧵 (1/n)

01.03.2025 21:35 👍 11 🔁 6 💬 2 📌 0
Microsoft Forms

🚨PA colleagues:

"Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania."

"If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC

Get out your Other Support and share that info!

22.02.2025 20:12 👍 122 🔁 131 💬 4 📌 6
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Observational and Genetic Analyses of Traumatic Experiences and Endometriosis This case-control study analyzes genotypic and phenotypic information from individual-level UK Biobank data, along with genome-wide information from a large meta-analysis and the FinnGen cohort, to determine the relationship between traumatic experiences and endometriosis.

Women with endometriosis are more likely to experience childhood and adulthood traumas, independently of genetic predisposition.

by Koller D, Løkhammer S (...) Polimanti R et 8 al. in JAMA Psychiatry #MedSky

📖 read the article:

14.02.2025 06:35 👍 19 🔁 11 💬 0 📌 0
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Genetically defined population descriptors can reduce inaccuracies in research, but should they completely replace more conventional descriptors in the clinic?@ajhgnews.bsky.social latest article provides perspectives on this important genomic medicine topic: www.cell.com/ajhg/fulltex... #ASHG

07.02.2025 14:33 👍 8 🔁 2 💬 0 📌 0