Anders Sejr Hansen

Recently out: “Uniform dynamics of cohesin-mediated loop extrusion in living human cells”. In this study led by brilliant former PhD student Thomas Sabaté we use live cell microscopy and polymer simulations to characterize how DNA loops and TADs form in human cells by cohesin-driven extrusion. (1/4)

Exited to share Current Opinion review on how chromatin hubs involving multiple enhancers and promoters are formed, and their potential roles in gene regulation: www.sciencedirect.com/science/arti...

I had a lot of fun putting this together with @suminkim.bsky.social and @andersshansen.bsky.social! Glad to have had the chance to work on it!

Happy to share our new review on Polycomb-mediated 3D chromatin interactions! Thanks to @mileshuseyin.bsky.social and @andersshansen.bsky.social for great discussions throughout the process :)

Thanks also to @lucagiorgetti.bsky.social and @djost-physbiol.bsky.social for the invitation and for putting together a very interesting themed issue - the other reviews in the issue can be found here
www.sciencedirect.com/special-issu...

Excited to share @suminkim.bsky.social and @mileshuseyin.bsky.social 's new Current Opinion review on how Polycomb complexes mediate 3D genome interactions including mechanistic models and potential roles in gene regulation:
www.sciencedirect.com/science/arti...

Come on join us! We are searching for the next technical associate to join our lab ~Summer 2026.

This could be a great position for someone who is graduating this spring and is looking for 2 more years of research experience before starting their PhD:
careers.peopleclick.com/careerscp/cl...

🚨Preprint alert🚨 How does chromatin “architecture” form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos...

This was a serendipitous finding with so many involved (👀 @voslab.org and @andersshansen.bsky.social). Especially proud of Farnung Lab contributors @mosorio91.bsky.social (on the job market) and PhD candidate Alex Stone. Biochemistry, structural biology, and cell-based assays (Micro-C!!!).

Happy to share part of my postdoctoral work at the @lucas.farnunglab.com lab. Great collaboration with @voslab.org and @andersshansen.bsky.social. “Structural basis for CTCF-mediated chromatin organization” www.biorxiv.org/content/10.6...

🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...

Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in t...

New @science.org today
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...

Dynamics of microcompartment formation at the mitosis-to-G1 transition Nature Structural & Molecular Biology - Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and...

We co-submitted this article with the work of @andersshansen.bsky.social , @irate-physicist.bsky.social , and authors, who characterize similar cre microcompartments : rdcu.be/eWK1u

Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm Nature Cell Biology - Schooley et al. find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through...

Happy to share that my postdoc work with @jobdekker.bsky.social is out!
rdcu.be/eWHD2

We characterize interphase chromatin folding programs with distinct modes of mitotic inheritance and identify the chromosome-intrinsic capacity to form a microcompartment of active CREs during mitotic exit.

Happy #FluorescenceFriday! Meet our CCCTC-binding factor cell line and plasmid. It illuminates a binding site involved in transcription and is available for just the cost of shipping!

📦 @coriellinstitute.bsky.social and @addgene.bsky.social

Dynamics of microcompartment formation at the mitosis-to-G1 transition - Nature Structural & Molecular Biology Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and promoters in prometaphase. Polymer modeling in...

Be sure to also check out the great paper from @andersshansen.bsky.social and colleagues where they discover microcompartments on mitotic chromosomes using Region Capture Micro-C. Exciting times for those interested in chromosome conformation during cell division!
www.nature.com/articles/s41...

Inheriting chromosome conformation - Nature Cell Biology Chromosomes unfold and refold each time cells divide. A study by Schooley et al. demonstrates that chromosome-intrinsic and cytoplasmic factors uniquely contribute to interphase chromosome structure, with new possibilities for how gene expression programs are passed from mother cells to daughter cells.

Excited to share a News & Views highlighting a new, excellent paper from @jobdekker.bsky.social and @allanaschooley.bsky.social!
www.nature.com/articles/s41...

Dynamics of microcompartment formation at the mitosis-to-G1 transition - Nature Structural & Molecular Biology Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and promoters in prometaphase. Polymer modeling in...

See this recent paper by @andersshansen.bsky.social that discovers similar microcompartmentalization during mitotic exit:

www.nature.com/articles/s41...

Inheriting chromosome conformation - Nature Cell Biology Chromosomes unfold and refold each time cells divide. A study by Schooley et al. demonstrates that chromosome-intrinsic and cytoplasmic factors uniquely contribute to interphase chromosome structure, ...

And also see this nice News and Views by @kyleeagen.bsky.social

www.nature.com/articles/s41...

Congrats to @allanaschooley.bsky.social et al. @jobdekker.bsky.social on this beautiful paper, using a very elegant experimental system, to discover a chromosome intrinsic 3D genome folding program and microcompartmentalization of CREs at mitotic exit:

Region Capture Micro-C and 3D Genome Structure (Anders Sejr Hansen)

Excellent @activemotifusa.bsky.social epigenetics podcast w @andersshansen.bsky.social

It’s interesting, while going through specific projects and lines of questioning, the conversation acts as a nice reflection of the state of our field (fields?)

Lots of ideas!

open.spotify.com/episode/19Nd...

MIT professor Nuno Loureiro killed in shooting at his Brookline, Massachusetts home MIT professor Nuno F.G. Loureiro was killed in a shooting at his home in Brookline, Massachusetts.

An MIT lab director was killed in a shooting at his home in Brookline, Massachusetts Monday night, the school confirmed.

No one is in custody, Brookline police deputy superintendent said.

Our (Viraat Goel, @andersshansen.bsky.social et al) paper Dynamics of microcompartment formation during the M-to-G1 transition is in this month's @natsmb.nature.com -- thanks to NSMB editors and staff for the cover space and art! www.nature.com/nsmb/volumes...
See quoted posts for quick summary

SET1/MLL complexes control transcription independently of H3K4me3 Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...

An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!

www.biorxiv.org/content/10.6...

Absolutely fantastic Epigenetics and Genomics session on the latest frontiers of enhancer biology by @andersshansen.bsky.social, Martin Rivas and Mira Kassouf at the @ash.hematology.org annual meeting. Chaired by Megan McNerney.

Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀

Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function

now revised and journal accepted at www.science.org/doi/10.1126/...

🧵👇

Wonderful to see the beautiful preprint from Sabate et al now published - TADs are also dynamic structures in human cells, with remarkably similar parameters between mESCs and HCT116 cells
www.nature.com/articles/s41...

In this episode we talked with @andersshansen.bsky.social from MIT about his work on the impact of 3D genome structures on gene expression and advanced techniques like Region Capture Micro-C for mapping genome organisation. #podcast #epigenetics

Listen here: activemotif.com/podcasts-and...

Alternate proteins from the same gene contribute differently to health and rare disease | Whitehead Institute Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of rare disease, and present case studies of affected patients thro...

From an accidental discovery of hidden biology to a new framework to understanding and diagnosing rare disease. Thrilled to share the most recent work from our lab and the amazing Jimmy Ly.

wi.mit.edu/news/alterna...

🧬🔬🦠🧫🧪@science.org Escherichia coli with a 57-codon genetic code | Science www.science.org/doi/10.1126/...