The glycosyltransferase ALG3 is an AKT substrate that regulates protein N-glycosylation
AKT phosphorylates the glycosyltransferase ALG3. The PI3K/AKT signaling pathway is
frequently dysregulated in cancer and controls key cellular processes such as survival,
proliferation, metabolism, an...
Congratulations to the wonderfully-talented @adrijanavarro.bsky.social on her #JBC paper out today! We took a dive into the wonderful world of glycobiology, linking it to AKT and oncogene signaling in cancer. Brought to you by Toker Lab productions. @asbmbjournals.bsky.social
08.09.2025 23:25
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Alex Toker, Ludwig Harvard
YouTube video by Ludwig Cancer Research
Ludwig @harvard.edu’s @alextoker.bsky.social discusses his work, what drew him into a life of science and what compels him to contribute to cancer research.
youtu.be/IIG5VD8EHB8
#CancerResearch #CancerChat #ImmunoSky
07.01.2025 14:35
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Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
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25.11.2024 12:38
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Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer
Two FDA-approved compounds, AKT inhibitors and pitavastatin, synergize to induce cell death in triple-negative breast cancer, motivating evaluation of the efficacy of this combination in clinical tria...
Published a few weeks ago in Cancer Research, we show benefit of targeting HMCR with pitavastatin in combo with AKT inhibitors in TNBC. Many amazing people contributed, led by the magnificently talented @alissandra-hillis.bsky.social! Looking to initiate new clinical trials based on this combo. 🧪
20.11.2024 12:09
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It was such a pleasure to organize for Harry the Healer to come to our lab yesterday! Not only did he have the cutest badge, but his calming and healing nature were very helpful in rejuvenating spirits for all our hard working scientists!
20.11.2024 20:50
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