Nagaraj

Have been talking to many students in the last few weeks about this. I was curious about how volunteering is viewed and the impact this has.

Query : As a graduate student, how often are you involved in any volunteering work during your PhD ?

Often, Occasionally, Never?

None of this would have been possible but for the funding support for the study from ANRF (SERB) and IISER,Pune. Arnav was supported by a PMRF fellowship and Tushar by a DST INSPIRE Scholarship.

Golgi senses ECM stiffening in breast cancer cells Breast tumour progression is accompanied by extracellular matrix (ECM) stiffening, which remodels the cytoskeleton and promotes invasion. Here, Nagaraj Balasubramanian and colleagues (Saha et al., 202...

Thanks for highlighting this study @jcellsci.bsky.social
"This work links matrix stiffness sensing to Golgi organisation and function, revealing how the tumour microenvironment might promote breast cancer aggressiveness."
journals.biologists.com/jcs/article/...

Differential AXL expression and Arf1 regulation control stiffness-dependent Golgi organization in breast cancer cells Highlighted Article: An AXL-Arf1-Golgi signaling axis is a key mechanosensitive pathway that regulates Golgi organization and function, potentially linking matrix stiffness to tumor progression in bre...

Great to see this study from the lab now in print. The differential expression of AXL, and its regulation of Arf1 expression and activation, controls Golgi organization in breast cancer cells in a stiffness-dependent manner.

#matrix #mechanosensing #Golgi

journals.biologists.com/jcs/article/...

Wonderful to see work by Arnav Saha and Tushar Sherkhane from the lab featured on the cover of JCS @jcellsci.bsky.social. A wonderful collaboration between a PhD and UG Masters student to pull this amazing story off.

Thanks for the pick JCS

tinyurl.com/AXLGolgi

The abstract submission deadline for our upcoming 'Imaging Cell Dynamics' meeting is this Friday. We still have a few places remaining so apply now to secure your spot!

Find out more at:
www.biologists.com/meetings/jcs...

#imaging #microscopy #cellbiology

A much-delayed post, today being as good a day to share it. Jan 2026 saw Kajal and Debasmita defend their thesis and graduate. Its always incredible to look back and appreciate the journey. Congrajulations Kajal and Debasmita! @iiserpune

Good Luck with everything ahead !!

Thanks @biophysj.bsky.social for this cool cover to start our year. Image from the lab by Debasmita shows a wild-type mouse embryonic fibroblast treated with the ROCK inhibitor Y-27632 and embedded in a 1.0 mg/mL 3D collagen gel.

Link to MS - tinyurl.com/3Dcollagengel

Thanks @biophysj.bsky.social for this cool cover to start our year. Image from the lab by Debasmita shows a wild-type mouse embryonic fibroblast treated with the ROCK inhibitor Y-27632 and embedded in a 1.0 mg/mL 3D collagen gel.

Link to MS - tinyurl.com/3Dcollagengel

If there has to be a wish for the coming year, let it be this. May we all be students willing to learn.

Have an exciting, learning, inclusive 2026 !!

Jackson Lamb at his very best in #slowhorses Season 5 :-)

@rosariovalenti.bsky.social et al. created a proteome-wide yeast degron library for rapid in vivo protein depletion. This tool enables dynamic protein function studies with minimal cellular rewiring rupress.org/jcb/article/...

📕 From The Year In Cell Biology rupress.org/jcb/collecti...
#CellBio2025

Are you attending #CellBio2025 in Philadelphia? Visit us at Journal of Cell Biology Booth #1224 to chat about the journal, pick up a copy of The Year in Cell Biology: 2025 magazine 📕, and grab one of our exclusive puzzles 🧩

See The Year in Cell Biology: 2025 rupress.org/jcb/collecti...

If you haven't had the opportunity to take Prof. Subedhar's courses yet, there is one available on NPTEL that you might find valuable. This course could be beneficial no matter what stage of your career you're at. Be sure to check it out!
nptel.ac.in/courses/1021...

This semester saw Prof. Nishikant Subhedar teach his course one last time at IISER, Pune. An extraordinary teacher his course have stayed popular across generations of students. We had to raise a 🥂 to celebrate this exceptional career and person. Cheers to the next innings Sir!

Protein pattern morphology and dynamics emerging from effective interfacial tension - Nature Physics Protein patterns enable cellular processes. A general theory now identifies a non-equilibrium mechanism that generates an effective interfacial tension, shaping the geometry and intrinsic length scale...

www.nature.com/articles/s41...

Quite school libraries like this one at DLRC, Pune are to be cherished. Trying to get a Monday morning talk prepped waiting for kiddo to finish a game of soccer.

PhD students and Postdocs: The Night Science Podcast (@nightsciencepod.bsky.social) is producing an episode highlighting young scientists talking about their creative process. DM me if you'd like us to consider you for this, & read below what PhD student Davis Garner will contribute! ⬇️

Glad to see this in press @biophysj.bsky.social . Excellent work led by Debasmita at @IISERPune in collaboration with Shiva Patil's lab at @IISERPune and @MamoniDash lab at @ILS_Bhubaneswar. @ANRFIndia @cellpress.bsky.social

www.cell.com/biophysj/ful...

A mind map of the Bio101 course that introduces students to cells and their organization. Concepts from the course compiled by the class in the last lecture of the course @iiserpune. Insightful start to their cell bio journey at IISER,Pune.

Glad to see this in press @biophysj.bsky.social . Excellent work led by Debasmita at @IISERPune in collaboration with Shiva Patil's lab at @IISERPune and @MamoniDash lab at @ILS_Bhubaneswar. @ANRFIndia @cellpress.bsky.social

www.cell.com/biophysj/ful...

ATGC....DNA Anyone ?
buff.ly/j4e4i9f

Asgard makes an appearance in the evolutionary process. Bi1113 Model-building @IISERPune

Cytoskeleton reinterpreted. Bi1113 Model building. @IISERPune

Meosis 101. From clay to computers. To see these concepts come alive in 2D and 3-D models is amazing. @IISERPune @KundanSengupta

When the cellular organisation comes alive right down to the colour dipped ear bud lipid molecules, cytoskeleton and centrosome. This looks ready to mounted on the wall as a piece of art. @IISERPune

Like all years we host the Model Building sessions for the Bi1113 course at IISER,Pune. Organised by the TAs of the course this is a remarkable excercise in creativity and learning. Will share models put together in this thread. Details below.

Do join for this unique overnight concert on 8th evening, a great opportunity to listen to late night and early morning ragas which may not be too common in most concerts.

At IISER, Pune.
Open to All.

Paxillin’s nuclear switch: orchestrating gene splicing for brain plasticity | The EMBO Journal EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Interesting read...
"Activity-dependent phosphorylation of paxillin at serine 119 promotes its nuclear translocation, enabling it to fine-tune gene splicing programs critical for synaptic refinement during sensitive periods of brain development." @EMBOJ
buff.ly/bTEJvOQ

An introduction to the EMBO cytoskeleton meeting at @iiserpune and also the kit bag for the same by students as we kick the meeting off today. Looking forward to the same.