José Teles Reis

We just launched flyRoom — modern web-based stock management for Drosophila labs. No more spreadsheets, no more messy labels, no more lost stocks. Free to start, built by researchers for researchers.

www.flyroom.net

Happy to announce I've launched a new service for the fly community: flyRoom, a web-based comprehensive stock manager for all your fly pushing needs. Organise all your stocks, maps all your genotypes, plan your crosses, print and scan your labels. Give it a try and let your colleagues know!

Petsakou, A., Filine. E., Li, M., Zheng, A., and Perrimon, N. (2026) Tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms. Nature Communications. doi: 10.1038/s41467-026-70074-2. PMID: 41792134

FOMO is big from not being at #Dros26 !!!

Interclonal cooperation and suppression shape early Ras-driven tumour growth https://www.biorxiv.org/content/10.64898/2026.02.19.706761v1

GAL4, QF2, and LexA :-)

NF-κB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model Cancer-driving mutations cooperate with inflammatory cues in cancer progression, but exactly how remains unclear. This study unveils how oncogenic Ras engages inflammation to promote tumor progression...

Dillard, C., Teles-Reis, J., Jain, A., Antunes, M., Ruiz-Duran, P., Qi, Y., Le Borgne, R., Jasper, H., Rusten, T.. (2025). NF-kappaB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model.. PLoS Biol, 23(4):e3002663 journals.plos.org/plosbiology/...

Decoding the molecular logic of rapidly evolving ZAD zinc finger proteins in Drosophila Identification of ZAD-ZnF genes as key regulators of genome organization during Drosophila embryogenesis.

Diving into evolutionary biology! What is the origin of the most abundant class of insect transcription factors, ZAD-ZnFs? We suggest that they evolved from ancestral insulator-binding proteins that control 3D genome topology.

www.science.org/doi/10.1126/...

Keeping cells fit Fragments of aberrant cytoplasmic mRNA pair with nuclear RNAs to augment transcription

In a new Science study, researchers report on transcriptional adaptation, a dual feedback and feedforward mechanism that uses genetic redundancy to compensate for mutations in protein-coding genes.

Learn more in a new #SciencePerspective: https://scim.ag/4ryeXtN

Neuronal calcium spikes enable vector inversion in the Drosophila brain In the fly central complex, PFNa neurons switch from firing classical sodium spikes when depolarized to firing non-canonical T-type calcium spikes when hyperpolarized. This bidirectional spiking allow...

www.cell.com/cell/fulltex...

We had a lot of fun working on this project (led by Itzel Ishida, not on bluesky). Some interesting highlights from the paper -

So happy to share this in the middle of moving! Updates to our preprint looking at interactions between NOD2 and estrogen in zebrafish intestinal homeostasis, with truly outstanding work by Mckenna Eklund.

Join us for a day of talks, posters, and discussions, featuring a morning joint lecture with Nobel Laureates Eric F. Wieschaus and Christiane Nüsslein-Volhard!
Date: Monday, May 4th, 2026
Location: University of Copenhagen, Mærsk Tower
sites.google.com/view/emergin...
Free to participate

“Si no se investiga, no se avanza. Es una frase que se puede escribir en piedra.” - Mariano Barbacid

CytoTape in a neuron

Our CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...

Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila Adult intestinal plasticity and tissue repair involves complex and reciprocal multicellular interactions. Medina, Perochon, et al. report a signaling axis between hormone-producing cells in the intest...

Medina, A. B., Perochon, J., Tian, Y., Johnson, C. T., Holcombe, J., Ramesh, P., Polcownuk, S., Yu, Y., Cordero, J. B. (2025). Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila. Dev Cell, 60(22):3085-3101 www.cell.com/developmenta...

HIF-1α-mediated feedback prevents TOR signalling from depleting oxygen supply and triggering stress during normal development - Nature Communications During normal development, growing fly wing precursors become hypoxic, triggering HIF-1α-mediated negative feedback on TOR signalling and growth deceleration. Without this feedback, the mismatch betwe...

Zhao, Y., Alexandre, C., Kelly, G., Vincent, J. P., Perez-Mockus, G. (2025). HIF-1alpha-mediated feedback prevents TOR signalling from depleting oxygen supply and triggering stress during normal development. Nat Commun, www.nature.com/articles/s41...

Functional characterization of eicosanoid signaling in Drosophila development Author summary There are numerous bioactive lipids that control animal physiology, and some of them are commonly observed in both humans and insects. Well-studied insects such as fruit flies can there...

Fujinaga, D., Nolan, C., Yamanaka, N. (2025). Functional characterization of eicosanoid signaling in Drosophila development. PLoS Genet, 21(5):e1011705 journals.plos.org/plosgenetics...

Tumours aren’t just a messy mix of cells—they’re highly organised and hierarchical societies!
Just like in all societies, small chats between individuals can drive collective emergent behaviours - we reveal how these sustain tumour growth and cellular heterogeneity. 🧵👇

Photo of a cardboard sign in the snow that states “WE SAW THE VIDEO. WE KNOW THE TRUTH. ICE OUT.” in Minneapolis, Minnesota

📍 Minneapolis

Protesters in Los Angeles projected an anti-ICE video onto the Twin Towers, an ICE-linked detention facility where the Los Angeles Sheriff’s Department actively collaborates with ICE for deportation screenings.

@labcosta.bsky.social Out now in ScienceAdvances
our new work with @AndreaBassi78

MAcro Plant Projection Imaging (MAPPI): An open, scalable platform for whole-plant fluorescence real-time imaging | Science Advances science.org/doi/10.1126/...

I am excited to share our review that was published in Molecular Oncology @moloncology.bsky.social entitled "Tumour–host interactions in Drosophila: mechanisms in the tumour micro- and macroenvironment"
febs.onlinelibrary.wiley.com/doi/10.1002/...

Wondering what to study for the next three years?
Applications for the PhD programme are now open!
igdr.univ-rennes.fr/concours-doc...
Our team is offering two projects, one on tumour-innate immune system dialogue and the other on collective cell migration and organogenesis.

a cartoon of a person reading a book that says i want to read all the books ALT: a cartoon of a person reading a book that says i want to read all the books

We had a great time writing this review. The quality of the work of all the labs in this field is truly impressive.

We hope this review can slide into your reading queue !

In this review we synthesize how Drosophila genetics has been making BIG steps in our understanding of the tumour micro- and macroenvironment. From local cell competition and immune crosstalk to organism-wide metabolic and physiological collapse.

Cancer is not just a cell-intrinsic disease. It is shaped by a constant dialogue between tumours and the host.

Understanding cancer therefore requires models that capture whole-organism complexity while allowing precise genetic dissection of tumour-host crosstalk.

I am excited to share our review that was published in Molecular Oncology @moloncology.bsky.social entitled "Tumour–host interactions in Drosophila: mechanisms in the tumour micro- and macroenvironment"
febs.onlinelibrary.wiley.com/doi/10.1002/...

The December #TechnicalAdvances are here! If you want your paper with a new technique , reagent, or resource featured in an upcoming update, make sure to flag it when you #FTYP!
wiki.flybase.org/wiki/FlyBase...

I was in awe when I saw this presented at the fly meeting. Can't wait to dig in. Fly power!!! @neurogut.bsky.social @drosostalis.bsky.social @irenemiguel-aliaga.bsky.social

Hot stuff! 🔥🔥🔥