Arnaud Machelart

Very happy to share our group’s second publication this month!
In this work, we investigate the intrinsic anti-tuberculosis activity of polymeric β-cyclodextrin nanoparticles.
Proud of the team’s efforts!

Selective accumulation of nanoparticles in infected cells for targeted drug delivery In response to the escalating threat of infectious diseases and antimicrobial resistance, novel therapeutic strategies are under active development. A…

🚀Thrilled to announce our latest publication in Journal of Controlled Release!
Our team reveals a key property of antimicrobial nanovectors in the fight against infectious diseases.
🎉🔬
www.sciencedirect.com/science/arti...

Selective accumulation of nanoparticles in infected cells for targeted drug delivery In response to the escalating threat of infectious diseases and antimicrobial resistance, novel therapeutic strategies are under active development. A…

📢 A new pub in Journal of Controlled Release by Dr @arnaudmachelart.bsky.social group and Dr Ruxandra Gref team

“Selective accumulation of nanoparticles in infected cells for targeted drug delivery”

@inserm.fr @cnrs-hautsdefrance.bsky.social @rechercheulille.bsky.social @pasteurlille.bsky.social

Ravis d’accueillir le public pour les Journées Européennes du Patrimoine à l’Institut Pasteur de Lille ! 🧬
Notre équipe passionnée a présenté nos travaux sur la tuberculose.
Merci à tous pour cette belle journée ! 👏

The @ciilofficiel.bsky.social team is at #IUIS2025 in Vienna! N. Mielcarek on BPZE1 pertussis vaccine, E. Hoffmann on ERA4TB drug testing, while @joanfine.bsky.social , I. Leleu, @vsencio.bsky.social & @arnaudmachelart.bsky.social are showcasing their work in poster sessions.
#Immunology

🦠✨ Exciting science at #IUIS2025 in Vienna!
Don’t miss posters on host–pathogen interactions by:
🔹 #338 Joan Fine
🔹 #342 Valentin Sencio
🔹 #347 Ines Leleu

Amine Pochet, Yoel Dagan, Ernesto Anoz Carbonell, Vien Quang Tri Ho, Arnaud Machelart, Zainab Edoo, Ruben C. Hartkoorn, Nicolas Willand, Oriane Rivière, Axelle Grandé, Alain Baulard

Institut @pasteurlille.bsky.social teams joined the GRC #TB Drug Discovery and Dev. to present their latest work. With rising resistance and 1.5M deaths/year, better TB treatments are urgent. A week of fruitful talks & new collaborations!

@hartkoorn-lab.bsky.social @arnaudmachelart.bsky.social

Beta-cyclodextrins in infectious disease therapy: A review of their function beyond simple drug carriers Cyclodextrins (CDs) are cyclic oligosaccharides derived from starch through enzymatic conversion. Over the past decades, CDs and their derivatives (dC…

🚨 New review from our group!
PhD student Amine Pochet dives into the use of cyclodextrins beyond drug delivery — as active agents against infectious diseases.
@ciilofficiel.bsky.social @pasteurlille.bsky.social @inserm.fr @univlille.bsky.social

www.sciencedirect.com/science/arti...

À l’Institut Pasteur de Lille, le Dr F. Real et son équipe (@ciilofficiel.bsky.social) montrent que le #VIH infecte les mégacaryocytes en réduisant IFITM3, une protéine antivirale. Ces cellules pourraient former un réservoir viral caché, empêchant de parvenir à une guérison du VIH ➡️ bit.ly/3FSMc8C

Pulmonary delivery of clofoctol-loaded nanoparticles inhibits SARS-CoV-2 replication and reduces pneumonia Despite the progress made through vaccination campaigns and the use of antivirals, the need for more effective therapeutics to combat respiratory vira…

Excited to share our latest work on incorporating an antiviral molecule into delivery vectors to target pulmonary infections. 🍃🦠
www.sciencedirect.com/science/arti...

Rencontre avec Laurye Van Maele, chercheuse à l’Institut Pasteur de Lille Laurye Van Maele est chercheuse à l’Institut Pasteur de Lille. Melye, en stage che...

🎤 Laurye Van Maele, chercheuse
@inserm.fr au @ciilofficiel.bsky.social à l'Institut Pasteur de Lille, a joué le jeu de l’interview menée par une élève de 3e pour “Ta voix », le media jeune de @lavoixdunord.fr. Une belle rencontre intergénérationnelle autour de la #recherche 👉 bit.ly/4k3D2o1

À l’Institut Pasteur de Lille, l’équipe du Dr François Trottein au @ciilofficiel.bsky.social montre qu’un microbiote intestinal déséquilibré chez les aînés aggrave le #COVID19. Probiotiques et prébiotiques pourraient améliorer la récupération 👉 pasteur-lille.fr/2025/04/16/m...

Pulmonary delivery of clofoctol-loaded nanoparticles inhibits SARS-CoV-2 replication and reduces pneumonia Despite the progress made through vaccination campaigns and the use of antivirals, the need for more effective therapeutics to combat respiratory vira…

🚨New Pub🚨 #PulmonaryDelivery of clofoctol-loaded #Nanoparticles inhibits #SARSCoV2 replication and reduces pneumonia 💥 Study co-led by Drs Brodin, Trottein, Machelart ( @arnaudmachelart.bsky.social ) & Dr. R. Gref ( @ismolab.bsky.social ) | Institut des Sciences Moléculaires d'Orsay

Réchauffement climatique et maladies tropicales : quels sont les liens ? - Arnaud Machelart - 10' #3 YouTube video by Pasteur Lille

@arnaudmachelart.bsky.social , chercheur @inserm.fr

Comment le #réchauffement #climatique favorise-t-il l’ #émergence des maladies tropicales ?

L’antibiorésistance : quel danger pour l’environnement et notre santé ? - 10' de Prév' YouTube video by Pasteur Lille

@arnaudmachelart.bsky.social , chercheur @inserm.fr avec les doctorants Axelle Grandé et Amine Pauchet @univlille.bsky.social

L’ #antibiorésistance, une bombe à retardement ?

Conférences Envie de Savoir(s) dans le cadre des Printemps de la Prev' 2025 YouTube video by Pasteur Lille

Réchauffement climatique et maladies infectieuses émergentes : (re)découvrez la conférence de nos chercheurs @inserm.fr @cnrs-hautsdefrance.bsky.social

Dr A. Machelart @arnaudmachelart.bsky.social
Dr M. Gissot. @gissotlab.bsky.social
Dr S. Pied
Dr S. Bontemps-Gallo @sebbontempsgallo.bsky.social

Excited to introduce our (expanded) research group for 2025!

I am happy to have participated in the @anrs-mie.bsky.social Start Day. Young researchers have talent too!

24 mars, journée mondiale de lutte contre la #tuberculose ! À l’Institut Pasteur de Lille, Albert Calmette et Camille Guérin ont créé le BCG en 1921. Plus de 130 ans plus tard, nos chercheurs poursuivent cet héritage et continuent de lutter contre cette maladie mondiale 👉 bit.ly/4iFrsiS
#EndTB.

Colloque I3M at Strasbourg! @joanfine.bsky.social @vsencio.bsky.social

#StandUpforScience 2025 – Because science is a common good. The @ciilofficiel.bsky.social was present alongside all colleagues on the @pasteurlille.bsky.social campus. #ScienceForAll
@cnrs-hautsdefrance.bsky.social @inserm.fr @chulille.bsky.social @univlille.bsky.social

🔴 Women scientists at @ciilofficiel.bsky.social were joined by their colleagues from @pasteurlille.bsky.social, all dressed in red for the #Coquelicots initiative on #InternationalWomensDay

Women in science exist! Let’s be visible: wear red & form a vast poppy field from the sky! 🌍🔬

📣 Stand Up for Science 2025 à l'Institut Pasteur de Lille parce que la science est un bien commun. 📣

Plus d'infos sur le mouvement 👉 standupforscience.fr

#pasteurlille

Bravo Joan! @joanfine.bsky.social

#FluorescenceFriday The macrophage (nucleus in blue) protein Tirap (in red) is recruited to the Mycobacterium tuberculosis (in green)-containing vacuole.
This recruitment is essential to enable bacterial replication.
Belhaouane et al. PLoS Pathogens 2023

The Center for Infection and Immunity of Lille (CIIL) is now on Bluesky !

📢 Follow us for updates on our latest research, collaborations, and breakthroughs in #infectious #diseases, #immunology, and #microbiology.

📍 Follow us here: @ciilofficiel.bsky.social

Rev-erb-α antagonism in alveolar macrophages protects against pneumococcal infection in elderly mice Silva Angulo et al. provide insights into mechanisms underlying respiratory bacterial susceptibility in the elderly. The authors demonstrate that the altered circadian expression of the nuclear recept...

Rev-erb-α antagonism in alveolar macrophages protects against pneumococcal infection in elderly mice: Cell Reports www.cell.com/cell-reports...

🦠 How does #Tuberculosis survive the journey through the air?
New research from C. Nathan’s lab shows that Mtb actively resists desiccation, remodeling its transcriptome and using anti-desiccant proteins to endure aerosolization!

#InfectiousDisease #MycroSky #TBSky

www.biorxiv.org/content/10.1...

Tuberculosis Is Back—Just in Time for Trump to Make Things Even Worse State officials say the U.S. is suffering its largest documented TB outbreak in history. Meanwhile, Trump is busy gutting health programs.

The state of Kansas is experiencing a massive tuberculosis outbreak, just as the Trump administration has ordered the Centers for Disease Control and Prevention and the National Institutes of Health to cease communications with the public.

https://newrepublic.com/post/190797/tuberculosis-outbreak-…

Kansas tuberculosis outbreak now largest in US Sixty-seven active TB cases and 79 latent TB cases have been reported in 2 Kansas counties since the beginning of 2024.

A tuberculosis (TB) outbreak in Kansas City has become the largest documented TB outbreak on record in the United States.

www.cidrap.umn.edu/tuberculosis...