Excited to see work led by @autophazeke.bsky.social, @minghaochen.bsky.social, Thanh Nguyen, and Ainara Claveras out in @science.org today, the culmination of a 15-year project to understand structurally how the synthesis of the critical lipid of autophagy, PI3P, is regulated. tinyurl.com/ywvjh8u4
our first serious attempt to understand F-actin (F standing for filamentous, among other things) in Aspergillus nidulans: www.biorxiv.org/content/10.1...
and if you don't believe me, please do read the last page of this book
Garrod's book was published in 1931, at the time that the Spanish Republic was being proclaimed. The concept of genetic susceptibility to disease is in the pages of this hidden Jewel. As so often happens these days, we are reinventing the wheel. Compulsory reading for med & biol professionals
my first post in this network will be to honor Archibald Garrod, one of the forefathers (arguably the most ignored) of modern genetics.
