New preprint out!
In this study, we introduce NanoFLex, a strategy that combines #HaloTag variants with #nanobodies -based immunolabeling to enable rapid, OneStep-IF #lifetime #multiplexing. Possible due to SmartSecondaries fused to #HaloTag from @nanotag.bsky.social: www.biorxiv.org/content/10.6...
Latest from the lab, led by @ara-donia.bsky.social and @juliavdkorput.bsky.social
Huge team effort, with immense contributions by friends from nearby and around the globe.
www.science.org/doi/10.1126/...
If you're interested in the factors that enable the regular structure of CNS #myelin sheaths by #oligodendrocytes, check this out. Featuring a #CDC42 - effector proteins - #septin axis. Congrats to 1st author Sophie, and a big thank you to all who contributed
onlinelibrary.wiley.com/doi/10.1002/...
This nice paper adds cows to the list of species using tools
Well, it’s also good news for the community. My congratulations!
Looking forward to reading this. My congratulations, Noa and the entire team!
Long overdue…. My congratulations!
Looks like a very nice place for thinking about or discussing our projects...
If you’re interested in #neurodevelopmental disorders, or the transcriptional network regulating #myelin, or both, check this out. Congratulations Gilad and @barakboaz.bsky.social. I’m happy that we were able to contribute a tiny bit!
If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed!
www.biorxiv.org/content/10.1...
My congratulations; I'm certain the project will be a success
Oh, me too
During the symposium @amsterdamleuko.bsky.social, I learned that lifespan and quality of life have improved because caregivers now know better how to support #leukodystrophy patients. If that’s not a cause worth spending a scientific career on, I don’t know what is. Congratulations, Marjo!
Leukodystrophies are rare, severe brain disorders. It’s remarkable how much the field has progressed, from identifying disease genes and understanding some of the disease mechanisms to therapy, quite a bit of that owing to Marjos work @amsterdamleuko.bsky.social
Yesterday in Amsterdam, Marjo van der Knaap gave her retirement lecture at @vuamsterdam.bsky.social. An international group of scientists working on #leukodystrophies paid respect to her achievements, including by wearing the traditional gown. There was also a good party @amsterdamleuko.bsky.social
It’s years since I did #leukodystrophy research, so I’m looking forward to the updates I'll get in the next 2 days symposium @amsterdamleuko.bsky.social. We‘ll also celebrate the achievements of Marjo van der Knaap, who will retire soon.
Leaving Edinburgh and the peripheral nerve society meeting with lots of impressions of how much the science in this field has advanced in the last few years, and how basic science ultimately results in therapy approaches for neuropathies. Takes years but is very much worth it.
I‘m looking forward to the next days when I’m in Edinburgh to learn about the newest research on the peripheral nervous system at pnsociety.com/2025-pns-ann...
If you're interested in new tools for #myelin research, here come anti-CNP #nanobodies. Congratulations to Petri Kursula, Felipe Opazo and the entire team! For structural, cell biology, and imaging data see
www.biorxiv.org/content/10.1101/2024.05.25.595513v1
This interesting paper establishes zebrafish as a model to assess diameters of myelinated axons and their relevance for the speed of nerve conduction. Great work from Dave Lyons and his team in Edinburgh
www.nature.com/articles/s41...
This Thursday, interesting talk in the Forum Wissen in Göttingen
If you're looking for a current, practical overview about fluorescent imaging at very high resolution, here it is
www.sciencedirect.com/science/article/pii/S0962892423002398?via%3Dihub
If you’re interested in #axon/#glia interaction and #myelin, have a look at this interesting paper. My congratulations Zoe and Aiman to this great work. I’m glad that we were able to contribute a tiny bit
www.nature.com/articles/s41...
