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Pugh Lab

@pughlab

Translational Cancer Genomics Lab | Dr. Trevor Pugh, PhD, FACMG | Single-cell Genomics. Immunogenomics. Cell-free DNA. | Toronto, Ontario, Canada

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17.11.2024
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Latest posts by Pugh Lab @pughlab

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Exciting new research in advanced melanoma shows sequencing T-cells can help predict and monitor response to adoptive cell transfer, a treatment using a patient’s own immune cells to attack cancer. @uhnresearch.ca @uhn.ca @oicr.on.ca
doi.org/10.1186/s130...

24.02.2026 15:57 πŸ‘ 5 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection - Nature Cancer Zeng et al. analyzed cfDNA methylation and fragmentomic data from 1,294 patient plasma samples across 14 major cancer types to present a comprehensive landscape of pancancer and cancer-specific cell-f...

🌟New Resource article

Read about the pancancer landscape of cancer-specific cell-free DNA methylation and fragmentomic features from plasma samples from 1,294 patients

βœ’οΈYong Zeng, @matlupien.bsky.social, @pughlab.bsky.social, Housheng Hansen He & colleagues

www.nature.com/articles/s43...

19.02.2026 14:15 πŸ‘ 4 πŸ” 3 πŸ’¬ 0 πŸ“Œ 1
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A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection - Nature Cancer Zeng et al. analyzed cfDNA methylation and fragmentomic data from 1,294 patient plasma samples across 14 major cancer types to present a comprehensive landscape of pancancer and cancer-specific cell-f...

Massive team-science effort across @pmresearch-uhn.bsky.social @uhnresearch.ca @uhn.ca @oicr.on.ca and collaborators (incl. TrevorPugh & Hansen He labs; lead author Yong Zeng).
www.nature.com/articles/s43...

19.02.2026 14:14 πŸ‘ 6 πŸ” 1 πŸ’¬ 2 πŸ“Œ 1
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πŸπŸ”¬MOHCCN Clinician Scientist Awards 2026 LaunchπŸπŸ”¬

The MOHCCN Clinician Scientist Awards provide funding to young investigators looking to conduct high-quality, clinically-related research in precision oncology.

Letter of Intent due: January 22, 2026

Learn more: tinyurl.com/dn774xa5

11.12.2025 21:35 πŸ‘ 8 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Today is a great day for cancer research in Canada and, more importantly, for the health of all Canadians! We sincerely thank the Government of Canada for its ongoing commitment to improve the lives of Canadians diagnosed with cancer through the work of the Network.

Full statement ▢️ bit.ly/4oSuFhp

04.11.2025 22:25 πŸ‘ 7 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1
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πŸŽ‰ Congratulations to LTRI alumna Dr. Mary Brunkow on receiving the 2025 Nobel Prize in Physiology or Medicine for her groundbreaking immune system research.

Read the story: www.sinaihealth.ca/news/ltri-al...

06.10.2025 19:16 πŸ‘ 4 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Image of Toronto

Image of Toronto

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

28.08.2025 06:34 πŸ‘ 133 πŸ” 169 πŸ’¬ 0 πŸ“Œ 8
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Mark your calendar with #CGCAnnual2026β€”we look forward to seeing you in Houston next year!ο»Ώ

#CGCAnnual2026 #genomics #cancer #research #genetics #clinicaltesting #bioinformatics #cytogenetics #molecular

25.08.2025 19:00 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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’We couldn’t live without it’: the UCSC Genome Browser turns 25 After a quarter of a century, the website remains an essential tool for navigating the genome and understanding its structure, function and clinical impact.

After a quarter of a century, the UCSC Genome Browser remains an essential tool for navigating the genome and understanding its structure, function and clinical impact

https://go.nature.com/40wPxkB

30.06.2025 11:49 πŸ‘ 79 πŸ” 32 πŸ’¬ 0 πŸ“Œ 7
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2024 Morris F. Collen Award Winner - Atul Butte, MD, PhD, FACMI This is "2024 Morris F. Collen Award Winner - Atul Butte, MD, PhD, FACMI" by AMIA on Vimeo, the home for high quality videos and the people who love them.

For those of you who may not have known him, Dr. Atul Butte, a pioneer in informatics, was the winner of the 2024 Morris F. Collen award, a pinnacle achievement in our field, as part of his storied career.

His passing is a major loss to us all.

RIP Dr. Butte

#MedSky

14.06.2025 13:59 πŸ‘ 34 πŸ” 11 πŸ’¬ 4 πŸ“Œ 1

Excited to share our first lab paper, now published in Developmental Cell @cellpress.bsky.social !

🧠 How do glioblastoma (GBM) cells invade the brain, and what enables them to spread so effectively?

16.05.2025 15:47 πŸ‘ 15 πŸ” 4 πŸ’¬ 2 πŸ“Œ 1

Cell therapy has revolutionized cancer treatment. Now, its potential is expanding far beyond.

Join us for the launch of the Centre for Immunology to Immunotherapy at UHN to explore the future of cell therapy:
events.myconferencesuite.com/Ci2iSymposiu...

12.05.2025 13:01 πŸ‘ 9 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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Clonal Hematopoiesis as a Driver of Solid Tumors | NEJM Clonal hematopoiesis is the expansion of a genetically related population of hematopoietic stem and progenitor cells that disproportionately contribute to blood-cell production.1 Clonal hematopoies...

New evidence @nejm.org today that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....

23.04.2025 22:22 πŸ‘ 140 πŸ” 34 πŸ’¬ 3 πŸ“Œ 1
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Opinion: Canada can be the global leader in medical research As the U.S. slashes funding to its research initiatives, there is a chance for us to recruit the best talent from around the world

It's time for Canada to Lead

www.theglobeandmail.com/opinion/arti...

18.04.2025 14:57 πŸ‘ 15 πŸ” 7 πŸ’¬ 0 πŸ“Œ 1
An illustrated diagram of the biologic features of extrachromosomal DNAs

An illustrated diagram of the biologic features of extrachromosomal DNAs

A recent study shows how extrachromosomal DNA contributes to tumor heterogeneity and may drive cancer progression. Learn more: nej.md/42jfYdH

#MedSky #Oncology #Genetics

13.04.2025 13:01 πŸ‘ 24 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0
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The Allan Slaight Breakthrough Forum brought together 60+ scientists from Princess Margaret Cancer Centre, Krembil Research Institute, and CAMH to explore the links between cancer, neuroscience, & mental health. Looking forward to the exciting discoveries ahead!

www.uhnresearch.ca/news/advanci...

04.04.2025 14:12 πŸ‘ 5 πŸ” 3 πŸ’¬ 1 πŸ“Œ 1
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Canada’s U.S. brain gain is risky without more foundational support for science Scientists want to come to Canada not only to escape the chaos and uncertainty emerging in U.S. science but also because they are drawn to the energy here

Excellent Op-Ed by Peter Zandstra on improving πŸ‡¨πŸ‡¦ science at a time when πŸ‡ΊπŸ‡Έ is throttling their golden goose. Instead of bespoke, targeted & ultimately short term solutions limited to a few people, build a deep, more attractive ecosysyem. The best will thrive. www.theglobeandmail.com/gift/46242ee...

03.04.2025 19:36 πŸ‘ 60 πŸ” 28 πŸ’¬ 2 πŸ“Œ 3

We're excited to join Bluesky! Follow us for the latest news about cBioPortal.

10.03.2025 19:38 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Welcome to the March 2025 edition of the cBioPortal Newsletter! As we step into 2025, we're excited to share the latest updates and enhancements in cBioPortal. cBioPortal is hosting Google Summer of Code (GSoC) 2025 We are excited to announce that cBioPortal has o...

First newsletter of 2025! Read to get the latest news and all the details on GSoC 2025 projects and application process #cBioPortal #newsletter #gsoc2025 www.linkedin.com/pulse/welcom...

10.03.2025 19:41 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection Nature Reviews Cancer, Published online: 04 March 2025; doi:10.1038/s41568-025-00795-xIn this Review, Bruhm et al. provide a comprehensive overview of targeted and genome-wide cell-free DNA detection approaches, examining their potential to complement…
04.03.2025 11:22 πŸ‘ 12 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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Postdoctoral Fellow - Computational - Toronto (Region), Ontario (CA) job with Princess Margaret Cancer Centre | 12836915 We a seeking applications for a computational postdoctoral fellow with expertise in cancer epigenomics, chromatin biology, and data-driven research.

πŸ‡¨πŸ‡¦ Fast-track your computational biology/bioinformatics career in cancer research! πŸ‡¨πŸ‡¦

The Lupien Lab is looking to recruit a Postdoctoral Fellow in computational biology/bioinformatics ready for a challenge.

Apply now: www.nature.com/naturecareer...

12.02.2025 19:23 πŸ‘ 21 πŸ” 17 πŸ’¬ 1 πŸ“Œ 1
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Epigenomic heterogeneity as a source of tumour evolution - Nature Reviews Cancer Single-cell epigenomic technologies are refining our understanding of cancer evolution.

#REVIEW

Vallot, Lupien and Lasine describe how epigenomic heterogeneity generates dynamic reservoirs of tumour cell states, which can be leveraged in the design of novel therapies.
πŸ“– πŸ‘‰ https://bit.ly/40PCQ...

27.01.2025 15:13 πŸ‘ 14 πŸ” 8 πŸ’¬ 0 πŸ“Œ 1
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Ultra-processed food? Forever chemicals? Declining birth rates? What’s behind rising cancer in the under-50s? Research into the disease has never been more far-reaching, but there is little consensus as to what is causing the rocketing rates of diagnosis in young adults

Rates of #cancer in #young #adults have risen dramatically in recent years - as discussed in this article..

We urgently need to invest in #research πŸ§ͺ on early-onset cancers to understand - why?

www.theguardian.com/science/2025...

26.01.2025 13:53 πŸ‘ 112 πŸ” 41 πŸ’¬ 4 πŸ“Œ 2
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Program Head - Molecular Medicine, The Hospital for Sick Children Research Institute - Toronto (City), Ontario (CA) job with The Hospital for Sick Children (SickKids) Research Institute | 667223 Provide leadership and mentorship to members of the Molecular Medicine Program and influence the scientific direction of the Research Institute

Come be my boss!
We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children.
Toronto, Canada
(the deadline has been extended from Jan 31)
Please Re-post.
jobs.sciencecareers.org/job/667223/p...

24.01.2025 23:02 πŸ‘ 29 πŸ” 35 πŸ’¬ 1 πŸ“Œ 2

Indeed, there are a number of open positions for early career investigators in Toronto. It's a great city in a great country to pursue impactful science.

23.01.2025 15:55 πŸ‘ 11 πŸ” 7 πŸ’¬ 1 πŸ“Œ 0

Seems like a perfect day to consider continuing your research career in beautiful Canada! Recruiting an ECR in cancer research, a week left to apply.

23.01.2025 14:18 πŸ‘ 13 πŸ” 8 πŸ’¬ 1 πŸ“Œ 1

Absolutely thrilled to see the next next-generation sequencer arrive on our doorstep. Looking forward to affordable deep dives into cell-free genomes. Will we be able to reconstruct cancer genomes from blood without a biopsy, even for early cancers? We think so!

16.01.2025 14:53 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0