Diana Rubio-Contreras

H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death

Muy contentos de que nuestro último trabajo haya sido elegido como artículo del mes de febrero por la @sebbm.bsky.social @ibis-investigacion.bsky.social

🟠 SCIENCE |

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H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death Cell Death & Disease - H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death

New manuscript from the lab on @cddpress " H263A and SCAN1/H493R mutant TDP1 block TOP1-induced Double-Strand Break Repair during gene transcription in quiescent cells and promote cell death". rdcu.be/eSxtG @ibis-investigacion.bsky.social @unisevilla.bsky.social

Excited to see our research published!! 🎉

Amazing project in @fgh-lab.bsky.social at @ibis-investigacion.bsky.social

"H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death"

www.nature.com/articles/s41...

We are excited to welcome Evi Soutoglou and @rubenvanboxtel.bsky.social as our guest speakers at the upcoming GIIN webinar on Tuesday, November 4th at 5 PM Rome / 11 AM NYC.
Join us on zoom: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...

A comprehensive genetic catalog of human double-strand break repair The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...

Kickstarting our Bluesky🦋 account with great news!
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...

DNA2 enables growth by restricting recombination-restarted replication - Nature DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism - Oncogene Oncogene - EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism

Our latest study is now online! A great collaboration between the @fgh-lab.bsky.social and @enriquedealava.bsky.social Labs, driven by the outstanding work of J. Olmedo-Pelayo at @ibis-investigacion.bsky.social Check it out!

PLAMseq enables the proteo-genomic characterization of chromatin-associated proteins and protein interactions in a single experimental workflow. Chromatin Immunoprecipitation (ChIP) and Co-Immunoprecipitation (CoIP) assays are the most common approaches to characterize the genomic localization and protein interactors, respectively, for a prote...

New preprint from the Lab at @cabimer.bsky.social. We present PLAMseq, using TurboID to do like ChIPseq and proximity proteomics in the same protocol with extra powers like mapping protein interactions in the genome.

www.biorxiv.org/content/10.1...

HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells HMCES binding to nascent DNA blocks replication and kills homologous recombination–deficient cancer cells.

Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs. Congrats to María José and coauthors

HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances www.science.org/doi/10.1126/...

Suponemos que la publicación en cuestión es esta:
www.nature.com/articles/s41...

¡Enhorabuena @diana-rubio.bsky.social por el premio!

Su investigación en el #IBiS se ha centrado en la estabilidad del genoma humano a nivel molecular y celular, abarcando desde la comprensión de la respuesta celular a ciertos tipos de quimioterapia hasta las bases moleculares de enfermedades neurodegenerativas

🔵 La vida con IBiS |

Nuestra enhorabuena a la Dra. Diana Rubio Contreras por ser la ganadora del Premio Nacional de Juventud 2024 en la modalidad de Ciencia y Tecnología y cuya candidatura fue presentada por @FISEVI_sevilla

(Abrimos 🧵) @csic.es @unisevilla.bsky.social

The Genome Damage and Stability Centre at the University of Sussex has now joined BlueSky! Follow us here, for news, views and publications.

Osmotic disruption of chromatin induces Topoisomerase 2 activity at sites of transcriptional stress - Nature Communications Transcription creates superhelical stress in DNA, challenging genome stability. Here the authors find Top2 activity is uncorrelated with transcription unless chromatin is disrupted suggesting that chr...

Delighted to share the ground-breaking work from BBSRC Discovery Fellow @whgittens.bsky.social mapping physiological Top2 activity without poisons. Acute sensitivity enables sub-minute visualisation of Top2 hotspots hidden within sites of latent topological stress: www.nature.com/articles/s41...