Help! Viva in the UK on 17th. Currently in Australia. Etihad flight via Abu Dhabi on 10th likely to be cancelled. All Singapore/Cathay/Vietnam/China flights full or extortionate.
Any advice? Hold out or cop it and fly via US?
Almost there... It's a bad day to be a supplementary table. 360 pages 😮💨 #PhAlmostDone
@hakha.bsky.social and I wrote a Research Briefing (with a lay summary + "behind the scenes") of our paper on how genes are prioritized by GWAS and rare variant burden tests. 🧬🧪
www.nature.com/articles/d41...
Brilliant paper by Visscher et al.
Populations differ in traits/disease burden. Are these differences due to genetics?
Comparing single variants or polygenic scores between populations is biased due to environmental confounders correlated with the variants.
1/3
www.medrxiv.org/content/10.1...
A few thoughts on Herasight, the new embryo selection company. First, their whitepaper (drive.google.com/file/d/1EpFi...) implies that competitors like Nucleus have been marketing and selling grossly erroneous risk estimates. This is shocking if true! 🧵
What's going on in psychiatric genetics? The @pgcgenetics.bsky.social have now published our latest progress review in @thelancetpsych.bsky.social, highlighting discovery, and laying out a map for moving forwards!
www.thelancet.com/journals/lan...
You don’t need more ideas.
You need a better question.
A thread on clarity, chaos, & what a Nobel Prize winner, a mosquito net & a PhD meltdown taught me about writing (+ thinking) better.
🪨 Here’s my new Respect the Marble post: catherineeunicedevries.substack.com/p/you-dont-n...
🧵
We hope it can be used in other conditions to identify the best timing for intervention.🧠
Thanks to co-authors, participants of the #ALSPAC #CO90s #ABCDStudy and #MCS, and to funders @ukri.org MRC and @wellcometrust.bsky.social 🌟
This is the first application of network temperature 🌡️ in mental health and provides a network-wide alternative to node-focussed measures (centrality estimates) which lack applicability in mental health conditions...
Our findings highlight the criticality of early intervention in young people when symptoms are more flexible and responsive to intervention or treatment 🩺
Depression is not just about the type of treatment - but the timing! ⏳...
In 3 large longitudinal adolescent cohorts (@CO90s, @theabcdstudy MCS @CLScohorts) we found that temperature decreased across adolescence, meaning symptoms became more aligned and stable with age 📉🧊 ...
We applied this to depression symptoms:
In a high temperature network, symptoms are less stable and fluctuate 🔥
In a low temperature network, symptoms are stable and harder to shift 🧊 ...
Think of the transition from solid>liquid>gas: As temperature increases, particles become more random and less stable 🥵. As temperature decreases, the system becomes more rigid and fixed 🥶...
Depression is dynamic - symptoms interact over time. We can model depression using networks which capture symptom-symptom relationships. 🕸️
We applied a concept from statistical thermodynamics - temperature 🌡️ ...
Excited to share that the second paper from my PhD has just been published in @NatMentHealth!🧠🧵
We modelled depression symptom networks in >35k teenagers to derive their 'network temperature' and found evidence symptom stabilisation across adolescence...
www.nature.com/articles/s44...
Dissertation by Dr Rachel Los not only includes acknowledgements, but also .. anti-acknowledgements.
delta.tudelft.nl/en/article/a...
You've heard of DNA, but what about GNA? Very excited about this preprint with @jgthorp.bsky.social and others that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics as input. 1/2
www.medrxiv.org/content/10.1...
New large study (n ~ 6 million) in @JAMApsych tracking mental disorder trends in Denmark showing increases in mood disorders in recent birth cohorts tinyurl.com/c5nyfd8k
A fantastic week at #WCPG2024 in Singapore! Grateful to work and travel with many wonderful people 🔬🦀🇸🇬
The terrific @pgcgenetics.bsky.social Major Depressive Disorder Working Group in Singapore
Hello from Singapore #wcpg2024!🌏 I am presenting an update on the current results of the *Adolescent-Onset Depression GWAS* on Friday at 3pm in the symposium on Genomics and Life Course Data. Come and watch!
I’m presenting three different projects at these upcoming conferences over the next month! Looking forward to meeting fellow MH researchers 🌏
· World Congress of Psychiatric Genetics 🇸🇬
· International Congress of Neuropsychiatry 🇦🇺
· Society for Mental Health Research Conference 🇦🇺
🚨🌡️New pre-print on PsyArXiv!
We conceptualise and investigate *network temperature* as a measure of longitudinal stability in depression symptom networks across adolescence.
[Replication in 3 cohorts with >35k adolescents!]
osf.io/preprints/ps...
Network Temperature as a Metric of Stability in Depression Symptoms Across Adolescence: http://osf.io/9zmge/
This is the recording of my June 2024 keynote at the DPK congress, entitled "Embracing complexity: studying mental health problems as systems, not syndromes".
They made a nice recording & allowed me to share it.
Thanks a ton, DPK organizers 🖤.
🧪 #stats #psychscisky
www.youtube.com/watch?v=B1cR...
Great - thank you sm! I have performed MI and taken the mode of the variable combinations as final dataset >> Ising. Hopefully arguable given nature of the data/model? Then will run sensitivity with complete cases, with and without max likelihood estimator. Will look at IRT approaches too 👍
@eikofried.bsky.social any advice? 🙏😄
Missing data, longitudinal binary symptoms for multi-group Ising model estimation. HELP!!!! Impute? If so, how to pool estimates? Don't think it's right to avg. over networks? Use maximum likelihood estimator instead? 😵💫
We are also incredibly grateful to the participants and staff of the #ALSPAC and #ABCDstudy, to the PGC, 23andMe, the funders MRC and the reviewers! 🙏
