Jim Zoladek

Merci beaucoup à la @sfvirologie.bsky.social pour ce prix et pour ces journées riches en belle science ❤️🦠
Vivement l'année prochaine à Toulouse

En direct des #JFV2025!
@sfvirologie.bsky.social

The genetic driver of Acute Necrotizing Encephalopathy, RANBP2, regulates the inflammatory response to Influenza A virus infection Influenza virus infections can cause severe complications such as Acute Necrotizing Encephalopathy (ANE), which is characterised by rapid onset pathological inflammation following febrile infection. H...

Our latest collaborative study with the Pasteur Institute and University of Toronto on the role of RANBP2 in #influenza -associated hyperinflammation #AcuteNecrotizingEncephalopathy @aneinternational.bsky.social @ribonucleicacids.bsky.social @irim-life.bsky.social
www.biorxiv.org/content/10.1...

Congratulations! Such a nice study. What a year for the team 🎉

Thank you, Juan! I'm glad you enjoyed the read. I believe this small protein still has many secrets to reveal

Thanks for everyone involved in this study, and especially my great superviser who allowed all of this to happen @sebnisole.bsky.social ! 🎊

@irim-life.bsky.social

𝗪𝗵𝗲𝗿𝗲 𝗶𝘀 𝗠𝗜𝗧𝗗𝟭 𝗶𝗻𝗱𝘂𝗰𝗲𝗱 𝗯𝘆 𝗶𝗻𝘁𝗲𝗿𝗳𝗲𝗿𝗼𝗻?

🧠 Mouse data pointed to the 𝗯𝗿𝗮𝗶𝗻, so we tested human brain cells. Only microglia, the immune sentinels of the brain, showed interferon-driven MITD1 expression.

🚨 This makes 𝗠𝗜𝗧𝗗𝟭 𝗮 𝗺𝗶𝗰𝗿𝗼𝗴𝗹𝗶𝗮-𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰 𝗜𝗦𝗚, protecting the brain from flaviviruses

𝗛𝗼𝘄 𝗱𝗼𝗲𝘀 𝗠𝗜𝗧𝗗𝟭 𝗯𝗹𝗼𝗰𝗸 𝘃𝗶𝗿𝗮𝗹 𝗿𝗲𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻?

🧬 MITD1 overexpression forms cytoplasmic aggregates that deplete CHMP1B+4B, key ESCRT-III proteins.

🔬 PLA confirmed their recruitment to flavivirus replication factories. Knockdown of CHMP1B+4B hinders MITD1’s antiviral effect—proving a link

To uncover new host factors restricting flavivirus replication, we screened a library of >1,000 interferon-stimulated genes (ISGs) across multiple species.

Among known antiviral ISGs, we found 𝗠𝗜𝗧𝗗𝟭, a never-described-as-antiviral-before factor, as a potent inhibitor of WNV, USUV, ZIKV & DENV

MITD1 is a brain-specific interferon-inducible factor that inhibits flavivirus replication | PNAS West Nile virus (WNV) and Usutu virus (USUV) are closely related mosquito-borne neurotropic flaviviruses that share common transmission cycle and c...

🚨 New study in @pnas.org ! 🚨

We identified MITD1, a brain-specific interferon-inducible factor that 𝗶𝗻𝗵𝗶𝗯𝗶𝘁𝘀 𝗳𝗹𝗮𝘃𝗶𝘃𝗶𝗿𝘂𝘀 𝗿𝗲𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻, including WNV, USUV, ZIKV & DENV.

🔗 Read the paper: www.pnas.org/doi/10.1073/...
👇 Thread with take-home messages below!

#Virology #Flavivirus #Interferon

Check our latest opinion piece, just out in @cp-trendsmicrobiol.bsky.social! We delve into how the antiviral RNase ISG20 targets viral RNA and how some viruses escape it.
@irim-life.bsky.social @ciri-lyon.bsky.social

www.cell.com/trends/micro...