Stacie Dodgson, PhD

Good news keeps coming! Excited to share our latest preprint expanding myeloid cell editing capabilities: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by Hyuncheol Jung and Pascal Devant joint with @juliacarnevale.bsky.social

Causal modelling of gene effects from regulators to programs to traits - Nature Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.

GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult.

Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:

Executive wants to frame the NIH indirects cut as $4B in savings.

But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.

A very simple script. Feel free to adjust for your needs.

"I JUST READ THAT MUSK AND TRUMP ARE CUTTING BILLIONS OF DOLLARS IN CANCER AND ALZHEIMER RESEARCH MONEY. I DIDN'T VOTE FOR CANCER. ARE YOU SUPPORTING THIS? WHAT ARE YOU DOING TO STOP THEM?"

reps.fyi

This is a list of blockbuster drugs in 2024. Guess how many can trace their origins to NIH funded research?
All of them.

Vaccines have saved + continue to save millions of lives from infectious diseases. It is normal to have questions about how they work & what makes a successful vaccine. In that spirit here are 3 excellent articles from people worth listening to - pls share:

Vaccine Information Statements (VISs) Overview | Immunize.org| Immunize.org Find materials on legal requirements to give VISs to patients before vaccinating.

Vaccines and immunization fact sheets you can't find on CDC website anymore are archived at the link below. May be helpful to bookmark this for future reference.
www.immunize.org/vaccines/vis...

Karin Pelka is co-organizing a Single Cell Biology To Tissue Ecosystems @keystonesymposia.bsky.social conference, May 11-14 in Whistler, abstract deadline February 11. It’s immunology-heavy, but covers a few disease areas and will be joint with the Organoid Engineering Keystone. Take a look 👇

Headshots of 102 women and non-binary scientists who are now assistant professors. At the bottom is the Leading Edge logo and www.leadingedgesymposium.org

Leading Edge is celebrating a milestone: 100 (actually 102!) new assistant professors!!! 🎉🥳🎊

Learn more about them:
www.leadingedgesymposium.org/fellows/

Applications are now open for the 2025 Leading Edge cohort! (Deadline Feb 3).

You do NOT need to be ready for the job market to apply.

Associate or Full Professor Rank Search to join the Arc Institute as a Core Investigator and the Stanford Department of Bioengineering | Arc Institute Arc Institute is a independent nonprofit research organization headquartered in Palo Alto, California.

Seeking pioneering scientists in immunology, neuroscience, and machine learning! Join Arc Institute as a Core Investigator + Stanford Bioengineering as Associate/Full Professor. Full lab funding and cutting-edge facilities in Palo Alto. Apply by Jan 15 for full consideration: shorturl.at/CuH1K

Naturally occurring T cell mutations enhance engineered T cell therapies - Nature A study examines the effects of mutations that occur naturally in T cell cancers, reporting that such mutations can potentially be exploited to increase the potency of T cell therapies.

For me it is "Naturally occurring T cell mutations enhance engineered T cell therapies"

The idea is so simple: use naturally occurring somatic mutations as an in vivo screen. Evolution finds mutations that improve T-cell persistence and survival which would not have been discovered with CRISPR.