Alles Lab

Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis - Nature Neuroscience Su et al. show that inflammatory arthritis pain stems from sustained interferon-driven MNK1/MNK2–elF4E signaling that sensitizes joint-innervating neurons. Blocking this pathway reverses pain, suggest...

BOOM! Fantastic new paper from Patrik Ernfors and his team: www.nature.com/articles/s41... Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis

Gabapentin has been an effective medication for many people living with pain. It is particularly helpful for neuropathic pain when used thoughtfully.

Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms Sensory neurons of the dorsal root ganglia (DRG) and trigeminal ganglia (TG) are critical for transmitting somatosensory information, including pain, to the central nervous system. In these neurons, a...

First pub of 2026! Enjoy www.jneurosci.org/content/46/3...

Saved me the flight! Thanks, dude 😎

A Podcast by Neuroverse: Tools for Looking into the Brain -… Explore what pain really is and why it’s so complex. In this podcast, Prof. Sascha Alles unpacks how chronic pain develops and how the brain processes it.

Chatting about #painresearch in this recent podcast. Listen here www.scientifica.uk.com/podcasts/a-p...

Potential role for immune cell signatures as predictors of acute and chronic pain in adolescents post major musculoskeletal surgery - PubMed Our findings suggest that immune cell signatures are potentially useful as biomarkers, prognostic indicators, and guides for personalized surgical recovery in youth.

Very nice recent study from the Chidambaran Lab in our dept @cincychildrens.bsky.social suggesting potential immune cell signatures in acute vs chronic post-surgical pain #PainResearch pubmed.ncbi.nlm.nih.gov/41077098/

Physiological actions of a humanized P2X4 scFv on peripheral and central neurons in male mice with neuropathic pain Neuropathic pain remains a challenging clinical condition due to its resistance to conventional analgesics. The purinergic P2X4 receptor (P2X4R), an A…

Our final contribution to this collaboration is now online. We obtained electrophysiological recordings of DRG/TG neurons and Fos+ neurons of spinal dorsal horn & vlPAG in 2 models of neuropathic pain to study the actions of a humanized P2X4R scFv #PainResearch www.sciencedirect.com/science/arti...

Back in the saddle! #PainResearch #ephys

⚡We are finally electrocuting DRG neurons in the @alleslab.bsky.social since moving to @cincychildrens.bsky.social! #PainResearch #ephys #NeuroSkyence

First grant since joining @cincychildrens.bsky.social has been awarded!! Excited to get to work on NIH HEAL Initiative "Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome" with the de la Pena lab!!! #PainResearch

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One of our final papers from this collaborative effort involving collaborators at UNM, Mayo Clinic, & McGill. Here we validate a humanized scFv targeting hP2XR. Kudos to first-author @docnessmonster.bsky.social & former lab member Mark S. for making this happen! journals.sagepub.com/doi/10.1177/...

A combined activity of peripheral nociceptive and... : PAIN eptors. Using electrical and optogenetic approaches, we selectively activated different fiber subtypes without causing neuronal injury. Our findings demonstrate that only simultaneous activation of bo...

Elegant work highlighting an important aspect of PA activity in sciatic nerve injury-related chronic pain! journals.lww.com/pain/fulltex... #PainResearch

SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

Transporters in pain! Exciting work from @middletonsj.bsky.social & Bennett lab @ox.ac.uk www.nature.com/articles/s41... #PainResearch

Three lab members standing proudly in front of a newly assembled electrophysiology rig. The setup includes a micromanipulator, amplifier, and monitor, with cables neatly arranged. Everyone is smiling in casual lab attire, celebrating the milestone in a well-lit lab space.

📸 Big day in the lab!
Our new electrophysiology rig is officially up and running — huge thanks to everyone who helped make this happen. Excited for the science ahead! 🧠⚡️
@alleslab.bsky.social @cincychildrens.bsky.social #PainResearch

Almost ready to rumble! #ephys #PainResearch @cincychildrens.bsky.social

Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats - Nature Communications Lung and thymoma cancer patients often suffer from autoimmunity and related painful neuropathies. Here the authors show that patient-derived anti-CRMP5 autoantibody binds to rat dorsal root ganglia to...

I’m proud to share that our first paper from the lab has just been published in Nature Communications: www.nature.com/articles/s41...
This work uncovers a mechanism by which autoantibodies targeting CRMP5 contribute to neuropathic pain in paraneoplastic syndromes.
#PainResearch

Thanks for the highlight of our recent work! #PainResearch @painresforum.bsky.social
painresearchforum.org/paper/expres...

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Our collaborative study with the de la Peña lab is now online! Here we analyzed ephys & transcriptomic actions of gabapentin on hDRG neurons. Kudos to co-first authors Jenna & @docnessmonster.bsky.social. Special thks to our donors & their families #PainResearch journals.sagepub.com/doi/10.1177/...

This is really concerning.

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Now online - our studies of mouse and human sensory neurons in the context of visceral pain! #PainResearch journals.sagepub.com/doi/10.1177/...

Spatial organization, chromatin accessibility and gene-regulatory programs defining mouse sensory neurons - Communications Biology Single cell RNA-sequencing, spatial transcriptomics and chromatin analyses of sensory neurons provide insights into cell type organization of the dorsal root ganglion and the enhancer-driven co-regula...

A read only for the DRG nerd: "Spatial organization, chromatin accessibility and gene-regulatory programs defining mouse sensory neurons". www.nature.com/articles/s42...

A robust expression system reveals distinct gating mechanisms and calmodulin regulation of NaV1.9 channels An expression system enables detailed study of NaV1.9 channel gating and its regulation by calmodulin.

Great week for Nav channel work - this time it's Nav1.9 from the Bosmans lab www.science.org/doi/10.1126/...

Modulation of human dorsal root ganglion neuron firing by the Nav1.8 inhibitor suzetrigine - PubMed Nav1.8 voltage-gated sodium channels are strongly expressed in human primary pain-sensing neurons (nociceptors) and a selective Nav1.8 inhibitor VX-548 (suzetrigine) has shown efficacy for treating ac...

Modulation of human dorsal root ganglion neuron firing by the Nav1.8 inhibitor suzetrigine pubmed.ncbi.nlm.nih.gov/40424150/ #PainResearch

Lab outing for a Reds game and we beat the Cubs... go @reds.com!

Good times at the Cincy Neuroscience Retreat connecting with neuro people @cincychildrens.bsky.social & UC and exploring trails of Ohio! #neuroskyence

Trpv1-dependent Cacna1b gene inactivation reveals cell-specific functions of CaV2.2 channels in vivo Voltage-gated CaV2.2 channels underlie the N-type current, and they regulate calcium entry at many presynaptic nerve endings to control transmitter release. A role for CaV2.2 channels has been well-es...

Lovely preprint with some thought-provoking findings from Diane Lipscombe's group www.biorxiv.org/content/10.1...

Alles lab

First day! @cincychildrens.bsky.social #PainResearch

Human assembloid model of the ascending neural sensory pathway - Nature A human ascending somatosensory assembloid model was developed, which integrates multiple organoids to simulate the spinothalamic pathway, demonstrating functional connectivity and responsiveness to s...

www.nature.com/articles/s41...

🔬 Exciting discovery! We've been curious about the function of unique IBA1+ cell staining we observed around healthy human DRG neurons in the lab (indicated by red arrows). A new paper @cellpress.bsky.social finally provides some answers. Link: www.cell.com/cell/fulltex...

Woah 🤯