Padmanee (Pam) Sharma, MD, PhD

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

What a pleasure and honor to have the Nobel Prize @jimallisonphd.bsky.social and the brilliant @pamsharmamdphd.bsky.social at Regina Elena National Cancer Institute in Rome, for the Raffaele Tecce memorial lecture. Immuno past and future! #savelife

Submit your abstract by Dec. 19 (11:59pm MST) to secure a poster presentation spot at our Precision Oncology meeting. Connect with experts such as @pamsharmamdphd.bsky.social in precision medicine, cancer treatment, and health equity! hubs.ly/Q02_9vH10 #KSPrecisionOnc25
@mdanderson.bsky.social

Method of the Year 2024: spatial proteomics - Nature Methods Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

Spatial Proteomics named ‘Method of the year’ by @naturemethods.bsky.social .

Very exciting technology 🔬 #science #research #omics

www.nature.com/articles/s41...

Jim Allison, amazing leader and inspiration!

Let’s see… David Baker and Victor Ambros! And Jim 🤓🧐

De novo protein synthesis for specific recognition of peptide-MHC complex! This represents the potential for significant advancement in the development of immunotherapies!

doi: doi.org/10.1101/2024...

How many Nobel Laureates can you name? It was an absolute pleasure to spend time with friends, including Sid Mukherjee & Doug Hanahan & Sabeena Merchant, and to hear stories of science, dedication & teamwork that led to the Nobel Prize for these brilliant, compassionate, fun & badass individuals!

Nobel Prize Lecture in Chemistry with incredible promise for the future to use AlphaFold & development of new proteins to improve treatments for diseases and provide sustainability for our planet! Congratulations to David Baker, John Jumper & Demis Hassabis @demishassabis.bsky.social

Working on my end-of-year analysis for public health and came across this shocking statistic:

The percent of Ameircans vaccinated for the flu has dropped from 67% in 2019 (pre-COVID) to 38% today.

Influenza has been a leading cause of death in America almost every year since at least 1980.

This show took the concept of work-life balance to a whole other level & left me unsure of how to answer questions from students & junior faculty about how they can achieve work-life balance in academic medicine… looking forward to season 2 for some answers!

#SEVERANCE

1
17
25

youtu.be/_UXKlYvLGJY

Nobel prize week, a yearly celebration of science.
Great to catch up with @jimallisonphd.bsky.social & @pamsharmamdphd.bsky.social back again in Stockholm.

Brilliant lectures today by Victor Ambros & Gary Ruvkun for 2024 Nobel Prize in Medicine! I learned a lot about the Worm Breeders Gazette 🪱

🚨2024 VinFuture Special Prize for Innovators with Outstanding Achievements has been awarded to Professors Zelig Eshhar (Israel), Carl H. June, and Michel Sadelain (United States) @PennMedicine @vinfutureprize www.accesswire.com/951373/the-2...

Back in Stockholm to celebrate Nobel Week with @jimallisonphd.bsky.social
Always so much fun!! 🤩❤️🥰💕

First Ever Image of a Multi-Planet System around a Sun-like Star Captured by ESO Telescope The European Southern Observatory’s Very Large Telescope (ESO’s VLT) has taken the first ever image of a young, Sun-like star accompanied by two giant exoplanets. Images of systems with multiple exopl...

#Science 🔭 is awesome
First Ever Image of a Multi-Planet System around a Sun-like Star Captured by ESO Telescope
www.eso.org/public/news/...

Single cell transcriptomics reveal mast cell heterogeneity in the human gut Gut mast cells are key players in infection and inflammation, as well as in homeostasis. Mast cells regulate gastrointestinal (GI) function by controlling vascular and epithelial permeability, and int...

Intro time! I'm Hind, a mucosal #immunologist working in KU Leuven on mast cells in health and in gut disease.
Speaking of, I can finally show what I have been working on for the last 4 years, ie characterizing human mast cells in layers of the colon via scRNAseq
www.biorxiv.org/content/10.1...

Noor (@noorpratap.bsky.social) has been working on this for quite some time! It took a bit of work to figure out, but now you can map your scATAC-seq reads directly to the genome and sort and dedup them with alevin-fry-atac. You get a BED file with counts ready for downstream analysis! 1/

Our new tradition every Thanksgiving. watching Jim Allison: Breakthrough movie. Must-watch, especially students interested in science and medicine. Modern day #superman (cape missing) who saves millions of lives. Inspirational
@jimallisonphd.bsky.social @pamsharmamdphd.bsky.social
amzn.to/4gdxXaR

Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪

go.bsky.app/PY5tCas

go.bsky.app/FmERUoD

go.bsky.app/6aT6qDS

go.bsky.app/QSEPDoj

A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function Organ function requires coordinated activities of thousands of genes in distinct, spatially organized cell types. Understanding the basis of emergent tissue function requires approaches to dissect the...

Sometimes I read a pre-print that moves the needle, typically on bioRxiv where all the good new stuff first appears. Two first class tech-dev pioneers and their fearless postdocs collaborate creating tour de-force methods -->
www.biorxiv.org/content/10.1...

Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer | NEJM Patients with microsatellite-instability–high (MSI-H) or mismatch-repair–deficient (dMMR) metastatic colorectal cancer have poor outcomes with standard chemotherapy with or without targeted therapi...

Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer
www.nejm.org/doi/full/10....

Great work! Congrats!

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

Tissue-resident B cells orchestrate macrophage polarisation and function - Nature Communications The function of B cells in peripheral blood and secondary lymphoid organs has long been appreciated but whether and how they contribute to tissue immune homeostasis is lesser known. Non-lymphoid organ...

Briefly re-reading this paper in preparation for giving my talk this morning at EMDS2024. Such a lovely paper. www.nature.com/articles/s41...

Recovery of biological signals lost in single-cell batch integration with CellANOVA - Nature Biotechnology A statistical framework quantifies single-cell batch variation and recovers meaningful biological signals.

A new method to recover biological signal lost after data integration.

GitHub:
github.com/Janezjz/cell...

Nature Biotech Paper: www.nature.com/articles/s41...

The immune system for the win against cancer 🙌

HPV vaccine stops 90% of cervical cancer cases - BBC News England began vaccinating teenage girls in 2008 and results show it is paying off.

HPV vaccine stops 90% of cervical cancer cases in England 🏴󠁧󠁢󠁥󠁮󠁧󠁿

www.bbc.com/news/article...

Welcomed Dr. Charles Blanke to Rhode Island Hospital/Brown University for grand rounds. What a career he has made- GI oncologist ➡️ SWOG Group Chair ➕️ tireless advocate for compassionate care - and autonomy- at the end of life. Proud to call him friend. #oncsky h/t @weldeiry.bsky.social