Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
Happy to share our new study that was just published in Neuron! www.cell.com/neuron/fullt...
Friends, I’m excited to release OpenSpliceAI, an open‐source, efficient, and modular framework for splice site prediction. It reimplements and extends SpliceAI (Jaganathan et al., 2019) using the modern PyTorch framework. 1/
Mihaela Pertea, @stevensalzberg.bsky.social, Anqi Liu, Alan Mao
Bluetorial:
The announcement to move scientific review out of the institutes and centers into the Center for Scientific Review (CSR) and its potential consequences
Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in @naturegenet.bsky.social with @trajnp.bsky.social and @panosroussos.bsky.social @sinaibrain.bsky.social www.nature.com/articles/s41...
Roche's SBX sequencing by expansion - preprint out!
www.biorxiv.org/content/10.1...
New essay on NIH and indirect costs:
goodscience.substack.com/p/indirect-c...
On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...
A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it.
www.science.org/content/blog...
Insanely good news if this holds up.
Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor
www.science.org/doi/10.1126/...
SOME GOOD NEWS ABOUT NIH FUNDING
Closed sessions of institute and center Advisory Counsel meetings are now permitted. This is where grant applications are discussed and approved for potential funding.
Open sessions where there are public presentations and discussions are still not allowed.
Just coincidentally found GenBank Release 84.0 from 1994 in the neighboring lab. Anyone out there with an even older version?
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1/5
So, how did DeepSeek develop DeepSeek R1?
They used both DeepSeek-V3-Base and a simple prompt:
1. They asked the same question multiple times to DeepSeek-V3-Base as a group.
2. They then graded the answers, assigning an accuracy score and a format score (e.g., <think></think>).
Researchers at tech giant Meta have created a machine-learning system that almost instantaneously translates speech in 101 languages into words spoken by a voice synthesizer in any of 36 target languages.
https://go.nature.com/3WiibUA
www.prnewswire.com/news-release...
UK Biobank to run 5.4K protein Olink assay on 600K samples using Ultima UG100
#Splicing #Huntingtons #Disease #TDP43 #m6A
www.nature.com/articles/s41...
A new large language of life model (LLLM) for the transcriptome that predicts gene expression within and across human cell types www.nature.com/articles/s41... @nature.com
For more on the remarkable surge of LLLMs see erictopol.substack.com/p/learning-t...
So here's an interesting development...
It's been observed that shingles vaccination with the live attenuated vaccine Zostavax:
www.medrxiv.org/content/10.1...
and also with the (much more effective) recombinant vaccine:
www.nature.com/articles/s41...
But, though the study designs are strong...
A timeline titled "Antibiotics: time from discovery to introduction" shows when each antibiotic drug class was first discovered versus first available for medical use. Data: Hutchings, Truman, Wilkinson (2019). Created by Saloni Dattani for Our World in Data.
You may have heard that it took a long time for penicillin to be scaled up.
What about other antibiotics? How long did it take for them to be mass produced and introduced clinically, after they were discovered?
I created a visualization of this here:
Google research scholar programme applications open until 27th Jan. support early-career professors (received PhD within seven years of submission).
research.google/programs-and...
Delighted to highlight our new paper in
@natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...
@markhisted.org lays down some knowledge.
What are recurrent networks doing in the brain?
www.thetransmitter.org/neural-netwo...
#neuroscience
Last update of our databases for the year.
Download them here:
493 early-career funding opportunities: research.jhu.edu/rdt/funding-...
313 postdoc fellowships: research.jhu.edu/rdt/funding-...
189 PhD fellowships: research.jhu.edu/rdt/funding-...
how do you all remember every UUID? I find it really hard. so I wrote them all down on every uuid dot com
the list has fast search across all 2^122 values (so you can find your favorites) - hoping to add some social features like "trending UUIDs" soon!
Amazing new work from the lab of @aliceyting.bsky.social @stanfordmedicine.bsky.social @stanfordbiosci.bsky.social, engineered GPCRs for ligand-activated cell responses
www.nature.com/articles/s41...
Crosslinks can sometimes improve AlphaFold3 models. Crosslinking is an experimental method often used as a source of distance restraints in modeling. In AlphaFold3, instead of using restraints, crosslinks can be included as covalent ligands. Thanks to Agnieszka Obarska-Kosinska for the idea.
