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Hellerschmied Lab

@hellerschmiedlab

Biochemistry and cell biology lab @unidue-zmb.bsky.social Excited about secretory pathway and #Golgi #proteostasis mechanisms funded by AvHStiftung, part of @crc1430.bsky.social (tweets by PI)

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28.12.2024
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Latest posts by Hellerschmied Lab @hellerschmiedlab

#JobOffer We’re recruiting a tenure-track group leader working on cell metabolism (broadly defined, including lipid metabolism, organelle bioenergetics, etc.). Happy to chat informally about the department: great science, great people, and strong collaboration opportunities! Reposts appreciated πŸ™

11.03.2026 12:59 πŸ‘ 9 πŸ” 8 πŸ’¬ 0 πŸ“Œ 1
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Are you headed to #GRC #Autophagy in Stress, Development and Disease next week, and interested in speaking with a JCB editor about publishing? Get in touch with our Executive Editor Tim Spencer, who will be there!
βœ‰οΈ Email Tim:
rupress.org/jcb/pages/ed...

11.03.2026 14:15 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Interested in Activity-based Protein Profiling?

We are excited to host the 15th Activity-based Protein Profiling meeting (@abpp2027.bsky.social #ABPP2027) on June 2nd to 4th, 2027, at Naturalis in Leiden.

Save the date and sign up for our mailing list: www.universiteitleiden.nl/en/science/l...

27.02.2026 12:53 πŸ‘ 13 πŸ” 7 πŸ’¬ 0 πŸ“Œ 0
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πŸ“’ Next Proteostasis Consortium Seminar – Wednesday 11 March 2026 at 4:00β€―pm GMT (10:00β€―am CT)

πŸ‘‰Link & Updates here: www.proteostasisconsortium.com/seminars/

Speaker: Prof. Ruth Scherz-Shouval (Weizmann Institute of Science)
Title: Stress responses in the tumor microenvironment

09.03.2026 13:02 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

The application deadline for the 20th FEBS/EMBO Spetses meeting is extended to the 15th March! Please sign up at the link below, or encourage your PhDs and postdocs to come along for what is certain to be a wonderful week!

09.03.2026 13:08 πŸ‘ 7 πŸ” 7 πŸ’¬ 0 πŸ“Œ 0
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Registration for the 7th Summer School in Medical Physics 2026 is open!
πŸ“† 24.08. – 02.10.26
The course provides a comprehensive introduction to the role of 3D printing in medical physics, with a particular focus on applications in radiotherapy.
More Info πŸ‘‰ dkfz.de/summer_schoo...

09.03.2026 14:23 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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A strong Perutz presence in a new @fwf-at.bsky.social consortium: @elifkaragoz.bsky.social will coordinate the Emerging Fields project 'Translating the Ribosome Code of Pediatric Cancers' 🀝 The team includes @sebastianfalk.bsky.social and @marco.heinlab.org ➑️ tinyurl.com/3d6z3ry5

09.03.2026 10:05 πŸ‘ 27 πŸ” 3 πŸ’¬ 1 πŸ“Œ 2
Preview
M1-linked ubiquitination by LUBAC regulates AMPK signalling and the response to energetic stress - Cell Death & Differentiation Cell Death & Differentiation - M1-linked ubiquitination by LUBAC regulates AMPK signalling and the response to energetic stress

More evidence that LUBAC has functions beyond inflammation: Our study shows that LUBAC regulates AMPK signalling to control metabolic adaptation, autophagy, and cell death. This might explain the metabolic problems observed in LUBAC deficiency and ORAS patients. www.nature.com/articles/s41...

07.03.2026 18:13 πŸ‘ 12 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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Ubiquitin & Friends Fiesta in Vienna, 29-30 April 2026.
Great speakers, small size, a friendly community, perfect for early-career researchers to connect with fellow ubiquitin enthusiasts. Sign up at www.protein-degradation.org/symposium/ and submit abstracts for talks and awards.
#ubfriends26

06.03.2026 06:48 πŸ‘ 20 πŸ” 15 πŸ’¬ 1 πŸ“Œ 2
Preview
The accessory adapters FAF1, FAF2, and UBXN7 accelerate proteasomal degradation by increasing prior p97-mediated substrate unfolding A group of accessory adapters positions the p97 adapter Ufd1 to boost substrate unfolding and subsequent proteasomal degradation.

VCP/p97’s accessory adapters (FAF1, FAF2, UBXN7) boost unfolding and subsequent proteasomal degradation. #ubiquitin. Our paper is out now:
Science Advances www.science.org/doi/10.1126/...

06.03.2026 19:11 πŸ‘ 21 πŸ” 9 πŸ’¬ 0 πŸ“Œ 1

A Cinderella story: raising CLIP-tag from the ashes to shine in fluorescence labeling.
www.biorxiv.org/content/10.6...

08.03.2026 09:28 πŸ‘ 31 πŸ” 15 πŸ’¬ 0 πŸ“Œ 1
Image of FAF2's predicted helical domain interacting with the UFD1 UT3 domain. Next to this are similar images showing the predicted binding of de novo designed protein binders to the same region. Above is a sequence alignment indicating the key residues involved in the interaction.

Image of FAF2's predicted helical domain interacting with the UFD1 UT3 domain. Next to this are similar images showing the predicted binding of de novo designed protein binders to the same region. Above is a sequence alignment indicating the key residues involved in the interaction.

🚨⚠️ New Preprint Alert! ⚠️ 🚨
www.biorxiv.org/content/10.6...

Screening p97 cofactors, @prithadg.bsky.social identified FAF2 as the strongest activator of the p97-UFD1-NPL4 complex. Leveraging her mechanistic descoveries, we designed π˜₯𝘦 𝘯𝘰𝘷𝘰 binders that could also enhance p97 substrate unfolding.

01.03.2026 12:55 πŸ‘ 27 πŸ” 13 πŸ’¬ 2 πŸ“Œ 0

Check out the highlight! Great work by our lab neighbours @hemmo-lab.bsky.social @unidue-zmb.bsky.social @unidue.bsky.social

08.03.2026 08:15 πŸ‘ 5 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Congratulations!! #proudPI

07.03.2026 18:55 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Job Alert: The Institute of Integrative Cell Biology & Physiology
@uni-muenster.de is recruiting a lecturer starting 1 July 2026 - permanent, full-time position with 9 SWS teaching. Join a vibrant research and teaching environment in #MΓΌnster. Apply by April 15th: tinyurl.com/wn7kesdb

06.03.2026 15:07 πŸ‘ 5 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0
LinkedIn Login, Sign in | LinkedIn Login to LinkedIn to keep in touch with people you know, share ideas, and build your career.

πŸ§ͺ Chem(bio) friends, this one is big!!πŸ”₯
@irbbarcelona.org is opening a Group Leader position in Chemical Biology! πŸ’œ

If your research plan and vision are at the interface of synthetic chemistry, chemical biology, and biomedicine, please check the call!
πŸ‘‡
recruitment.irbbarcelona.org/jobs/7334978...

06.03.2026 15:53 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

Kicking off the last session of the symposium, our keynote speaker @mkoehn.bsky.social from
@unibonn.bsky.social spoke about peptide tools used to dissect phosphatase-substrate interactions. Have a look at the human dephosphorylation database (DEPOD) via the link www.depod.org

1/3

#17GPS

06.03.2026 13:16 πŸ‘ 3 πŸ” 3 πŸ’¬ 2 πŸ“Œ 0
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Thrilled to be hosting Brenda Schulman, @aakritijain.bsky.social, @crismayorruiz.bsky.social @davidbalchin.bsky.social, @hemmo-lab.bsky.social, Ian Ganley, @kirsteinlab.bsky.social, Juliette Fedry, @elliottlab.bsky.social & @plantophagy.bsky.social - BIG THANKS for accepting the invitation πŸ™

10.01.2026 00:47 πŸ‘ 7 πŸ” 4 πŸ’¬ 1 πŸ“Œ 0
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And just like that, Day 2 of the #Peptide Symposium is almost over! Only one more day left! With that, we already want to say thank you to all the speakers and attendees for making this a truly engaging symposium! Now let’s head to the conference dinner.

#17GPS

05.03.2026 17:15 πŸ‘ 5 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
The wonderful historic city of Marburg

The wonderful historic city of Marburg

🚨 University Marburg (Germany) is recruiting a W2 Professor of Mol. Pharmacology in the Faculty of Medicine.

Focus areas: Epithelial adaptation in #inflammation, #regeneration, and/or #cancer

stellenangebote.uni-marburg.de/jobposting/0...

#AcademicJobs #Pharmacology #FacultyPosition #cellbio

05.03.2026 11:39 πŸ‘ 20 πŸ” 18 πŸ’¬ 0 πŸ“Œ 0
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I am incredibly excited to share that I will start my independent lab at the @unidue-zmb.bsky.social at the @unidue.bsky.social as Junior Professor of Cellular Biochemistry. Research in my lab has the goal to decipher the ubiquitin code!
There are multiple open positions!
(1/3)

05.03.2026 11:00 πŸ‘ 83 πŸ” 22 πŸ’¬ 11 πŸ“Œ 4

Looking forward to your start in the department!!

05.03.2026 14:41 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

ZMB members, @mbogyo.bsky.social will be giving the ZMB/CRC1430 talk tomorrow at 11 am. Set a reminder and don’t miss out on this fantastic talk!

04.03.2026 17:58 πŸ‘ 1 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Contact/Job - Department of Molecular and Cellular Biology - UNIGE

You are finishing your PhD and looking to continue in science?

The Martin lab @biology-unige.bsky.social has an open postdoctoral position in cell biology to study cell-cell fusion. For more information, please consult mocel.unige.ch/research-gro....

Thanks for reposting!

03.03.2026 09:42 πŸ‘ 60 πŸ” 74 πŸ’¬ 1 πŸ“Œ 2
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The new Vienna BioCenter Interdisciplinary Postdoctoral Program (VIPΒ³) is here! We have 8 fully-funded positions for scientists with a PhD in biology, chemistry, physics, bioinformatics etc.

The call is open!

More information: training.vbc.ac.at/post-docs/vi...

#VBCPostDoc

02.03.2026 13:18 πŸ‘ 13 πŸ” 11 πŸ’¬ 0 πŸ“Œ 1
Prime Tagging

As we are sending back the revised version of our pooled prime editing gene tagging paper, I am happy to share a website for design of prime tagging libraries, including some images, all generated from a single pooled transduction and in situ sequencing.
primetagging.org

02.03.2026 13:40 πŸ‘ 6 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
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Fantastic news! πŸ™Œ The Perutz is excited to welcome Danny Nedialkova as a new group leader starting this April! πŸŽ‰ She will strengthen the institute's research on the fundamental mechanisms that shape cellular physiology and disease ➑️ www.maxperutzlabs.ac.at/research/res...

02.03.2026 14:27 πŸ‘ 61 πŸ” 12 πŸ’¬ 1 πŸ“Œ 4
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πŸ“†In just one week, we will be hosting the 17th German #Peptide Symposium in Essen @unidue.bsky.social!

We are excited to host an open-topic event on modern peptide chemistry with a fantastic line up of speakers.

#17GPS

1/3

25.02.2026 12:07 πŸ‘ 4 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0

πŸ‘‹I’m @lanabuzuk.bsky.social a PhD student from the @hellerschmiedlab.bsky.social , and I will be taking over the ZMB account for the duration of the symposium (4th – 6th March) and I will be providing live coverage of the talks and the events.

3/3

25.02.2026 12:09 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1
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It was fun writing this book chapter on methods to trace #lipid metabolism.

Congrats to Alec and Helene for their effort. Thanks to @jeremybaskin.bsky.social for the invitation to contribute this chapter. @ohsunews.bsky.social @ohsummi.bsky.social

www.sciencedirect.com/science/chap...

21.01.2026 14:59 πŸ‘ 7 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0