CU Department of Biomedical Informatics

a set of hexagonal logos (hexbin style display) displaying software tools. All logos are partially blurred and faded besides the CCC logo

Using a familiar correlational coefficient like Spearman’s or Pearson’s on molecular data may miss some complex patterns that exist.

To overcome this, researchers at @cuanschutz.bsky.social including @miltondp.bsky.social developed CCC—a new statistical framework ➡️ https://cudbmi.info/ccc-1

Large Language Models with Temporal Reasoning for Longitudinal Clinical Summarization and Prediction Maya Kruse, Shiyue Hu, Nicholas Derby, Yifu Wu, Samantha Stonbraker, Bingsheng Yao, Dakuo Wang, Elizabeth M. Goldberg, Yanjun Gao. Findings of the Association for Computational Linguistics: EMNLP 2025...

LLMs show promise for supporting clinicians, but there are still challenges with their implementation. Researchers @cuanschutz.bsky.social established a foundation for evaluating LLMs' abilities with multi-modal data and temporal reasoning.

graphic depicting data chart with oscillations reprinting sparse data prediction

Sparse data and lack of reliable models are challenges in estimating biological systems. Researchers at @cuanschutz.bsky.social introduced a multi‑objective data assimilation framework for complex biological systems➡️ https://cudbmi.info/multiobjective-optimization1

a lot of medication blister packs in a pile containing medications of different color, size, and shape suggesting comprehensive medication management (CMM)

Clinicians have a lot to consider for patient medications.

LLMs could support medication management, but medications pose unique challenges for these LLMs. @cuanschutz.bsky.social researchers developed a benchmark suite to evaluate these implementations: https://cudbmi.info/rx-llm-1

Inside Pharmacogenetics: How CU Anschutz Researchers Are Using Metabolism to Guide Safer, More Personalized Treatment Discover how genetics, metabolism, and advanced research at CU Anschutz are shaping safer, personalized medication decisions for every patient.

How your body breaks down medication is more unique than you think. Researchers at CU Anschutz’s Claw Lab are mapping the genetic and metabolic differences that shape drug responses, and building models that could help clinicians personalize dosing with greater equity and precision.

clinician looking at a monitor screen in hospital or icu setting with iv bag hanging

Researchers developed a model that leverages EHRs to predict which children with severe TBI will go on to receive ICP monitoring. The findings can inform the design of a clinical decision support tool. Learn more ➡️ https://cudbmi.info/icp_monitor_tbi1

PhD programs worldwide face an urgent question: How should trainees use ChatGPT, Claude & similar tools?

Now online: two resources on thoughtfully integrating generative AI into research training.

📄 Conceptual framework: zenodo.org/records/18649847
📋 Practical guide: zenodo.org/records/18452319

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Painting Cells with Science: How High-Content Imaging is Changing the Game CU Anschutz researchers are using fluorescence microscropy to paint cells to analyze images and detect cell differences.

Jenna Tomkinson from CU Anschutz led a hands-on Cell Painting workshop at National Jewish Health, showing how image-based profiling can reveal disease-linked patterns and open the door to new partnerships in discovery.

researchers or medical professionals working in an office, one (left) looks through microscope while the other (right) works on a notebook and a computer

Researchers at @cuanschutz.bsky.social are examining methods to overcome challenges in personalized oncology.

In a recent perspective, the researchers explore hybrid models (mechanistic + ML) to improve model fits and potentially prediction. Learn more➡️ https://cudbmi.info/personal-oncology-JAMIA-1

binary numbers overlayed with transparency English language dictionary white black gray

You may not know what NLP is, but it's very prevalent in our lives.

@compbiologist.bsky.social, PhD, associate professor @cuanschutz.bsky.social explains NLP and how he uses it to help biomedical data be reused for new discoveries. Learn more➡️ https://cudbmi.info/natural-language-processing-1

scientists in lab coats and masks operating in a laboratory with computers, technology, and other research methodologies like microscopes

Interdisciplinary research is challenging but vital for innovation and better patient outcomes. The latest JAMIA issue highlights this approach, with @cuanschutz.bsky.social researcher David Albers, PhD, as associate guest editor.
Read more➡️ https://academic.oup.com/jamia/article/33/1/1/8408480

Person in a lab coat studying notes and working on a laptop, surrounded by illustrations of a globe, molecular structures, and icons representing digital technology and questioning.

AI is rapidly reshaping clinical care. CU Anschutz researcher Yanjun Gao, PhD, explores how we can ensure these AI tools are safe, transparent and aligned with human needs. Learn more here ➡️ https://cudbmi.info/health-ai-2026-1

phoenix package logo in hexagon among 'wall of software' where there are other hexagonal logos of software tools

phoenix supports researchers in implementing Phoenix & Phoenix-8 pediatric sepsis scoring—providing more reproducible research and findings that translate into better care over time. Learn more about the tool developed by researchers @cuanschutz.bsky.social➡️ https://cudbmi.info/phoenix-package-1

woman with a microscope between 'neural network' with symbols inside representing computational models for cross-species knowledge transfer

Computational methods are improving how we translate discoveries from model organisms to humans. Researchers including @compbiologist.bsky.social propose agnology: “agnostic” to evolutionary history, driven by data. Learn more➡️ https://cudbmi.info/computational-methods-human-disease-1

woman with a microscope between 'neural network' with symbols inside representing computational models for cross-species knowledge transfer

Computational methods are improving how we translate discoveries from model organisms to humans. Researchers including @compbiologist.bsky.social propose agnology: “agnostic” to evolutionary history, driven by data. Learn more➡️ https://cudbmi.info/computational-methods-human-disease-1

Meet the Claw Lab, where researchers partner with the community to build a stronger foundation for ethical, collaborative and adaptive personalized medicine ➡️ https://cudbmi.info/claw-lab-1

A collage of diverse professional fields including genetics, digital technology with a person at a workstation, laboratory research, and medical review with text labeled "Softcare Almonds."

Every breakthrough in 2025, from new ICU guidelines to building one of the most complete human genome maps, reflects the power of working together to improve lives. Discover the stories behind the impact ➡️ https://cudbmi.info/top-stories-2025-1

Person receiving oxygen treatment while lying in a hospital bed, with medical equipment and flowers nearby.

Researchers at CU Anschutz created an automated system that continuously collects ventilator waveforms and links them with patient health records. Explore what this means for ICU care ➡️ https://cudbmi.info/data-pipeline-ventilator-waveforms-1

Promotional graphic for CCPM Seminar Series featuring DBMI Faculty, including speakers Katrina Claw, PhD, and Randi Johnson, MPH, PhD. Scheduled for 12 PM, September 25, 2025, available onsite and via Zoom. Information at ucdmbi.info/ccpm-seminar-2025-1

📢 CCPM Seminar Alert! Join us Tuesday, Dec. 9 at noon for an insightful session with Katrina Claw, PhD, and Randi Johnson, PhD, MPH.

➡️ Details here: https://cudbmi.info/ccpm-seminar-2025-1

Group of six diverse people smiling and standing outdoors, trees in the background.

Personalized medicine isn’t the future—it’s happening now. The Claw Lab at CU Anschutz is delivering culturally tailored, science-driven healthcare solutions that honor both biology and community knowledge. Meet the team behind the research ➡️ https://cudbmi.info/claw-lab-1

The 1% That Makes All the Difference: Understanding Polygenic Risk Scores Discover how tiny genetic differences shape disease risk. Learn what polygenic risk scores are, why they matter, and their role in personalized medicine.

If you knew your DNA hinted at a higher risk for future disease, would it change how you live today? By analyzing thousands of genetic variants, Polygenic Risk Scores provide a snapshot of your potential disease risk.

Joel Stoddard, MD, is on a mission to catch mood disorders before they take hold.

His research at CU Anschutz combines brain imaging, behavioral insights and machine learning to identify patterns that could predict mood disorders early, opening the door to faster and more effective interventions.

Rewriting the Rules of Disease Research: How Multi-Omics and Microbiomes are Revolutionizing Our Understanding of Health and Illness CU Anschutz researcheres explore how genes, gut microbes and multi-omics research shape overall health and diseases like asthma.

🔍 What if the key to managing disease isn’t just in your DNA? CU Anschutz researcher Maggie Stanislawski is utilizing multi-omics and microbiome science to investigate how genes, microbes, and molecules interact to influence health.

How Are Patients Using Healthcare Chatbots? Study Finds Some ‘Eye-Openers’ Researchers found a healthcare platform's chatbot was utilized by users for sensitive conversations alongside administrative tasks, assuming it was a neutral third party.

Patients trust chatbots for more than scheduling. A CU Anschutz study found many use UCHealth’s Livi for sensitive topics like mental health and billing, citing anonymity.

A detailed table displaying statistical data comparing health outcomes between two groups, with columns for baseline characteristics, cases per 100 person-years, and adjusted HR (95% CI). The table includes variables such as age, sex, body mass index, smoking status, and various health conditions, each accompanied by graphical representations of the data.

A new study of nearly 10,000 COVID-19 survivors in Colorado and Utah found that patients who received remdesivir during hospitalization had:
✅ 27% lower risk of death after discharge
✅ Fewer hospital and ER readmissions within 28 days

Explore the study ➡️ https://cudbmi.info/covid-rdv-2025-1

A patient resting in a hospital bed connected to a monitor displaying vital signs.

Mechanical ventilation saves lives, but can also cause ventilator-induced lung injury (VILI). A new study from CU Anschutz introduces a computer model that predicts VILI using early lung function data, outperforming traditional measures ➡️ https://cudbmi.info/vent-lung-injuries-1

Thrilled to see our primary and secondary faculty sharing their expertise at #AMIA2025! From AI in health to genomics and clinical informatics, their work is shaping the future of healthcare.

Check out their sessions and join the conversation ➡️ https://cudbmi.info/amia-2025-1

Synthetic Data Powers Breakthrough in Radiology AI at CU Anschutz Researchers at CU Anschutz have developed a privacy-preserving AI method using synthetic data to automate radiology documentation for thyroid nodules.

CU Anschutz researchers are utilizing synthetic data to train open-source AI models that automate radiology reporting, ensuring patient privacy is not compromised. Their new tool, AIDA, is already helping radiologists save time and focus on patient care.

A hand holding a smartphone displaying a chat interface with a message that reads, "How can I help you this afternoon?" The chat name displayed is "Claude Opus 4" and there's a floral-like icon at the top center of the screen.

Yanjun Gao, AI researcher at CU Anschutz, shares a critical insight: AI chatbots often mirror user input without verifying it against the literature. Her insights featured in @natureportfolio.nature.com ➡️ cudbmi.info/ai-sycophancy-1

Four people wearing ArchSwtz t-shirts standing together and posing with playful hand gestures in front of a brick wall outdoors.

A person stands at a podium presenting at the USRSE'25 conference in Philadelphia, PA, USA, with a slide titled "Software Gardening Almanack" featuring a sunflower image behind them. Audience members are seated, observing the presentation.

Four people wearing CU Anschutz t-shirts smiling in front of a building, with a reflection visible in the window behind them.

🌱 Dave Bunten and the DBMI software engineering team presented the Software Gardening Almanack at #USRSE2025. This tool was built to support sustainable research software.

Learn how DBMI is cultivating reusable, renewable software for science ➡️ cudbmi.info/softwaregarden-1