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Chris Toseland

@christoseland

Prof. Cancer Biophysics at University of Sheffield. Investigating Nuclear Myosin, Nuclear Organisation and Mechanobiology in Cancer with single molecule Biophysics Web: Toseland-lab.com

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19.10.2023
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Latest posts by Chris Toseland @christoseland

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Save the date!
We have an exciting conference coming up next year for the UK Mechanobiology community!

23.02.2026 18:13 πŸ‘ 17 πŸ” 8 πŸ’¬ 0 πŸ“Œ 1
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It was great to collaborate with Javier Redondo MuΓ±oz in this project and I am very happy to see it in press:

www.cell.com/cell-reports...

23.02.2026 18:12 πŸ‘ 10 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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We are very proud that Thalia has been nominated for three Yorkshire Choice awards - Please vote here: www.yorkshirechoiceawards.co.uk/vote

Three years ago, Thalia was diagnosed with a devastating brain tumour. She has fought back and done her best to raise awareness and funds to support others!

13.02.2026 19:32 πŸ‘ 9 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0

Registration deadline 20th Dec! We have generous travel grants for early career researchers! April is a beautiful time to visit China!

28.11.2025 17:04 πŸ‘ 13 πŸ” 7 πŸ’¬ 1 πŸ“Œ 1
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Biomolecular condensates: organizers of cellular biochemistry - Nature Reviews Molecular Cell Biology In addition to membrane-bound organelles, eukaryotic cells feature various membraneless compartments, including the centrosome, the nucleolus and various granules. Many of these compartments form thro...

The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…

1. Introduced a broad definition of β€œbiomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.

17.11.2025 07:24 πŸ‘ 36 πŸ” 14 πŸ’¬ 1 πŸ“Œ 2
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🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply πŸ˜‰
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨

#PhD #3DGenome

15.11.2025 09:52 πŸ‘ 36 πŸ” 37 πŸ’¬ 0 πŸ“Œ 3

In this work we show that you don’t have to target the main players in disease….instead you identify and target what they depend on!

15.11.2025 10:31 πŸ‘ 8 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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We're still accepting submissions for our 'Cell Biology of the Nucleus' special issue, which is being guest edited by
@abbybuch.bsky.social and Megan King (@luskinglab.bsky.social).
Submission deadline: 5 January
journals.biologists.com/jcs/pages/nu...
#nucleus #notforprofit #freetopublish

13.11.2025 17:13 πŸ‘ 29 πŸ” 13 πŸ’¬ 0 πŸ“Œ 1

Thanks @grosselab.bsky.social there is another nice one coming soon!

14.11.2025 14:45 πŸ‘ 3 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells. https://www.biorxiv.org/content/10.1101/2025.11.13.688007v1

14.11.2025 03:48 πŸ‘ 1 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Perturbation of Myosin VI enhances the effect of endocrine therapies. Moreover, Myosin VI is still required for hormone-independent ER mutants thereby providing a potential avenue to overcome therapy resistance.

14.11.2025 09:33 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast
cancer cells. www.biorxiv.org/content/10.1...

We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.

14.11.2025 09:33 πŸ‘ 21 πŸ” 10 πŸ’¬ 1 πŸ“Œ 2
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MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool, l...

A PhD position is available in the lab of @zech-lab.bsky.social co-supervised @christoseland.bsky.social

An exciting project to understand cellular ageing in health and disease www.findaphd.com/phds/project...

#CellBio #SuperResolutionMicroscopy
#MolecularBio #AgeingResearch #PhDOpportunity

13.11.2025 10:25 πŸ‘ 2 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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πŸ”¬Want to develop a blood test for dementia? A fully funded PhD position is available in our lab to probe and detect single molecules! Join our team @york.ac.uk
! Find out more & apply by 4th Dec:

tinyurl.com/yt36p9tx

@ybri-uoy.bsky.social @ei-science.bsky.social @timcraggs.bsky.social

31.10.2025 16:13 πŸ‘ 3 πŸ” 4 πŸ’¬ 1 πŸ“Œ 0
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Please repost - Multiple PhDs available

www.findaphd.com/phds/project...

www.findaphd.com/phds/project...

www.findaphd.com/phds/project...

05.11.2025 09:18 πŸ‘ 37 πŸ” 55 πŸ’¬ 1 πŸ“Œ 1
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MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool, l...

Please Repost!

Tobi Zach and I have an MRC DiMeN PhD position available! Come join us!

www.findaphd.com/phds/project...

02.11.2025 11:13 πŸ‘ 4 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0
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It’s Halloween so time to make the cells scream!

31.10.2025 08:23 πŸ‘ 32 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Excited for our next special issue and looking forward to working with Abby Buchwalter (@abbybuch.bsky.social) and Megan King (@luskinglab.bsky.social)! Working on the cell biology of the nucleus? Send your papers our way!
#notforprofit

16.07.2025 15:55 πŸ‘ 23 πŸ” 17 πŸ’¬ 0 πŸ“Œ 0

Phantastic review of SPT method and analysis. Great resource for every single molecule tracking enthusiast! Congratulations, @gebhardtlab.bsky.social

10.07.2025 08:18 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Yesterday we had the School of Medicine and Population Health PGR symposium - a fantastic range of talks and posters from our students!

We had excellent career sessions from Faith Nutter Howard David King and Amy Turner

Thanks to our ECRs who gave a useful and honest take on finishing a PhD.

09.07.2025 06:54 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Intracellular mechanics and organelle mechanobiology Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…

Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! πŸ™ #EMBOmechanobio

meetings.embo.org/event/26-org...

04.07.2025 15:50 πŸ‘ 71 πŸ” 45 πŸ’¬ 1 πŸ“Œ 5
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Doubling up on the measurements and toys today - so great and useful to have this kit next door to each other!

03.07.2025 16:05 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Postdoc positions open in my lab (Francis Crick Institute) to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

20.06.2025 09:38 πŸ‘ 77 πŸ” 80 πŸ’¬ 1 πŸ“Œ 2
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This is a piece that I and @karsten-rippe.bsky.social discussing a lot, and a topic that is very close to my heart. The editors @naturerevgenet.bsky.social gave us the stage to do so, and the final version of our review is now available under this link: rdcu.be/erP1u

A short thread follows 1/n

19.06.2025 16:37 πŸ‘ 95 πŸ” 39 πŸ’¬ 3 πŸ“Œ 2
A graphic of an outline of a shield filled with photographs of students, teachers, academics and other members of the University of Sheffield community. The QS logo is prominently displayed near the bottom of the shield. Underneath is written β€˜The University of Sheffield Top 100 QS World University Rankings 2026’

A graphic of an outline of a shield filled with photographs of students, teachers, academics and other members of the University of Sheffield community. The QS logo is prominently displayed near the bottom of the shield. Underneath is written β€˜The University of Sheffield Top 100 QS World University Rankings 2026’

The QS World University Rankings 2026 have just been released and we’ve placed 92nd within the World Top 100! Huge congratulations and thanks to everyone in the University of Sheffield community for this achievement; from staff and students to alumni, supporters and friends around the world!

19.06.2025 06:59 πŸ‘ 18 πŸ” 9 πŸ’¬ 0 πŸ“Œ 7
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πŸš€ Manual mask annotation slowing you down?
πŸ’‘ SAMJ is a new ImageJ/Fiji plugin using Segment Anything (SAM) for fast, interactive segmentation β€” no GPU needed, one-click install, real-time results.
πŸ”¬ Perfect for large biomedical images.
arxiv.org/abs/2506.02783
#AI #Bioimaging #ImageJ #OpenSource

17.06.2025 08:16 πŸ‘ 56 πŸ” 13 πŸ’¬ 1 πŸ“Œ 0
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If heterochromatin is really a liquid-like condensate, why is it not spherical?
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...

16.06.2025 18:16 πŸ‘ 89 πŸ” 25 πŸ’¬ 5 πŸ“Œ 3

Amazing news - many congrats!

07.06.2025 10:52 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Needing to be everywhere all at once….Drove down at lunch with the samples

06.06.2025 18:53 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Back again!

06.06.2025 15:56 πŸ‘ 5 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0