Targeting replication stress in neuroblastoma by exploiting the synergistic potential of second generation RRM2 and CHK1 inhibitors
www.nature.com/articles/s41...
05.03.2026 18:28
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Targeting replication stress in neuroblastoma by exploiting the synergistic potential of second generation RRM2 and CHK1 inhibitors
www.nature.com/articles/s41...
Check out our new paper from @dkfz.bsky.social in which we found a suprising role of cIAP1 inhibitor of apoptosis (BIRC2) as tumor suppressor in Ewing #sarcoma
www.sciencedirect.com/science/arti...
Around 16 people are diagnosed with sarcoma every day in the UK. Sarcoma UK and Rare Disease Day logos.
That is around 5,900 diagnoses each year. Graphic of 5 people icons.
Sarcoma includes both bone sarcoma and soft tissue sarcoma. Roughly 1 in 8 sarcoma diagnoses are bone sarcoma.
Find the latest UK sarcoma statistics on our website. Visit: sarcoma.org.uk/newincidence. Sarcoma UK logo.
Sarcoma is a rare cancer that can affect any part of the body, including muscle, bone, tendons, blood vessels and fatty tissues.
On Rare Disease Day, we’re sharing the latest UK statistics to help improve understanding of sarcoma.
sarcoma.org.uk/newincidence
Two Manchester marathon runners post-run wearing medals.
More places are now available for the Manchester Marathon with #TeamSarcoma!
📅19 April 2026
Sign up today sarcoma.org.uk/manchester
New work from our lab, hot off the press in Nature Immunology (@natureportfolio.nature.com)!
How do human T cell responses diversify — and how does this lead to durable protection after vaccination?
Paper: www.nature.com/articles/s41...
Press release: www.fau.eu/2026/02/news...
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Daniel Gerber auf Mastondon:
Überweisung des Bundes an Microsoft: Was macht das mit euch?
2023: 274.091.361,75 Euro
2024: 347.665.579,71 Euro
2025: 481.369.660,77 Euro
Man stelle sich vor, was mit 1.103.126.602,23 € an Open Source Software in D hätte beschafft und entwickelt werden können.
Easily translate your research question into a great looking figure in the open online R2 genomics analysis and visualization platform r2platform.com
Created for biomedical researchers / #PhD students
#ScienceCommunication #ScienceForAll
R2 is also great for #ScienceEducation
Please register for the next EuSARC conference in Oslo, Norway!
www.eusarc.net
Intratumor Heterogeneity and Clonal Evolution in Sarcomas: Molecular, Cellular, and Functional Drivers of Therapy Resistance
www.sciencedirect.com/science/arti...
Happy International Day of Women&Girls in Science!
Meet the wonderful women of @alteamanzanolab.bsky.social Cristina - Gwen - Vanesa - Lisbeth - Maria Luisa - Bruna - Maria 👩🔬🔬
#InternationalDayofWomenandGirlsinScience
Super happy that our lab @dkfz.bsky.social has contributed to the largest Ewing sarcoma GWAS to date:
Genome-wide association study meta-analysis identifies susceptibility loci informing Ewing sarcoma etiology and potential mechanisms of risk
medrxiv.org/cgi/content/short/2026.02.06.26345779v1
Congratulations, Alice!
Happy to share this new, very intentional chapter. I have left UCLA after 14 years to join the University of Colorado Anschutz as Professor of Biomedical Informatics and Neurosurgery and the inaugural Marsico Chair in Excellence in Functional Precision Medicine/n
news.cuanschutz.edu/dbmi/cu-ansc...
Working on trans-eQTL mapping with population-scale scRNA-seq? Meet LIVI, our latest framework that enables efficient trans-eQTL mapping at single-cell resolution across cohorts of hundreds to thousands of donors.
Preprint: doi.org/10.64898/202...
Summary in the 🧵 below by @danaivagiaki.bsky.social
Very happy to share our new study defining the ontogeny of Thetis cells and the developmental cues that shape their early-life wave of differentiation. www.nature.com/articles/s41... Beautiful work led by @hhmi-science.bsky.social Gilliam Fellow Yoselin Paucar Iza and postdoc Tyler Park 1/
When you agree to serve in a committee
The time of day for cancer immunotherapy is associated with major outcomes. Early is better. Results from a randomized trial of lung cancer, backs up the importance of our circadian rhythm and immune system
www.nature.com/articles/s41...
We invite applications for a Tenure Track Professorship (W1->W3) in Molecular Biology @ZMBH. We are looking for excellent postdocs, ready to start their own research group. Feel free to spread the news by reposting.
Applications can be filed until January 18th.
www.nature.com/naturecareer...
Excited to share my paper published today in @cp-immunity.bsky.social! We find that when CTLs integrate antigen and cytokine signaling, the timing of these cues matters - shedding light on an old question: Why do NK cells sometimes behave like CD8+ T cells?
www.sciencedirect.com/science/arti...
Glad to share good news from the rEECur trial team (trial for patients with relapsed/ refractory Ewing sarcoma). A new trabectedin arm will open this year offering access to a potentially more effective and less toxic drug combination, providing better quality of life. Read more here bit.ly/4rovr7j
I am pleased to share our latest paper on the role of the alternative polyadenylation factor CFIM-1 (NUDT21) in C. elegans germline development. academic.oup.com/genetics/adv...
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⚽14 cross-border energy projects.
🥅 One goal: clean, affordable energy for everyone.
Discover them 👇
Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma
www.cell.com/iscience/ful...
Graphic illustration on a textured blue background featuring a white clenched fist holding a wind turbine like a torch. Glowing blue and white electrical bolts spark out from behind the turbine. The text "Taking Europe's Energy Back" curves across the top in white and green lettering. In the bottom right corner, there is a white outline of the European Union flag.
Clean energy isn’t a talking point.
It’s already powering Europe.
💡 Nearly half of Europe's electricity came from renewables in 2024.
💡 We saved €120 billion through energy efficiency measures.
💡 And in June 2025, solar became the EU's largest power source for the first time in history.
Congratulations!!!
I am very excited to share that I am transitioning to the Center for Cancer and Immunology Research at Children's National Hospital, where I will be opening my Lab this spring. #PediatricCancer #Zebrafish #Development #TME
Together with Jeroen Krijgsveld, we are looking for a postdoc to help us unlock single-cell proteomics (SCP) through the establishment of a scalable computational framework.
For more information, see the @hlsalliance.bsky.social Postdoc Program:
www.health-life-sciences.de/opportunitie...
We are very proud on our fantastic postdoc Dr. Eleonora Prodi who has been awarded with a prestigious Humboldt-fellowship of @humboldt-foundation.de for her research project @dkfz.bsky.social and @KiTZ on developing a new virotherapy for kids affected by sarcomas!
pre-print + review = publication
q.e.d
