Beautiful new UK Wnt paper out now in @natgenet.nature.com
by Peter Hohenstein, Andrew Wood and Derya Ozdemir
@unileiden.bsky.social @edinburgh-uni.bsky.social and Koc University characterising the impact of numerous CTNNB1 mutational variants in human cancer.
www.nature.com/articles/s41...
New UK Wnt paper out in @natgenet.nature.com from the Owen Sansom group at @cruk-si.bsky.social showing the RNA-binding protein NPM1 supports WNT-driven intestinal and liver tumorigenesis.
www.nature.com/articles/s41...
Congratulations Yaser! We love to see any Wnt project funded!
Very grateful to receive a new BBSRC grant and many thanks to #BBSRC panel, and reviewers for thisΒ generous support. This funding will enable us to address important unresolved questions in chromatin regulation downstream of WNT/GSK3 signalling in stem cells. @wntuk.bsky.social
New posdoc position available in the Guettler lab @icr.ac.uk studying ADP-ribosylation in Wnt/B-catenin signalling and telomere maintenance πππ
jobs.icr.ac.uk/vacancies/12...
My next stop is CRUK Scotland in Glasgow. Thanks to Owen Sansom @cruk-si.bsky.social for hosting me. The @wntuk.bsky.social community is just awesomeβgreat people, excellent research!
If you are interested in helping to organise and shape this event, I would love for you to join me!
Calling all WntUK ECRs! As the vision for a 2026 Wnt meeting takes shape we're planning a one-day ECR event.
Interested in helping shape and organise it alongside our ECR rep @nadianasreddin.bsky.social?
A great opportunity to connect, contribute, and develop your career. Get in touch!
Our latest work out now in Oncogene by Dr Megan Wagstaff at @biochembiomeduos.bsky.social @sussex.ac.uk @sussexcancer.org @sussexbcr.bsky.social @wntuk.bsky.social. We show the oncogene Ξ²-catenin interacts with a Wnt mRNA network in myeloid leukaemia cells
Quickπ§΅π 1/
www.nature.com/articles/s41...
Major congrats to Dr#3 from our group Okan Sevim who passed his PhD viva yesterday.
A super talented researcher, itβs been a privilege to serve as Okanβs supervisor from MSc to PhD in @biochembiomeduos.bsky.social @sussex.ac.uk
Many thanks to examiners @mitchell.science & @mardakheh.bsky.social
Such an honour! Thank you to the organising committee for the opportunity and the great conference!!
As the sun sets on a wonderful day of celebrating @wntuk.bsky.social research, we want to thank all attendees, presenters and sponsors for making this possible. @oxfordcancer.bsky.social, The Company of Biologists, Cambridge Biosciences, @thermofishersci.bsky.social
Honoured and humbled to win Best Talk at #WNTUK2025! This work reflects years of dedication and a fantastic team effort, led by the amazing Hayley Belnoue-Davis and myself, under the brilliant Simon Leedham. Grateful to allβsoon to be in press! π
Thank you for the opportunity to contribute; what a fantastic meeting hosted at the inspiring Oxford, on the coolest signalling pathway.
Really enjoyed #WNTUK2025 at @ox.ac.uk in beautiful Worcester College today. Excellent program of research talks and posters put together by @michaelranes.bsky.social and @oxfordcancer.bsky.social representing all themes, career stages and gender/diversity of @wntuk.bsky.social research. π
And thatβs a wrap! @michaelranes.bsky.social draws a highly enjoyable, well organised and stimulating 2nd WNTUK meeting to a close, followed by drinks in the sun in front of a beautiful Worcester College lawn. See you next year!
#WNTUK2025
Congratulations to @eoghanjm.bsky.social from @ox.ac.uk on winning best talk, and Kieran Hodson from the Toby Phesse group at @cardiffuni.bsky.social @ecscri.bsky.social on winning best poster!
#WNTUK2025
The final talk of the day is our international keynote speaker @michaelboutros.bsky.social from @dkfz.bsky.social @uniheidelberg.bsky.social presenting a past and present overview on mechanisms of Wnt signal transduction.
#WNTUK2025
The penultimate talk of the day is our best selected PhD talk by Dr Ben Broadway from the Guettler lab at @icr.ac.uk presenting on CRISPR approaches to uncovering new tankyrase regulatory mechanisms in Wnt/B-catenin signalling.
#WNTUK2025
Many thanks WntUK ECR rep @nadianasreddin.bsky.social from @cruk-si.bsky.social for chairing the Future Generation session!
#WNTUK2025
The final session of the day is a Future Generation focus starting with invited ECR speaker Dr Yeonjoo Kim from the @ianmcgough.bsky.social group at @babrahaminst.bsky.social presenting on a novel RASopathy caused by hyperactive non-canonical Wnt signalling.
#WNTUK2025
Final talk of the disease session is a selected abstract from Nico Mueller of the de la Roche group at @cambridgeuni.bsky.social @cruk-ci.bsky.social speaking about novel LGR5 immunotherapeutics against multiple cancer types.
#WNTUK2025
Next up another selected abstract this time from Dr Nuray Gunduz at the Sansom group at @cruk-si.bsky.social presenting her research on LGR4 maintenance of intestinal homeostasis and protection from mutant-cell clonal expansion.
#WNTUK2025
Many thanks to @yatlasi.bsky.social from @qubelfastofficial.bsky.social for chairing the Disease and Translational Research session.
#WNTUK2025
The Disease & Translational Research session begins with invited speaker Dr @vivianlilab.bsky.social from @crick.ac.uk presenting on SOX2 driven fetal reprogramming and reversible dormancy in colorectal cancer.
#WNTUK2025
Lunch break means itβs WntUK poster time!
We have 17 fabulous posters here today covering Wnt signalling across mechanisms, development and disease from all career stages.
#WNTUK2025
Weβve paused for a glorious lunch break!
The final session before lunch is a selected abstract from Lee Placito Fellow of GI Cancer @eoghanjm.bsky.social from the @leedham-simon.bsky.social group at @ox.ac.uk speaking about GREMLIN1 role in stromal remodelling of Wnt-dependent ectopic stem niches in the intestine.
#WNTUK2025
Taking us into the afternoon is the third selected abstract from Dr Ines Alvarez Rodrigo from the @jpvincentlab.bsky.social at the @crick.ac.uk presenting her research on Wnt secretion mechanisms at the membrane.
#WNTUK2025
Many thanks to Dr Florencia Cavodeassi from @citystgeorges.bsky.social for chairing the Wnt Signalling in Development session.
#WNT2025
