π @belenpachano.bsky.social from @siegel-lab.bsky.social has been awarded the Marie SkΕodowska-Curie Actions (MSCA) fellowship @ec.europa.eu . π
She investigates how #pathogens evade the #host #immune #system through #antigenic #variation.
β‘οΈ www.med.lmu.de/bmc/en/news/...
πΈ: Siegel Lab
π₯³ I still canβt quite believe this is real: Iβve been awarded a Marie SkΕodowska-Curie Postdoctoral Fellowship (#MSCA) with a 100% evaluation score.
Excited for whatβs ahead at @lmu.de (@bmc-lmu.bsky.social) in the @siegel-lab.bsky.social β¨
Nature Com. now live! π Silviaβs amazing PhD supervised by Alex βthe Greatestβ & Christopherβs big-bang contribution. Huge thanks to our stellar team & collaborators. We went fishing in the FDA pond and hooked LY2090314 π£ Blocks GSK3 π―in #Toxoplasma & #Crypto
www.nature.com/articles/s41...
Closing 4 wonderful years of PhD in the ParaFrap & EMBO Workshop in a beautiful french island. Thank you @hakimi.bsky.social and @parafrap.bsky.social for this wonderful learning journey π
Iβm excited to share our new preprint!
Weβve been investigating a specific domain in TgSNF2L that forms decamers in vitro. Every time we attempted to break them apart, they just snapped back together. That tenacity earned it the nickname Hydra. π
π www.biorxiv.org/content/10.1...
Zeus had his Hydra βοΈ, now Toxoplasma has its own.
Meet Hydra: not a monster, but a brand-new protein domain.
It multimerizes like crazy & rewrites the chromatin landscape 𧬠in Toxoplasma.
Our team and colleagues from @embl.org #Grenoble just dropped the preprint π
www.biorxiv.org/content/10.1...
Thrilled to share our latest review! π It captures the ideas and discussions that have shaped our work in recent years. Big shoutout to the amazing authors π @hakimi.bsky.social
www.sciencedirect.com/science/arti...
Thank you for providing me an amazing environment to learn and work. I could not have asked for a better mentor!
Glad to have contributed to this amazing work out now in
@embomolmed.org ! π Big shoutout to Marie G. Robert & Christopher Swale and @hakimi.bsky.social !
www.embopress.org/doi/full/10....
𧡠Ever wondered what Toxoplasma is doing in your brain years after that undercooked steak π₯© or a sip of contaminated water? Turns out, it's been hiding in your brain π§ and we finally have a way to spot it. New study just dropped in EMBO Molecular Medicine π
doi.org/10.1038/s443...
An ISWI-related chromatin remodeller regulates stage-specific gene expression in #Toxoplasma gondii. By Belen Pachano (ParaFrap PhD student) et al., team @hakimi.bsky.social. In @natmicrobiol.nature.com www.nature.com/articles/s41...
Open Sesame: The Protein Behind Parasite Stage Switching
"To make sense of this genomic jungle, the parasite relies on an extra layer of regulation to ensure precise gene activation at the right time and in the right place"
go.nature.com/3RJNMfb
Thrilled to share my first paper, now out in
@natmicrobiol.nature.com! Huge thanks to my amazing supervisor @hakimi.bsky.social and everyone who contributed to this work!
www.nature.com/articles/s41...
In the silence of chromatin, Toxoplasma whispers change.
TgSNF2h sculpts the genome - MORC in the backseat.
Some genes wake. Others sleep.
A dance of nucleosomes shaping space for life parasite stages to unfold.
Now in Nature Microbiology:
rdcu.be/ehkWp
A humorous reflection on the first article from my stellar PhD student, Belen Pachano.
communities.springernature.com/posts/open-s...
