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Neelima Thottappillil

@nthottappillil

Postdoctoral fellow @HopkinsMedicine| Studying blood vessels, stem cells and bone #HumaninSTEM | Alumnus @SCTIMST @EdinburghUniv | #FilledwithLaughter

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16.11.2024
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Latest posts by Neelima Thottappillil @nthottappillil

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Considerations in the Use of Mouse Models of Vascular and Valvular Calcification | Arteriosclerosis, Thrombosis, and Vascular Biology CLINICAL PROBLEM: Vascular and valvular calcification significantly contributes to cardiovascular morbidity, particularly in patients with diabetes, atherosclerosis, advanced age, and chronic kidney d...

Considerations in the Use of Mouse Models of Vascular and Valvular Calcification

Our new article is now published ⁦‪in ATVB @ahascience.bsky.social

www.ahajournals.org/doi/10.1161/...

04.03.2026 00:13 👍 11 🔁 5 💬 0 📌 0
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What are Markers of arterial adventitial fibroblast?
PDGFRA
DPEP1

3 fibroblast subsets
CD55+
LOX+
CXCL14+

CD55+ adventitial fibroblasts are enriched in thoracic aorta & carotid artery, but rare in other large arteries

#CardiovascRes 2023
academic.oup.com/cardiovascre...

28.01.2026 20:43 👍 7 🔁 2 💬 0 📌 0
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Spatial Transcriptomics !!

21.01.2026 19:01 👍 5 🔁 1 💬 0 📌 0
Miso, a 6-year-old male border collie from Canada, that knows the names of about 200 toys.

Miso, a 6-year-old male border collie from Canada, that knows the names of about 200 toys.

A group of “gifted word learner” dogs can learn new words that label objects by overhearing their owners talking with each other, according to a new study in Science. https://scim.ag/3L3mhha

12.01.2026 20:43 👍 48 🔁 8 💬 1 📌 6

WooHoo!! Thank you @haoyin.bsky.social

02.01.2026 19:47 👍 1 🔁 0 💬 1 📌 0
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A 5-day protocol to generate hiPSC 3D Vascular Organoid😎
ETV2▶️Endothelial Cell
NKX3.1▶️Mural Cell

👉Perfusable, arteriovenous network in vivo
👉⏫Reperfusion in mouse diabetic limb ischemia
👉⏫transplanted islet performance

@meleromartinlab.bsky.social #CellStemCell 2025
www.cell.com/cell-stem-ce...

14.12.2025 12:53 👍 15 🔁 4 💬 0 📌 0

Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!

20.11.2025 13:22 👍 57 🔁 17 💬 3 📌 2
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Beautiful work on renal microvascular mural cells from @ondinecleaver.bsky.social
#SciArt

Tbx18+ ureteric stromal progenitor at E13.5 contributes to renal arterial/arteriolar NG2+ αSMA- mural cells & inner cortical NG2+ capillary pericyte

@devbiol.bsky.social
www.sciencedirect.com/science/arti...

20.11.2025 13:01 👍 7 🔁 1 💬 0 📌 0
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Flow sorting of Perivascular Mesenchymal Progenitor Cells from human Adipose Tissue

Pericyte CD146+CD34−CD31−CD45−
Adventitial progenitor CD34+CD146−CD31−CD45−

What are those CD34+CD146+CD31−CD45− cells?😁

@nthottappillil.bsky.social #MethodsMolBiol 2024
link.springer.com/protocol/10....

02.11.2025 22:02 👍 7 🔁 1 💬 1 📌 0

@haoyin.bsky.social Those cells can be a pool of pericyte and adventitial cells, but yet to characterise, excellent idea. Ty

03.11.2025 14:58 👍 1 🔁 0 💬 0 📌 0
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Microcalcification in Vasa Vasorum of Unruptured Intracranial Aneurysm

#SciArt #CaseReport
44 y/o ♂️ Likely #T2D

Calcified emboli in microvessels of cerebral arteries!?😆

Anne Robertson lab #SciAdv 2025
www.science.org/doi/10.1126/...

01.11.2025 20:42 👍 2 🔁 2 💬 0 📌 0

Congratulations

25.10.2025 03:29 👍 1 🔁 0 💬 0 📌 0
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#Atherosclerosis Epitranscriptomics

Cell type-specific dysregulation of m6A machinery in atherogenic phenotypes
#EndothelialCell ALKBH5
#SmoothMuscleCell WTAP
Mφ METTL3 YTHDF2

Re-analysis of scRNAseq Wirka's Nat Med 2019
pmc.ncbi.nlm.nih.gov/articles/PMC...

#THNO 2025
www.thno.org/v15p4785.htm

14.10.2025 19:30 👍 4 🔁 1 💬 0 📌 0
Gaia and toys CREDIT Claudia Fugazza

Gaia and toys CREDIT Claudia Fugazza

With no prior training, dogs can infer whether a toy is for tugging or fetching, even when the toys don't look alike. www.cell.com/current-biol...

@currentbiology.bsky.social
Eötvös Loránd University Claudia Fugazza, Andrea Sommese, Ádam Miklosi

18.09.2025 15:00 👍 7 🔁 1 💬 0 📌 0
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As Vice Chair of the GRC Bones and Teeth, I am delighted to invite you to join us for our upcoming meeting, on January 25–30, 2026, at Hotel Galvez in Galveston, TX, a cherished venue for our conference.
We look forward to welcoming you to what is sure to be an exciting and memorable meeting!

11.09.2025 18:40 👍 11 🔁 4 💬 1 📌 0
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A new model of #TumorNecrosis👹

Tumor CXCL1➡️myeloid skewing➡️
Ly6C-low Neutrophil forms intravascular #NeutrophilExtracellularTrap➡️
Intratumoral vascular occlusion➡️
Pleomorphic Necrosis-to-Metastasis

a role of TGFβ
@adrover.bsky.social @megeblad.bsky.social Nature 2025
www.nature.com/articles/s41...

07.09.2025 19:12 👍 12 🔁 3 💬 0 📌 0

Poor thing just dozed off!!

19.08.2025 18:29 👍 1 🔁 0 💬 0 📌 0
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In his memory, Western has opened an equity-based graduate scholarship. Please consider supporting his final initiative if you are able: www.westernconnect.ca/beier ; thank you for all the time you spent and laughs you shared with him. We love and miss him so much already. - The Beiers

24.07.2025 15:09 👍 66 🔁 19 💬 2 📌 0
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Hi all. Frank passed peacefully with the love of his family on July 18, 2025 in London, ON. He was a wonderful human being who shared much of his life with you. We could not have asked for a better father, grandfather, friend, colleague, or mentor. 1/

24.07.2025 15:06 👍 105 🔁 14 💬 19 📌 4
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#VascualarBiology2025
Annual Meeting of NAVBO and the Microcirculatory Society!!
Join us on Cape Cod in Massachusetts!
October 19-23, 2025
Conference Abstracts are due August 4, 2025 by 5:00 pm ET.
Visit the conference website for more,
Register, and/or to submit an abstract www.navbo.org/vb2025/

23.07.2025 19:43 👍 4 🔁 3 💬 0 📌 0
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Smooth muscle cells and fibroblasts in the ascending aorta exhibit minor differences between embryonic origins in angiotensin II-driven transcriptional alterations - Scientific Reports Scientific Reports - Smooth muscle cells and fibroblasts in the ascending aorta exhibit minor differences between embryonic origins in angiotensin II-driven transcriptional alterations

Member publication alert:

Smooth muscle cells and fibroblasts in the ascending aorta exhibit minor differences between embryonic origins in angiotensin II-driven transcriptional alterations

www.nature.com/articles/s41...

18.05.2025 20:16 👍 2 🔁 1 💬 0 📌 0
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Connect with NAVBO on more platforms now !!

09.05.2025 17:45 👍 4 🔁 3 💬 0 📌 0
What we’ll be talking about at #VascularDiscovery25: From Genes to Medicine.

What we’ll be talking about at #VascularDiscovery25: From Genes to Medicine.

What we’ll be talking about at #VascularDiscovery25: From Genes to Medicine.

What are you most excited for?

22.04.2025 14:27 👍 5 🔁 4 💬 0 📌 0

Fantastic sessions at Vascular Discovery 2025. More exciting that it’s in Baltimore!!! @ahascience.bsky.social

24.04.2025 15:08 👍 1 🔁 0 💬 0 📌 0

Join the symposium to know more on Integrated transcriptomics of blood vessel by Prof Aaron W James and other latest findings from our lab!! @navbo.bsky.social

24.04.2025 14:41 👍 2 🔁 1 💬 0 📌 0
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Happening this Thurs Apr 10th at 1pm ET!! Join us for the #InFocusSession on Exploring Therapeutic Approaches in the Vasculature!! Speakers were selected from Abstracts submitted to VB2024! These sessions are NOT recorded so be sure to attend!! Register👉 shorturl.at/LkITp

07.04.2025 17:58 👍 3 🔁 4 💬 0 📌 0

This is real..To add to this, some women also bully other women in academic setting. May be they support misogyny? but wait they bully men too!! We should not forgive them either.

07.03.2025 00:31 👍 2 🔁 0 💬 0 📌 0
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Transcriptional activation of regenerative hematopoiesis via microenvironmental sensing - Nature Immunology Itkin et al. identify a role for Fli-1 in hematopoietic stem cell activation during regenerative hematopoiesis. They show that Fli-1 coordinates hematopoietic stem cells to stimulate niche-derived Not...

Transcriptional activation of regenerative hematopoiesis via microenvironmental sensing @natimmunol.bsky.social
www.nature.com/articles/s41...

25.02.2025 17:58 👍 12 🔁 2 💬 0 📌 0
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Vascular Cell Biology Gordon Conference - rescheduled to July 2025, co-chaired by our own @nicolilab.bsky.social

www.grc.org/vascular-cel...

25.02.2025 20:58 👍 3 🔁 1 💬 0 📌 0
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#SpatialTranscriptomics #Visium #Xenium
Glomerular microvascular cell landscape shift in #DiabeticKidneyDisease

MEF2A/MEF2C/TRPS1 in Glomerular #EndothelialCell phenotypic plasticity & EC-to-Mural cell/Podocyte communications
SEMA6A-PLXNA2

bioRxiv 2024
www.biorxiv.org/content/10.1...

13.02.2025 21:09 👍 10 🔁 4 💬 0 📌 0