Alessandro Costa

Do you work on DNA or RNA protein complexes? 🧬

Come to Machines on Genes this June in Crete! ☀️

Super early discount is ending this Sunday so register now! 😃

Super Early Bird deadline Sunday 8 Mar! Save €100
Register for Machines on Genes 2026 ⚙️🧬
Biochemical Society Harden Conference
📍 Heraklion, Crete | 8–11 June 2026 🌊☀️

www.eventsforce.net/biochemsoc/f...

Scientific organisers: Lori Passmore, Dana Branzei & Alessandro Costa

plus ...

Ana Casañal
Claudio Ciferri
Hitoshi Kurumizaka
Meindert Lamers
David Rueda
Yuanling Zhai
Xiaodong Zhang

🧬🔬✨❄️ 🧫⚗️🧑‍🔬🏖️

🌞✈️🇬🇷🏝️ 🧬 Machines on Genes 2026 🧬 🌞✈️🇬🇷🏝️

What an amazing list of speakers 🤩

@nynkedekkerlab.bsky.social
@dodonova-sveta.bsky.social
@yuanhejhu.bsky.social
@uwmadisonrna.bsky.social
@kowaeva.bsky.social
@fmattiroli.bsky.social
@aliciakmichael.bsky.social
@lisaracki.bsky.social
@yeeles-lab.bsky.social

🔔 Register now and send an abstract!

Lots of opportunities to talk!

👉 www.eventsforce.net/biochemsoc/f...

8–11 June 2026 | 📍 Heraklion, Crete 🇬🇷

Get ready for Machines on Genes 2026, the 94th Harden Conference by the @biochemsoc.bsky.social — four days of molecular mechanisms and friendly discussions! 🧬☀️🔬❄️

Organised by @lapassmore.bsky.social, Dana Branzei, me.

@nynkedekkerlab.bsky.social @dodonova-sveta.bsky.social @yuanhejhu.bsky.social @uwmadisonrna.bsky.social @kowaeva.bsky.social @fmattiroli.bsky.social @aliciakmichael.bsky.social @lisaracki.bsky.social @yeeles-lab.bsky.social

Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social

Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...

Postdoctoral Fellow - Costa Lab Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...

Less than two weeks left to apply!

Postdoc positions in my lab to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists & structural biologists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

Postdoc positions open in my lab (Francis Crick Institute) to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

Unidirectional MCM translocation away from ORC drives origin licensing Nature Communications - When the MCM motor of the replicative helicase becomes loaded onto chromatin, origin DNA is licensed for replication. Here, the authors show why the ATPase function of MCM...

How does ATP hydrolysis by MCM enable replicative helicase loading onto DNA?

Find the answer in our latest article

rdcu.be/d6D8D

Congratulations to Agata Butryn who led the entire project, with contributions from Julia Greiwe at the start. 🎉❄️🔬🧬

definitely, let's meet up. I will be doing my first cryoFIB experiment but will make time for a chat! It must be 7 years since I last saw you!

Thank you, Dan!

Amazing work, Jon.

Great to see this, Lucas. Congratulations!

Thank you, Alexey!

Could I afford you? is the appropriate question! ;-) BTW, it is only thanks to the work that you and your lab mates did over the years that I could receive this grant!

Thank you, Rob!

www.crick.ac.uk/news-and-rep...

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute.

Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!

3 postdoc positions advertised soon.

Well done, Gideon! Very well deserved.

Great work, Alex and colleagues!

Drew, breathtaking!

Thank you, Andrew!

Happy to be of help, Anna! 😀

Thanks Tim! Lucky to work with a great group of people!

Thank you, Francesca!

many thanks DNA Topology lab 😀!

Congratulations Alessandro and team!

This scheme shows the cargo adaptor FHF in the middle with arrows pointing to distinct microtubule and actin-based motors (dynein-dynactin, KIFC1, KIF1C and myosins V, IX and X as well as Tropomyosin 1). It also shows a link to Rab5 marked early endosomes. The hypothesis is that FHF coordinates multi motor binding at the early stages of endocytosis. The PhD project would address the hierarchy of motor binding and how these motors coordinate to allow the newly formed vesicle to transition from the actin to MT cytoskeletal network.

If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪