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Paul Flicek

@paulflicek

Data, genomics, evolution, science πŸ‡ΊπŸ‡ΈπŸ‡¬πŸ‡§

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19.11.2023
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Latest posts by Paul Flicek @paulflicek

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In memoriam: Philip Bourne, founding dean of the School of Data Science The leader, who propelled the school from a concept to national recognition, had battled mesothelioma.

Saddened to hear of Phil Bourne's death. I first encountered him as chair of ISMB 2000 in San Diego at my first ever computational biology conference. He always pushed for open science and always tried to make things better. In both he made a positive difference

news.virginia.edu/content/memo...

10.03.2026 20:20 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Crushed to hear of Mark Batzer’s passing. He was the Boyd Professor at Louisiana State University. His influential research revealed how mobile elements shape the genomes of humans & other mammals. Mark’s personality, generosity & positivity were larger than life. He lifted everyone up. HUGE loss πŸ’”

22.01.2026 17:38 πŸ‘ 12 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0
chart of child mortality in history, roughly 48% for all societies across the globe…until the 20th century, where it plummets to 4%

chart of child mortality in history, roughly 48% for all societies across the globe…until the 20th century, where it plummets to 4%

Currently dorking out over this graph about child mortality with my brother. Just mind boggling to take in.

02.12.2025 05:00 πŸ‘ 2489 πŸ” 971 πŸ’¬ 72 πŸ“Œ 161

Never a doubt 😁

14.11.2025 21:19 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Congratulations Zam! This is fantastic news!

14.11.2025 21:14 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

My lab at hiring! - we have TWO postdoc positions (one computational, one wet lab focussed) at Yale @yaleschoolofmed.bsky.social, working closely with our group members at University of Cambridge, UK @cambridgeuni.bsky.social

Please help to spread the word!

Adverts with full details below ⬇️

26.03.2025 15:31 πŸ‘ 25 πŸ” 31 πŸ’¬ 2 πŸ“Œ 1

Celebrating all of the amazing women in science I've had as mentors, role models, colleagues and friends πŸ§¬πŸ‘©β€πŸ’»πŸ§ͺ

12.02.2025 02:07 πŸ‘ 7 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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The Dictator's Handbook - Wikipedia

Not sure if this is exactly what you are looking for, but I found this book to be very enlightening en.m.wikipedia.org/wiki/The_Dic...

07.02.2025 21:02 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Congratulations Jill! That is fantastic news

16.01.2025 20:31 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

A phenomenal effort to bring this together with so many interesting aspects of how genetic background influences cancer development. I'm honoured to have been part of this project!

15.01.2025 19:51 πŸ‘ 5 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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Genetic background sets the trajectory of cancer evolution Human cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans,...

🌟NEW PREPRINT ALERT!🌟

We are very pleased to introduce #StrainDifferences: β€œGenetic background sets the trajectory of cancer evolution”

www.biorxiv.org/content/10.1...

🧡[1/12]

15.01.2025 19:19 πŸ‘ 83 πŸ” 26 πŸ’¬ 8 πŸ“Œ 5
Associate Professor / Professor of Evolutionary Genomics - Job Opportunities - University of Cambridge Associate Professor / Professor of Evolutionary Genomics in the Department of Genetics at the University of Cambridge.

Associate Professor / Professor of Evolutionary Genomics
www.jobs.cam.ac.uk/job/49389/

29.11.2024 11:19 πŸ‘ 67 πŸ” 76 πŸ’¬ 2 πŸ“Œ 1
Meeting topics and invited list of speakers

Meeting topics and invited list of speakers

Abstract submissions are still open for the CSHL Network Biology meeting in March 11 - 15 2025 (abstract deadline: Jan 10). A large fraction of talks will be selected from the abstracts. On behalf of the organizers, we look forward to welcoming you there.
meetings.cshl.edu/meetings.asp...

26.11.2024 13:16 πŸ‘ 16 πŸ” 7 πŸ’¬ 1 πŸ“Œ 0

Chicken chicken chicken

22.11.2024 00:41 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thanks. I'll check it out

14.11.2024 13:43 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Doesn’t seem to be. Many of the JGI authors on this paper have been working on understanding UCEs (with considerable success) at least since the 2007 Ahituv paper that knocked out some UCEs and got viable, apparently normal mice. Knocking out this element results in clear limb abnormalities

14.11.2024 02:12 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

I’ve just read this pre-print and it’s fantastic. A conserved element with no endogenous enhancer activity is nonetheless necessary and sufficient for extreme long range enhancer action. Recommend to anyone interested in gene regulation

13.11.2024 21:15 πŸ‘ 28 πŸ” 4 πŸ’¬ 1 πŸ“Œ 1

This looks like a great meeting! In a great place too

12.11.2024 11:15 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

The events of this week suggest that the excitement and hype around AI in science won’t be dying down anytime soon

09.10.2024 13:36 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

8/tl;dr: In most situations, it is to the author's maximal benefit to license their manuscripts thusly:

preprints: any CC license
journal publication: CC BY only

πŸ§ͺ #AcademicSky

05.10.2024 22:03 πŸ‘ 8 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0

Far from the Tree / Andrew Solomon
The Sports Gene / David Epstein
The Vaccine Race / Meredith Wadman

And others listed already

04.10.2024 21:28 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
The cover of a scientific comic titled "What's Wrong with this DNA?"

The cover of a scientific comic titled "What's Wrong with this DNA?"

The comic is part of the scientific outreach activities from the MRC Toxicology Unit in Cambridge and the home
@s-j-aitken.bsky.social's research group

25.04.2024 21:07 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Pervasive lesion segregation shapes cancer genome evolution - Nature Mutagenic lesions such as those that give rise to cancer frequently segregateβ€”unrepairedβ€”during cell division, resulting in phasing of multiple alleles across generations of daughter cells and co...

The story is based on the discovery of lesion segregation a few years ago (www.nature.com/articles/s41...), in a project that I played a part in, which is a great read too

25.04.2024 21:05 πŸ‘ 2 πŸ” 0 πŸ’¬ 2 πŸ“Œ 0
Whats wrong with this DNA? ENG - Google Drive

Celebrate #DNADay by reading the comic (and scientifically accurate πŸ§ͺ) adventures from Cell Town, home of Pol, Hely, Topy, and the Repair Squad as they set out on another round of cell division! drive.google.com/drive/folder...

25.04.2024 20:57 πŸ‘ 6 πŸ” 1 πŸ’¬ 2 πŸ“Œ 0

The use of the phrase β€œancestry-specific variant” is increasing, particularly to describe rare Single-nucleotide variants (SNVs). But these alleles are not ancestry-specific. They have not yet been found elsewhere, but they will be. 1/n

28.02.2024 13:44 πŸ‘ 30 πŸ” 11 πŸ’¬ 2 πŸ“Œ 0
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Improving whole genome sequence data analyses Christine Beck and Peter Audano are at the forefront of research involving long-read sequence data. They are particularly interested in structural variants, where segments of the genome are deleted, i...

At the forefront of research involving long-read sequence data, JAX's @christinebeck.bsky.social & Peter Audano discuss how adjustments to the technical and analytical infrastructure are needed. Read more in their recent Genome Research paper πŸ§ͺ🀝πŸ–₯️ 🧬 :
www.jax.org/news-and-ins...

22.02.2024 18:56 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0