Antoine Garnier-Crussard

Why do many folks lose weight with Parkinson’s disease? The biology is more complex than eating less. New paper in Movement Disorders how multiple biological pathways combine to drive weight loss in Parkinson’s disease.

Honored to share our work on #Parkinsons in the journal Movement Disorders!

In sporadic and genetic PD, patients with synuclein SAA+ PD have more striatal DAT deficit relative to atrophy while those with synuclein SAA- PD have more striatal atrophy relative to DAT deficit.

doi.org/10.1002/mds....

🚨 Publication
Our letter to the editor is published in Alzheimer's and Dementia DADM @alzdemjournals.bsky.social
A French qualitative study on GPs' perceptives on AD BBM !

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

The TREM2 agonistic antibody AL002 in early Alzheimer’s disease: a phase 2 randomized trial - Nature Medicine In this phase 2, randomized trial in early Alzheimer’s disease, the TREM2 agonistic antibody AL002 showed target engagement but did not meet the primary endpoint of change from baseline in Clinical De...

www.nature.com/articles/s41...

Cardiac amyloidosis and the risk of Alzheimer’s disease: a population-based nested case-control study Background Transthyretin amyloidosis cardiomyopathy (ATTR-CM) and Alzheimer’s disease (AD) are age-related disorders characterized by pathological protein aggregation. Despite shared risk factors and ...

www.medrxiv.org/content/10.6...

📢 New Preprint “Cardiac amyloidosis and the risk of Alzheimer’s disease: a population-based nested case–control study”, using the French National Health Data System #SNDS
N=96000
⚡individuals with ATTR-CM had a lower likelihood of AD aOR: 0.65, 99% CI: 0.56–0.75
🔗 lnkd.in/d7GGYNQH

In vivo-measured Lewy body pathology is associated with neuropsychiatric symptoms across the Alzheimer’s disease continuum - Molecular Psychiatry Molecular Psychiatry - In vivo-measured Lewy body pathology is associated with neuropsychiatric symptoms across the Alzheimer’s disease continuum

In vivo-measured Lewy body pathology is associated with neuropsychiatric symptoms across the Alzheimer's disease continuum
www.nature.com/articles/s41...

🚨 Paper Alert 🚨
💡If you are interested in the locus coeruleus and dementia with Lewy bodies, this systematic review, led by @sophiedautricourt.bsky.social 👏, is for you!

🔓 shorturl.at/b3ws2

@robindeflores.bsky.social @claireandre.bsky.social
@hcl-recherche.bsky.social @neuropresage.bsky.social

Late-onset dementia with leukoencephalopathy and a COL4A2 gene variant, causal link or fortuitous association: a case report Cerebral small vessel disease can manifest as vascular dementia, typically associated with vascular risk factors or cerebral amyloid angiopathy, and m…

🚨 I share this case report, describing a case of late-onset dementia, associated with a likely pathogenic COL4A2 variant

👉 Late-onset dementia with leukoencephalopathy and a COL4A2 gene variant, causal link or fortuitous association: a case report

www.sciencedirect.com/science/arti...

🧠 🚨 New publication in Scientific Reports !

👉 Heterogeneity of white matter hyperintensities in Alzheimer’s disease captured by multimodal neuroimaging

www.nature.com/articles/s41...

👉 We studied MRI (T1w, T2w) and PET (18F-florbetapir and 18F-FDG) signals within WMH in 142 older adults

🚨Postdoc position open at @BarcelonaBeta🚨
We're looking someone to work on a project at the intersection of cardiovascular and neurodegenerative research 🫀🧠
Fully funded position!!!
More details: www.imim.cat/media/upload...
Please share!
#Alzheimer's #ENDALZ

@teddynovais.bsky.social @hcl-recherche.bsky.social

🚨 Happy to share our commentary, on Sacubitril/Valsartan, Heart Failure and Risk of Dementia 🧠💊❤️
link.springer.com/article/10.1...

The original paper link.springer.com/article/10.1...

Our review in 2024 on this topic: alzres.biomedcentral.com/articles/10....

🆘Brain & Heart health are connected 🧠❤️

Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia This Delphi study aimed to reach international consensus on the diagnosis of cognitive impairment and dementia via a revision of the International Society for Vascular Behavioural and Cognitive Disord...

🚨VasCog-2🚨

👉 Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia—The VasCog-2-WSO Criteria 🧠🩸🧠

jamanetwork.com/journals/jam...

🚨 Paper Alert

Happy to share this review on intrinsic capacity (IC) in dementia with Lewy bodies 💪🧠

🔓 www.sciencedirect.com/science/arti...

🚨 VasCog 2025 🚨 👉 The conference of the International Society of Vascular Behavioural and Cognitive Disorders

🧠 Thrilled to participate in the upcoming #VASCOG2025 conference, where I will be delivering a talk on WMH in AD

💥 program online
lnkd.in/dhhaAytZ

@hcl-recherche.bsky.social

🧠🩺Comorbidities and comorbidity burden in patients with neurocognitive disorders

👉A detailed, in-depth study of comorbidities (individual comorbidities and comorbidity indices) in >3000 real-life patients seen in memory clinics💡

@hcl-recherche.bsky.social

link.springer.com/article/10.1...

⛲💦🚰
👉"In this cluster-randomized, crossover trial, hospital-wide use of lactated Ringer’s solution as compared with normal saline did not alter the incidence of death or hospital readmission within 90 days."

Crossroads in diagnosis of dementia in England: a perilous position The recent Care England exposed further tensions in English dementia policy as regards dementia diagnosis.

My Substack. open.substack.com/pub/shibley/...

🚨 VasCog 2025 🚨 👉 The conference of the International Society of Vascular Behavioural and Cognitive Disorders

🧠 Thrilled to participate in the upcoming #VASCOG2025 conference, where I will be delivering a talk on WMH in AD

💥 program online
lnkd.in/dhhaAytZ

@hcl-recherche.bsky.social

Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis Plasma phosphorylated tau (p-tau) biomarkers show promise to transform the clinical management of Alzheimer's disease by providing more accessible and…

🧠🩸Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

www.sciencedirect.com/science/arti...

🚨 Paper Alert

Happy to share this review on intrinsic capacity (IC) in dementia with Lewy bodies 💪🧠

🔓 www.sciencedirect.com/science/arti...

What evidence do we have on the Social Determinants of Dementia (SDOD)?

Delighted that this scoping review, a year or so in the making, is now published in @alzdemjournals.bsky.social. Expertly led by Anouk Geraets, we identified...

doi.org/10.1002/alz....

1/

A randomized trial (N>2,100 participants, multi-center) of structured vs self-guided lifestyle interventions in older adults shows the former improved cognitive function jamanetwork.com/journals/jam...

Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function This randomized clinical trial assesses the effect of structured vs self-guided multidomain lifestyle interventions on changes in global cognitive function over 2 years among older adults at risk of c...

🧠🎈Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function
The US POINTER RCT

👉The structured higher-intensity intervention had a greater benefit on global cognition than the self-guided low-intensity intervention.

jamanetwork.com/journals/jam...

Donanemab receives positive opinion from the Committee for Medicinal Products for Human Use (CHMP) in early symptomatic Alzheimer's disease | Eli Lilly and Company The Investor Relations website contains information about Eli Lilly and Company's business for stockholders, potential investors, and financial analysts.

Donanemab receives positive opinion from the Committee for Medicinal Products for Human Use (CHMP) in early symptomatic Alzheimer's disease

investor.lilly.com/news-release...

🚀 Étude publiée sur les facteurs associés à la prescription d'une prise en soins en orthophonie 🗣️💬 en consultation mémoire 🧠 à partir des données de 574 patient-es !
www.jle.com/fr/revues/gp...

📢 Preprint alert!
Check out the results of our international consensus effort which established research recommendations and identified high-priority future directions in the field of sleep, aging and dementia. Huge thank you to ISTAART and all collaborators for this tremendous team work ✨👇

Very happy to share our preprint on the associations between sleep disturbances and cholinergic PET imaging in older adults! 🧠 💤

👉 We found that higher REM sleep EEG slowing was associated with cholinergic denervation in older participants with and without MCI.

#REMsleep #cholinergicsystem

#rfmasa2025 #lausanne #alzheimer #diagnostic #avancées #démences… | Leenaards Memory Center | CHUV 🚀 Annonce Spéciale ! 𝗥𝗙𝗠𝗔𝗦𝗔𝟮𝟬𝟮𝟱 𝗘𝗽𝗶𝘀𝗼𝗱𝗲 𝟭 Nous sommes ravis de vous annoncer que Nicolas Villain sera l'un des orateurs vedettes du congrès #RFMASA2025 à #Lausanne ! 🗣️ Il traitera du grand déb...

www.linkedin.com/posts/centre...