Advances in genomics are giving exciting new perspectives on biology of speech, language & reading. My latest peer-reviewed paper is a tutorial, guiding readers from different backgrounds through the history of the field, current state-of-the-art, & where weโre heading. A taster in this thread.๐งช
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They understood how the immune system is kept in check
Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi are awarded the Nobel Prize in Physiology or Medicine 2025 for their groundbreaking discoveries concerning peripheral immune tolerance
www.nobelprize.org/prizes/medic...
Technological advances typically punctuate accelerated discovery in biomedical science, and the past decade has been exemplary regarding breakthroughs in our genomic understanding of human biology in health and disease
x.com/NatureRevGen...
The Myth of the Designer Baby
A genomics firm saying they can help parents with โgenetic optimizationโ of their embryos is tone-deaf Silicon Valley marketing trampling over legitimate science. Parents should be wary. www.scientificamerican.com/article/why-... (h/t @justincaouette.bsky.social)
Biobank-scale genomic research projects from around the globe
www.the-innovation.org/article/doi/...
Among 27 NBSeq programs, only 74 (1.7%) genes included by over 80% of programs. Substantial variability in gene selection across programs exists, highlighting the need for a systematic approach to prioritize genes.
www.gimjournal.org/article/S109...
When science fiction becomes science fact: in a triumph of science based personalized therapy a baby with a unique fatal #genetic disease was saved by a bespoke #CRISPR approach. Unthinkable 20 years ago. www.nature.com/articles/d41...
An atlas of tissue-specific protein-protein associations helps to prioritise targets for drug discovery
www.ppiatlas.com?ref=blog.ope...
Computer scientists and bioinformaticians address four key questions to help rookie coders to make the right choice
https://go.nature.com/42UuoT3
Implicates 700 effector genes and highlight eight biological processes including the circadian clock, glial-cell-related processes and pathways with an established role in osteoarthritis (TGFฮฒ, FGF, WNT, BMP and retinoic acid signalling, and extracellular matrix organization)
Scientists have developed CIPDEL, a new GENE EDITING method using Cas12aโs unique DNA-cutting ability to enhance gene editing precision. New dawn to safer medical therapies, improved crops, and more efficient research tools. doi.org/10.1186/s130...
Cepheid and Oxford Nanopore collaboration to look into infectious disease first
nanoporetech.com/news/cepheid...
A great study where monogenic and polygenic studies converges
Amazing to learn how DNA match led to the true culprit
Back in 1962, DNA circles were first spotted in cancer cells. Now, armed with modern molecular biology and genomics tools, researchers are realising that these circles might explain why some cancers are more lethal than others.
#ChemSky
Today for the first time in decades, a new oral antibiotic to treat urinary tract infections was approved by the FDA
Gepotidacin is a triazaacenaphthylene that inhibits bacterial DNA replication by targeting DNA gyrase and topoisomerase IV
Trade name? BLUJEPAยฎ !!!
www.gsk.com/en-gb/media/...
For the first time, researchers have used the CRISPR gene editor to repair AAT gene in the human body.
www.science.org/content/arti...
Lungfish has 30 times as much DNA as humans
Computational biology XKCD!
One of those truly multiomic studies. Get to see sQTL, eQTL, pQTL, mQTL connect genetic etiology across molecular traits and health outcomes
Congrats. As someone all ready to get a MK1D for AMR work, may i ask how is your exp working with MK1D for microbe study
RNA xkcd.com/3056
Synthetic biologists discuss with Nature why itโs so hard to write a genome. โWe underestimated how complex biology is.โ ๐งช ๐งฌ
SBX technology utilizes a proprietary biochemical conversion process to expand and encode the sequence of a DNA template into an Xpandomer molecule.
The image showcases three separate podcast advertisement banners placed vertically. Each banner contains artwork on the left and text on the right. The top banner features a digital illustration of a double helix with scientific imagery and human figures on a teal background. The text reads "Variant Effect What?" for a podcast released on May 16. The middle banner, on a red background, depicts a circular illustration with intricate biological designs and a central glowing orb. The text states "Melanoma And Variant Effects: beyond sunscreen," dated June 6. The bottom banner, set on a teal background, presents another double helix with molecular designs. The text says "Your genes on drugs: context matters!" released on September 20.
#RareDiseaseDay (coming up on Friday, February 28, 2025) is a day dedicated to raise awareness of rare diseases and the people they affect. Tune in to this amazing podcast series that delves into the science behind mapping variants in diseases and rare diseases. www.varianteffect.org/podcast
Simultaneous single-cell CRISPR, RNA, and ATAC-seq enables multiomic CRISPR screens to identify gene regulatory relationships
www.biorxiv.org/content/10.1...
CZI is partnering with an initial cohort of experts in the single-cell field and developers of lifescieence tech. This partnership prioritizes data generation with initial data sets including organisms such as mouse, zebrafish, and primary human cell models.
www.prnewswire.com/news-release...
Graphical abstract of BioChatter
Applying LLMs to biomedical research today can go one of two ways: we either use a closed-source web app, or we get coding ourselves. Many researchers lack training for the latter, so their only choice is the former. We want to change that. www.nature.com/articles/s41...
Check out my recent talk on dimensionality reduction, where I try to lay out my thoughts on the topic: youtu.be/AuJzMnH78wM?...
Truly speaking meeting Nobel Laureate Paul Nurse back in 2001 over a lecture inspired me to learn more about DNA and Genetics and Genomics...
