We’ve mapped the Achilles tendon at single-cell resolution 🧬 — revealing 6 fibroblast types with distinct roles across muscle–tendon zones. A new atlas for understanding injury + repair.
Find our more in our new preprint www.biorxiv.org/content/10.1...
#Tendon #CellAtlas #SpatialTranscriptomics
M. V. Franchi et al. offer this #TranslationalPerspective highlighting new insights into acute tendon molecular reprogramming after rupture based on research by Mimpen et al. (2025)✍️
🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Congratulations! Wishing you & your little ones all the very best! ✨
My condolences. Sending you all much love and strength.
Link to our paper "Exploring cellular changes in ruptured human quadriceps tendons at single-cell resolution":
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Finally, a big thank you to Asst Prof @mvfranchi.bsky.social, Dr Christopher Fry, and Prof Michael Kjaer for writing this wonderful piece highlighting our work!
This study was a big team effort as part of the @cziscience.bsky.social-funded "Tendon Seed Network" led by @sarahsnelling.bsky.social, Dr Mathew Baldwin, @adamcribbs.bsky.social & many others @ndorms.bsky.social.
All the data can be viewed & downloaded:
cellxgene.cziscience.com/collections/...
This Graphical abstract depicts healthy and acutely ruptured human quadriceps tendons. Using single nucleus RNA sequencing, the analysis shows that stromal cells change in ruptured quadriceps tendons, including increase of activated phenotype of fibroblasts, vascular endothelial cells, and macrophages, as well as increase in cell-cell interactions between fibroblasts and vascular endothelial cells.
The transcriptomics analysis of our paper "Exploring cellular changes in ruptured human quadriceps tendons at single-cell resolution" suggests that fibroblasts and endothelial cells are key orchestrators of the early injury response within ruptured quadriceps tendon.
Very excited to see this Translational Perspective by Asst Prof @mvfranchi.bsky.social, Dr Christopher Fry, and Prof Michael Kjaer discussing our recent transcriptomics study on the early injury response in human quadriceps tendons in @jphysiol.bsky.social.
Congratulations! 👏🏻
Happy New Year! Could you add me as well, please?
If you're interested in the extracellular matrix of soft tissues and the role ECM plays in osteoarthritis then this systematic review is for you!
boneandjoint.org.uk/Article/10.1...
Interested? Do take a look at Supplementary Tables i and ii!
These tables provide an overview of the data on ECM features by tissue type in humans (Table i) and animal models of OA (Table ii), including the direction of change in OA, measurement method, and references.
It is great to finally share our systematic review on structural extracellular matrix components in soft tissues in osteoarthritis!
Congratulations to my co-authors Iwan Raza and @sarahsnelling.bsky.social.
boneandjoint.org.uk/Article/10.1...
Wonder what it is like to study at @ndorms.bsky.social at the University of Oxford? Here we share some of our experiences from working in an interdisciplinary team with the wonderful @sarahsnelling.bsky.social.
Please feel free to get in touch if you have any questions!
