Sarah Gallois-Montbrun

Thanks to all the team Marjory Palaric, Margaux Versapuech, @delphinej.bsky.social, @corentinaube.bsky.social , @sarahgalloism.bsky.social
and collaborators Jacques Dutrieux, Jean-Christophe Paillart, the proteom'ic plateform
@institutcochin.bsky.social
@inserm.fr
@cnrs.fr
@upcite.bsky.social

Excited to share our new publication about how GABARAP #autophagy proteins regulate #HIV genomic RNA packaging.
Link to the article ⬇️
doi.org/10.1038/s443...
Thank you to @anrs-mie.bsky.social, @sidaction.bsky.social @frm-officiel.bsky.social for supporting our work.
@institutcochin.bsky.social

Clarisse Berlioz-Torrent @cberlioztorrent.bsky.social @institutcochin.bsky.social @upcite.bsky.social and co-workers @unistra.fr report that GABARAP #autophagy proteins regulate the packaging of #HIV-1 genomic RNA into infectious #virions. #virology

-> www.embopress.org/doi/full/10....

I am so proud of @jezcarlton.bsky.social . What a magnificent inaugural lecture, many congratulations Professor Carlton!

schematic showing MX1 mode of action

transiently associates with them, and induces their retrograde transport via dynein and the microtubule network toward a perinuclear region near the microtubule-organizing center (MTOC), where the vRNPs remain sequestered.

Contrary to previous assumptions, we show in this study that the human restriction factor MX1 most potently inhibits human influenza A viruses during the late stages of replication. MX1 appears to sense trafficking viral ribonucleoproteins (vRNPs) en route to the plasma membrane,

Human MX1 orchestrates the cytoplasmic sequestration of neosynthesized influenza A virus vRNPs | PNAS Interferon-inducible Myxovirus resistance 1 (MX1) proteins are known to restrict influenza A virus (IAV) transcription/replication process. Herein,...

After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉
www.pnas.org/doi/10.1073/...

Pleased to announce launching Institut Cochin Foundation, on Sept. 18 at 6 p.m., upon registration, either in the Rosalind Franklin room, 22 rue Méchain, Paris or via video conference: presentation of @institutcochin.bsky.social, meet researchers and call for donations-thanks for your support!

🎊🎉🎊🎉🎊🎉🎊🎉🎊🎉
Pleased to announce the start of the Institut Cochin Foundation !

On September 18th at 6 p.m., upon registration come or connect to learn about the fantastic research done at the Institut Cochin @institutcochin.bsky.social , meet the people that do it and call for donations!

Thanks to our funding bodies: @anrs-mie.bsky.social @sidaction.bsky.social @frm-officiel.bsky.social and to all co-authors @sarahgalloism.bsky.social @matkovic.bsky.social
@melissa-aitsaid.bsky.social @cberlioztorrent.bsky.social @fmargottin.bsky.social

🦠🦠🦠New paper out in JBC! Argonaute 1 contributes to HIV-1 transcriptional silencing. doi.org/10.1016/j.jb...
Collaboration between the Host-Virus Interaction & Rétrovirus, infection & latency teams @institutcochin.bsky.social @inserm.fr @cnrs.fr @upcite.bsky.social ⬇️

EXCLUSIF. L'appel des trois grands instituts de recherche français : "Trump ne cible pas la science par hasard" Trois de nos plus grands scientifiques, Yasmine Belkaid, Bana Jabri et Alain Puisieux, prennent la parole pour appeler à des réponses courageuses des pouvoirs publics face aux attaques contre la recherche, aux Etats-Unis, mais aussi de ce côté de l’Atlantique.

🔴 EXCLUSIF. L'appel des trois grands instituts de recherche français : "Trump ne cible pas la science par hasard" ⬇️

✍️ @stephaniebenz.bsky.social, @ericchol.bsky.social et Thomas Mahler

Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations Tenthorey et al. compare the effects of missense and indel mutations on the acquisition of functional novelty by the rapidly evolving antiviral protein TRIM5α. They find that single indel mutations al...

Proud of this work, led by the amazing Jeannette Tenthorey (now Assistant Professor at UCSF), demonstrating the adaptive power of single indel mutations in host-virus arms races, but a little sad that this is the coda to her amazing postdoc in the Malik & Emerman labs.

www.cell.com/cell-genomic...

Dans une étude publiée dans la revue Nature Communications, des scientifiques révèlent l’existence de nouveaux antigènes produits à partir du génome du virus et capables de générer de puissantes réponses immunitaires. Cette découverte élargit les cibles potentielles des vaccins contre le VIH et pourrait ouvrir la voie à de nouvelles stratégies thérapeutiques. Image d'illustration. © AdobeStock - Corona Borealis

👩‍⚕️👨‍⚕️ VIH-1 : le génome du virus produit plus d’antigènes qu’on ne le pensait.
Cette découverte élargit les cibles potentielles des vaccins contre le VIH et pourrait ouvrir la voie à de nouvelles stratégies thérapeutiques.

▶ www.insb.cnrs.fr/fr/cnrsinfo/...

La science est un bien commun !

Stand up for Science!

Image de la foule occupant la place port royal

Image de la foule occupant la place port royal

Image de la foule occupant la place port royal

Image de la foule occupant la place port royal

Encore bravo pour cette mobilisation. Le combat pour les libertés académiques continue.

@sufs-paris-rp.bsky.social #StandUpForScience felt really good to walk the streets of Paris for a couple of hours in support of science. We were thousands!

#StandUpForScience2025 #StandUpForScience #Paris

PUBLIC RESEARCH!! ✊🧪 @standupforscifr.bsky.social @sufs-paris-rp.bsky.social @standupforscience.bsky.social

#Communiqué 🗞️ Le CNRS exprime sa solidarité avec les scientifiques exerçant aux États-Unis, où la liberté académique est aujourd'hui mise à l’épreuve.

👉 www.cnrs.fr/fr/presse/le...

#science #virology

Unveiling conserved HIV-1 open reading frames encoding T cell antigens using ribosome profiling - Nature Communications Here, using ribosomal profiling, the authors characterize the translatome of HIV-1 revealing tens of alternative open reading frames (ARF) that encode conserved viral antigens and show that ARF-derive...

I am very pleased to share with you this fantastic work done in in collaboration with Arnaud Moris’steam. It has been a very pleasant collaboration and a fantastic project done at the #I2BC. #microproteine #riboseq #HIV www.nature.com/articles/s41...

Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...

Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin?
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇

🧪Excited to host a webinar on RNA-binding proteins and their pivotal role in viral pathogenesis and immune defense 🦠
🗓️Friday, Feb 14th at 11:00 AM (Paris Time)
Great speakers: Alfredo Castello, Yara Bouery and Sébastien Pfeffer.
Register here: sondage.app.u-paris.fr/954299 or using the QR code

Job alert! post-doctoral position on #macrophages biology to study the role of a post-translational modification in inflammation and ROS production with Tarik Issad's team @institutcochin.bsky.social in #Paris! Please apply on the @cnrs.bsky.social website: emploi.cnrs.fr/Offres/CDD/U...

Fresh out of the press! ✨Check out our new paper on the violent entry of the HIV capsid into the nuclear pore — and how it cracks the gate! 🤯 💥 Incredible work from @becklab.bsky.social and @hummerlab.bsky.social 🤩 More here: www.biophys.mpg.de/2842024/hivcapsid-cracks-the-npc?c=2011019 🔗 #teamTOMO

Receptor-binding proteins from animal viruses are broadly compatible with human cell entry factors - Nature Microbiology Functional systematic pseudotype virus-based analysis of the ability of diverse animal viruses to enter into a panel of well-characterized human cell lines shows a broad compatibility between animal v...

To get 2025 off to a good start, I'm delighted to share with you our study published today in @naturemicrobiol.bsky.social 🎉 We studied the ability of the receptor-binding proteins (RBP) of >100 animal viruses to mediate entry into human cells. A short thread below.
www.nature.com/articles/s41...

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.

Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this!

So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!

www.cell.com/molecular-ce...