Clarisse Berlioz-Torrent

Evolutionary characterization of antiviral SAMD9/9L across kingdoms supports ancient convergence and lineage-specific adaptations - Nature Ecology & Evolution A search for analogues of the human SAMD9/9L antiviral genes identifies convergent evolution of this gene family in the bacterial and animal kingdoms, with species-specific and recent genomic signatur...

📖Latest from the lab:
Evo. characterization #antiviral #SAMD9/9L across #kingdoms🚶‍♀️🦍🦠🧫🖥️: ancient #convergence + #adaptations @natecoevo.nature.com

Led by amazing Alexandre Legrand +major contributions by Rémi Demeure & Amandine Chantharath @ciri-lyon.bsky.social 1/n

www.nature.com/articles/s41...

Thanks to all the team Marjory Palaric, Margaux Versapuech, @delphinej.bsky.social, @corentinaube.bsky.social , @sarahgalloism.bsky.social
and collaborators Jacques Dutrieux, Jean-Christophe Paillart, the proteom'ic plateform
@institutcochin.bsky.social
@inserm.fr
@cnrs.fr
@upcite.bsky.social

Excited to share our new publication about how GABARAP #autophagy proteins regulate #HIV genomic RNA packaging.
Link to the article ⬇️
doi.org/10.1038/s443...
Thank you to @anrs-mie.bsky.social, @sidaction.bsky.social @frm-officiel.bsky.social for supporting our work.
@institutcochin.bsky.social

🧪Very happy to share our latest research in
@emboreports.org

Thank you to all the team and collaborators, and to
@anrs-mie.bsky.social @sidaction.bsky.social @frm-officiel.bsky.social for funding.
@institutcochin.bsky.social
@inserm.fr
@cnrs.fr
@upcite.bsky.social

#HIV #autophagy #RNA #virus

GABARAP proteins regulate the packaging of HIV-1 genomic RNA into virions | EMBO reports imageimageGABARAP autophagy proteins are co-opted by HIV-1 to promote selective viral genomic RNA packaging and production of infectious virions. Proteomics and validation experiments show that LC3/G...

🧪Very happy to share our latest research in
@emboreports.org
Thank you to all the team and collaborators, and to
@anrs-mie.bsky.social @sidaction.bsky.social
@frm-officiel.bsky.social for funding.

@institutcochin.bsky.social @inserm.fr @cnrs.fr @upcite.bsky.social
#HIV #autophagy #RNA #virus

Pleased to announce launching Institut Cochin Foundation, on Sept. 18 at 6 p.m., upon registration, either in the Rosalind Franklin room, 22 rue Méchain, Paris or via video conference: presentation of @institutcochin.bsky.social, meet researchers and call for donations-thanks for your support!

🎊🎉🎊🎉🎊🎉🎊🎉🎊🎉
Pleased to announce the start of the Institut Cochin Foundation !

On September 18th at 6 p.m., upon registration come or connect to learn about the fantastic research done at the Institut Cochin @institutcochin.bsky.social , meet the people that do it and call for donations!

🦠🦠🦠New paper out in JBC! Argonaute 1 contributes to HIV-1 transcriptional silencing. doi.org/10.1016/j.jb...
Collaboration between the Host-Virus Interaction & Rétrovirus, infection & latency teams @institutcochin.bsky.social @inserm.fr @cnrs.fr @upcite.bsky.social ⬇️

ESCRTing membrane remodelling and repair Teaser: My group is interested in understanding the mechanisms that govern functional specificity within the Endosomal Sorting Complex Required for Transport (ESCRT) pathway, a cellular machinery that...

Seminar @institutcochin.bsky.social on April 3 at 14:30 by Monica Agromayor (King 's College, London): ESCRTing membrane remodelling and repair
institutcochin.fr/en/agenda/es...
@cnrs-idf-villejuif.bsky.social @cnrsbiologie.bsky.social @inserm.fr @upcite.bsky.social

#FluorescenceFriday by Julie IMAG'IC and @delphinej.bsky.social from the @cberlioztorrent.bsky.social team. What could be better than #ExM coupled with a spinning microscope to study immune and virological #synapses ?
T cell (Actin ExM⚪from CHROMETRA) and B cell (Actin ExM ⚪+ CFSE 🟢)

@institutcochin.bsky.social is opening a position for a scientist wishing to establish his/her independent team. Application deadline 21/01/2025. For details and application:
institutcochin.fr/en/node/24264

Seminar on January 9 at noon given by 2 researchers recruited at Inserm in 2024:
Luca Simula: Targeting metabolism to improve intratumoral CAR T cell motility
Delphine Judith: NanoVesicles: the ins and outs of the immune and virological synapses
institutcochin.fr/en/agenda/fi...

KH and di-KH domains are generally recognized as RNA binding domains. However, the most ex-diKH of KHNYN lacks any detectable RNA-binding activity. Despite this it is required for ZAP-mediated antiviral activity.

Structural and functional characterization of the KHNYN extended-diKH domain for mediating ZAP antiviral activity Zinc finger antiviral protein (ZAP) binds CpG dinucleotides in viral RNA and targets them for decay. ZAP interacts with several cofactors to form the ZAP antiviral system, including KHNYN, a multidoma...

A preprint for Xmas
KHNYN is an essential endoribonuclease for the antiviral protein ZAP which targets RNAs with clustered CpG
Dinucleotides. We performed some structural characterization of the N-terminal extended di-KH domain of KHNYN and its close relative N4BP1.
www.biorxiv.org/content/10.1...

@institutcochin.bsky.social is opening a position for a scientist wishing to establish his/her independent team. Application deadline 21/01/2025. For details and application:
institutcochin.fr/en/node/24264

Hello @nature.com @cp-cell.bsky.social @cp-cellmetabolism.bsky.social @cp-cellreports.bsky.social

Nice to see you here 👋

#worldAIDSday: Institut Cochin is a pioneering research centre in #HIV research. In 2024 we are delighted to have a new tenured researcher: Delphine Judith, who was recruited at Inserm in the Virus-Host Interaction team. She seeks to understand how HIV-1 overcomes host barriers to spread in the body

Antibody-mediated mechanisms that correlate with malaria protection The receptor-binding domain, region II, of the Plasmodium vivax Duffy binding protein (PvDBPII), which binds the Duffy antigen receptor (DARC) during reticulocyte invasion by P. vivax is a leading blo...

Seminar at Institut Cochin on December 12 at noon by Francisco Jose MARTINEZ BLAZQUEZ (Biologie de Plasmodium et Vaccins, @pasteur.fr): Antibody-mediated mechanisms that correlate with malaria protection.
institutcochin.fr/en/agenda/an...

Here is a brief summary of academic journals and news account.

Please help me add more accounts to this list!

go.bsky.app/hCfhqn

L'Institut Cochin, centre de recherche biomédicale, rejoint Bluesky. 34 équipes et 10 plateformes (mandat 2025-2029) mènent une activité de recherche fondamentale et translationnelle autour de 5 axes : cancer, immunologie, endocrinologie-métabolisme, microbiologie, plasticité cellulaire-reproduction

Post-doc opportunity! 📣📣📣 Our host-virus interaction lab (Institut Cochin, France) is seeking a highly motivated post doctoral researcher for a 2-year position to work on HIV latency. Join us in exploring cutting-edge molecular mechanisms in the beautiful city of Paris!

📣📣📣
Come join us and set up your team in the I2BC Cell Bio Dept!

You will find great science, diverse topics and models, spacious labs, supportive environment, and fun colleagues. We are a short (train) ride south of Paris.

Please DM me with any questions and help us spread the word 🙏

Look who's here
@pnas.org ✔️
@science.org ✔️
@naturecellbiology.bsky.social ✔️
@natrevgenet.bsky.social ✔️
@naturebiotech.bsky.social ✔️
@naturemicrobiol.bsky.social ✔️
@naturechemistry.bsky.social ✔️
@genesdev.bsky.social ✔️
@cellchembiol.bsky.social ✔️
@genomeresearch.bsky.social ✔️
@jcellbiol.bsky.social ✔️

Can I join too ? Thanks

Please include me, thanks

This contains the text of the detailed ad

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We're hiring a Group Leader in Infection Biology! 🧬
Apply now to join us at the IRIM in Montpellier, and lead cutting-edge research in pathogen virulence, host-pathogen interactions or drug resistance, and shape the future of infection biology! 🦠🧫
Please RT (and follow us!)
🗓️ Deadline: Feb. 28, 2025

📢 great opportunity to share your work on #autophagy during the 12th scientific days on autophagy (CFATG meeting), march 2025, on the french riviera (near Nice).
🔔 Abstract submission and early bird deadline: December 02, 2024. More information: www.atoutcom.com/autophagy/

Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib

Couldn’t find a virology starter pack so here’s one to get the ball rolling. Repost/reply if you are a virologist so I can find and add you to the list!

go.bsky.app/SinqoJU