🔬 I’m happy to share our new preprint on bioRxiv, where we introduce connectoids — a human stem cell–based, compartmentalized model to reconstruct the nigrostriatal pathway in vitro.
📄 Read more here: www.researchgate.net/publication/...
Out now in Stem Cell Reports! ✨
In this work we present a 3D co-culture system for the generation of human somatostatin (SST) interneurons 🧠
📄 Read the full paper here:
www.cell.com/stem-cell-re...
🚀 New preprint alert!
We developed a workflow to isolate nuclei from human stem cell-derived grafts in the rat brain for single-nucleus RNA-seq. This approach helps uncover how transplanted progenitors develop into mature neurons in vivo 🌟
Check it out here: www.biorxiv.org/content/10.1...
Exciting news in Huntington’s disease research! Transplanted human striatal progenitors can functionally integrate and modulate host brain circuits in a Huntington’s disease animal model - a promising step toward cell based therapy!
Full story: lnkd.in/dzgNb3-R
6 months ago I defended my PhD thesis, and looking back it feels both close and far away - so much has happened since then! Thanks to everyone who shared this journey with me, especially my supervisors Malin, Alessandro and Daniella, and also my opponent Gonçalo.
Onwards!
How can ventral midbrain #organoid derived from human pluripotent stem cells help to understand the #dopaminergic system and its pathologies?
@fiorenzano.bsky.social and collaborators review recent advances, remaining challenges, and emerging opportunities
www.embopress.org/doi/full/10....
