Guillermo Moreno-Alcántar

Palladium(II) Complexes with Noncovalent Interactions with DNA: Solution Speciation Controlled by Solvent Identity, pH, and Concentration The coordination capacity of thiosemicarbazone ligands and their synergism with palladium(II) ions modulate their reactivity, allowing custom design. Using thiosemicarbazones with two potential stable...

Read our last open access publication with @medbioinorgchem.bsky.social @gmalcantar.bsky.social thanks to @costactionnectar.bsky.social doi.org/10.1021/acs....

Congratulations, totally deserved!! 👏 🎉

A Small Molecule Drug-Based Ru(II) Polypyridine Mass-Tag for Multimodal Imaging of Tissue Samples Mass spectrometry imaging (MSI) is a powerful tool for spatially resolved multiomics analysis of tissue samples in clinical research. However, its proteomics application is still limited due to challe...

A Small Molecule Drug-Based Ru(II) Polypyridine Mass-Tag for Multimodal Imaging of Tissue Samples | ACS Central Science pubs.acs.org/doi/10.1021/...

Thanks Mathias!!

Looking forward to starting my independent research journey at
@cicbiomagune.bsky.social. we are going to develope new applications of #metallacages and #supramolecular #assemblies in biological systems! Exciting times are coming! Check back soon for PhD openings!

Very happy to share our team's work on the post-assembly modification of Pt(II) #metallacages. It wasn't easy, but I think this is a stepping stone for the development of real-world applications of metallacages. I hope you like it and stay tuned for the journal version!!

It has been great to present in the historical amphitheatre of the École nationale supérieure de chimie de Paris at the @isbomc25.bsky.social, we had a great evening with wonderful speakers and a great community! It is great being here!

Spotlight on Mechanosterics: A Bulky Macrocycle Promotes Functional Group Reactivity in a [2]Rotaxane Macrocycles typically hinder the reactivity of adjacent functional groups in mechanically interlocked molecules due to steric shielding. Herein, we report a [2]rotaxane in which a bulky macrocycle in ...

Thrilled to share our new @J_A_C_S paper: A bulky macrocycle enhances (not hinders!) functional group reactivity in a [2]‑rotaxane. Including definition and rationalization of this positive mechanosteric effect.
📖 pubs.acs.org/doi/10.1021/...
#Rotaxanes #JACS

Felicidades Miguel!

A packed house this morning at the #MMM2025 Organometallic Chemistry Summer School! Inspiring talks by A. Doyle and K. Engle, alongside impressive flash presentations from exceptionally talented PhD students.

Design of porous self-assembled homoleptic and heteroleptic Pd2+ cages incorporating silicon-based fluoride acceptors: the way towards nuclear imaging applications Supramolecular self-assembly is a promising tool to develop multifunctional theranostic agents and has recently entered the field of radiochemistry. In this work, lantern-shaped [Pd2L4]4+ metallacages...

Check out our latest study on Pd-cages for dual-modality imaging including cool MS analysis and fancy in ovo PET imaging, doi.org/10.1039/D5QI...
Congrats to Marike Drexler, Luisa Ronga, Ioannis Kanavos, @gmalcantar.bsky.social Daniela Kraus @timwitney.bsky.social! EIC Pathfinder #SMARTdrugs

Marike's shiny new paper is out!! she's a PhD student of @medbioinorgchem.bsky.social. Her work about the incorporation of fluorine radiopharmaceuticals within metallacages is now available in @inorgchemfront.rsc.org. Congrats to all the authors! @timwitney.bsky.social
pubs.rsc.org/en/content/a...

Biopharma dives into tumor-seeking radioactive drugs Nature Biotechnology - Big pharma and investors are piling into the precision radiation space as the next generation of increasingly potent targeted α-particle therapies promises to destroy...

Extremely honoured to have our work on supramolecular radiopharmaceuticals highlighted in the latest news in Nature Biotechnology!!! Thank you to the EIC Pathfinder SMARTdrugs @timwitney.bsky.social @hollandlab.bsky.social Alex Poot (UMCU) @cicbiogune.bsky.social Jordi Llop ! rdcu.be/emCW6

Harnessing Organometallic Gold(III) Complexes as Precision Scaffolds for Next‐Generation Therapeutic and Imaging Agents Gold(III) organometallic complexes, particularly cyclometalated Au(III) compounds, have emerged as powerful tools in catalysis and bioinorganic chemistry, offering unique reactivity distinct from the...

Our new paper is out in #chembiochem!
Even more special because it was coauthored with my longtime friend and collaborator @sophierthomas.bsky.social
Always a pleasure to turn shared ideas into shared results ❤️
🔗 doi.org/10.1002/cbic...

No, it's not the conclave, it is the opening of the #BBPore2025 at the UV historical campus. Looking forward to great science and biomedical applications of porous materials. Thanks to the local organizers @gminguezesp.bsky.social @gimenez-marques.bsky.social for the great organization.

Gold metallacages: Design principles and applications The synthesis of gold metallacages is raising interest and overcoming challenges in the construction of the systems, revealing exciting properties with potential applications in diverse fields. This review analyzes the advances and perspectives of this emerging family of assemblies.

Online now: Gold metallacages: Design principles and applications

Gold metallacages: Design principles and applications Metallacages (MCgs) are three-dimensional (3D)-supramolecular coordination complexes (SCCs) obtained by the self-assembly of metal ions with donor lig…

Our new paper is here!! "Gold #metallacages: Design principles and applications". With the contribution of @sophierthomas.bsky.social, Nina Willnhammer and @medbioinorgchem.bsky.social. Check it out #Openaccess in @cp-chem.bsky.social. www.sciencedirect.com/science/arti... enjoy the read!! @tum.de

Last paper of the year 2024, this time on gold compounds as anti-Leishmania agents!!! Thanks to all coauthors for the great work! www.sciencedirect.com/science/arti...