Jeff Downey

As always, it was a massive collaborative effort. Thanks to @filswirski.bsky.social, all the co-authors and the whole team at @mountsinaicvri.bsky.social

for the decline in cardiac function. Fortunately, either through genetic or transcriptional targeting of the type I interferon receptor (IFNAR1), we could attenuate this cardiac damage and conserve heart function, giving hope for future clinical interventions. Please give it a read!

This occurs after influenza seeds the heart by exploiting an atypical, trafficking pro-DC3 conduit, allowing it to access and replicate in cardiomyocytes. Unexpectedly, due to its indispensable antiviral function in the lung, type I interferon signaling on cardiomyocytes was directly responsible

Happy to share our latest work out now in Immunity @cp-immunity.bsky.social. doi.org/10.1016/j.im.... We provide insight into how influenza infections detrimentally impact cardiovascular health. Building on clinical observations, we show that influenza damages the heart and lowers its function.

As always, it was a massive collaborative effort. Thanks to @filswirski.bsky.social, all the co-authors and the whole team at @mountsinaicvri.bsky.social

for the decline in cardiac function. Fortunately, either through genetic or transcriptional targeting of the type I interferon receptor (IFNAR1), we could attenuate this cardiac damage and conserve function, giving hope for future clinical interventions. Please give it a read!

This occurs after influenza seeds the heart by exploiting a trafficking atypical pro-DC3 conduit, allowing it to access and replicate in cardiomyocytes. Unexpectedly, due to its indispensable antiviral function in the lung, type I interferon signaling on cardiomyocytes was directly responsible

#WeekendRead! #InterferonFriendOrFoe? @jeffdowney11.bsky.social @filswirski.bsky.social &co show @cp-immunity.bsky.social that upon severe flu lung infection, IAV is transported to the heart by DCs, where it infects cardiomyocytes to drive IFN-I, causing cardiac dysfunction! doi.org/10.1016/j.im...

Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart @cp-immunity.bsky.social
www.cell.com/immunity/ful... @jeffdowney11.bsky.social @filswirski.bsky.social

We are proud to announce that five CVRI faculty members - Fil Swirski (@filswirski.bsky.social), Mandy van Leent, Cameron McAlpine (@mcalpinelab.bsky.social), Maria Noval, and Sikander Hayat - will be presenting their groundbreaking work at Atherosclerosis GRC this Friday, June 27th.

Canadian Excellence Research Chair (CERC) in Human Immunology Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Are you an established PI that studies the human immune system and looking for a change of location? If the answer is yes, #McGill has an amazing opportunity to provide long-term funding at a world class institution. Apply now!!!! Please repost!!! mcgill.wd3.myworkdayjobs.com/en-US/McGill...

PBEEE/Quebec Merit Scholarship for Foreign Postdocs and Visiting Research Student and Visiting Researchers **Note that the FRQ is in the process of revamping their webpages. We will update links soon as we can with the current 2025 year's information. Be sure to check back to see if any eligibility or docu...

Are you a recent PhD (or soon to be PhD) from outside Canada looking to do a postdoc in Quebec?

Get in touch if you are excited about microbes, evolution, ecology, genomics (or all of the above!) and I'd be happy to help develop a project together!

www.mcgill.ca/gps/funding/...

Assistant Professor (Research), Department of Microbiology & Immunology, (C2-240724) Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Do you study host-pathogen interactions and want to start your own research program in a beautiful Canadian city with European flare? Look no further and join us at #McgillUniversity

Apply here!!👇🏼

mcgill.wd3.myworkdayjobs.com/McGill_Caree...

absolutely devastating — i feel incredibly grateful to have had you as a coach and you will be missed dearly, Sasha 🤍

My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. I hope people will find it useful.

It’s available on Amazon: tinyurl.com/mx2hewen

very excited to share the last chunk of my PhD work, now available on @biorxivpreprint.bsky.social! in this work, we explore how cis-regulatory variation and gene-environment (GxE) interactions influence immune response diversity directly in a cohort of hospitalized COVID-19 patients 1/n