jake

New VCP/p97 review article. Report on the excellent VCP meeting at CalTech last year and great overview on VCP and VCP disease.
doi.org/10.1016/j.nb...

Thrilled to be hosting Brenda Schulman, @aakritijain.bsky.social, @crismayorruiz.bsky.social @davidbalchin.bsky.social, @hemmo-lab.bsky.social, Ian Ganley, @kirsteinlab.bsky.social, Juliette Fedry, @elliottlab.bsky.social & @plantophagy.bsky.social - BIG THANKS for accepting the invitation 🙏

The accessory adapters FAF1, FAF2, and UBXN7 accelerate proteasomal degradation by increasing prior p97-mediated substrate unfolding A group of accessory adapters positions the p97 adapter Ufd1 to boost substrate unfolding and subsequent proteasomal degradation.

VCP/p97’s accessory adapters (FAF1, FAF2, UBXN7) boost unfolding and subsequent proteasomal degradation. #ubiquitin. Our paper is out now:
Science Advances www.science.org/doi/10.1126/...

I am incredibly excited to share that I will start my independent lab at the @unidue-zmb.bsky.social at the @unidue.bsky.social as Junior Professor of Cellular Biochemistry. Research in my lab has the goal to decipher the ubiquitin code!
There are multiple open positions!
(1/3)

Allosteric PROTACs: Expanding the Horizon of Targeted Protein Degradation Proteolysis-targeting chimeras (PROTACs) have transformed the concept of chemical intervention in biological systems by co-opting the ubiquitin–proteasome system to selectively degrade proteins. A key...

Allosteric PROTACs: Expanding the Horizon of Targeted Protein Degradation | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...

The date on the poster says February 5…should be March 5, right?

Super excited to present out work at @mitotalks.bsky.social this Thursday!! Hope to see you there!

Congratulations to the winners of this year's Art of Science Image contest at #bps2026

🥇 1st Place: Yupeng Li, University of Illinois Urbana-Champaign
🥈 2nd Place: Jessica Heebner, Thermo Fisher Scientific
🥉 3rd Place: Sohaib Abdul Rehman, Harvard University

Temporal proteomic and phosphoproteomic dynamics during neuronal differentiation of iPSC
www.science.org/doi/10.1126/...

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly - Nature CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand.
www.nature.com/articles/s41...

STARD3 regulates lysosome positioning and contacts via a GSK3-controlled phosphorylation switch - The EMBO Journal Membrane contact sites (MCS) are dynamic regions where the membranes of two organelles come into close apposition. MCSs play many roles in cellular homeostasis by facilitating inter-organelle lipid ex...

The cholesterol transfer protein STARD3 regulates late-endosome positioning via a GSK3-controlled phosphorylation switch
Catherine Tomasetto, @fabienalpy.bsky.social
link.springer.com/article/10.1...

Psycholinguistic perspectives on face-to-face conversation - Nature Reviews Psychology Language production and comprehension are often studied as separate processes, but they are intertwined in naturalistic conversation. In this Review, Holler and Kuhlen summarize how visual signals, feedback and multi-party interactions contribute to language processing and require further study.

A Review in Nature Reviews Psychology summarizes how visual signals, feedback and multi-party interactions contribute to language processing during conversation and require further study. 🔒

Cross-organ metabolite production and consumption in healthy and atherogenic conditions An atlas mapping organ-specific metabolite production and consumption across various pathophysiological states in pigs shows impaired metabolic activity across organs by a Western diet or hypercholest...

This is such an incredible paper. Must read if you care about metabolites and cores organ interactions. For me most interesting finding is that the liver is NOT the only organ that converts cholesterol to bile acids. But ther are so many cool onserbwtions www.cell.com/cell/abstrac...

Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis
www.cell.com/molecular-ce...

1/ Updated preprint (v2) out on bioRxiv! A wonderful team effort with @nancyts.bsky.social, Lake-Ee Quek and others.

“Capacity-Contribution Paradox: Fatty Acid Oxidation Compensates for Low Glucose-Derived Acetyl-CoA in Cancer”

Link:
www.biorxiv.org/content/10.1...

The Lipid Interactome: an interactive and open access platform for exploring cellular lipid–protein interactions AbstractSummary. Lipid–protein interactions play essential roles in cellular signaling and membrane dynamics, yet their systematic characterization has lon

This is SO COOL!!!

academic.oup.com/bioinformati...

First-of-a-kind stem cell therapies set for approval in Japan Regenerative medicines are headed for people with Parkinson’s disease or severe heart failure — but researchers are concerned about minimal clinical-trial data.

Regenerative medicines are headed for people with Parkinson’s disease or severe heart failure — but researchers are concerned about minimal clinical-trial data

go.nature.com/4cKk3yp

A Functional Genetic Atlas of Parkin Resolves Variants of Uncertain Significance and Predicts Parkinson's Disease Age at Onset https://www.biorxiv.org/content/10.64898/2026.02.09.704817v1

Very interesting

Would be good to adopt these method for other E3s

Happy to share our newest preprint on Parkin missense variants in work led by Erna Sol &
@vvouts.bsky.social in @rhp-lab.bsky.social

Using a multiplexed assay we determined the effects of 9,212 out of 9,300 single amino acid substitutions and nonsense Parkin variants. 1/n

doi.org/10.64898/202...

An impressive effort

Really important to help guide E3 experiments and further insights

We posted a biorxiv preprint on structural bioinformatics, AlphaFold modeling & machine learning on predicting specificity of E3 ligase ring domains for different E2 enzymes. 1/4

Preprint: www.biorxiv.org/content/10.6...

Models/data (UbiqCore website): dunbrack.fccc.edu/ubiqcore

A pharmacological modality to sequester homomeric proteins - Nature Chemical Biology Polymerization-inducing chimeras are a novel bifunctional modality that uses protein symmetry to sequester targets by forming insoluble supramolecular assemblies. This approach overcomes reliance on a...

Polymerization-inducing chimeras (PINCHs) are a novel bifunctional modality that sequesters target homodimers in a polymeric state, thereby inhibiting their function

www.nature.com/articles/s41...

Our paper is out in @natcomms.nature.com! APOBEC3s drive mutagenesis in cancer. We uncover a novel pathway keeping them in check. The key is APOBEC3 binding of cellular RNAs, which simultaneously controls their nuclear localization and shields them from degradation.

Read it here: rdcu.be/e4qaa

Neuroimmunometabolism in Health and Disease
Review @annualreviews.bsky.social
www.annualreviews.org/content/jour...

All good things come in pairs...

Proud to share our work in @cp-cellreports.bsky.social and @cp-iscience.bsky.social

An end to an era on a high note 🥂

XIII-ZOMES & 11th Proteasome Joint Meeting
📍 Montpellier, South of France
📅 27–30 April 2026

www.biolum.cnrs.fr/animation-sc...

Focus on proteasome, COP9 signalosome & eIF3 (PCI) in protein homeostasis/pathology, with great speakers + selected talks.

Info/registration: 13-zomes.sciencesconf.org

TRIM21 amplifies IL-17A signaling in cardiac fibroblasts through TRAF3 degradation, forming a self-reinforcing positive feedback loop @pnas.org
www.pnas.org/doi/10.1073/...

CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome - Nature An orthosteric CSN inhibitor gains nanomolar potency via a molecular-glue mechanism, stabilizing a CSN5–N8–inhibitor complex that confers substrate-dependent inhibition despite weak free-enzyme affinity.

Nature research paper: CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome

go.nature.com/4kwdCRy

Some cool E3 ligase structures here with calmodulin-mediated oligomerisation. Also interesting collection/processing to deal with preferred orientation.

www.biorxiv.org/content/10.6...