Sveta Molchanova

The brain is incredibly densely connected. Human cerebral cortex may have as many as *one trillion* connections.

Most of those cortical connections are recurrent, inside each area. What do they do?

New paper from me in Annual Reviews: 🧪 🧠📈 1/

www.annualreviews.org/content/jour...

Hi! Do you know anything about the third edition of “Mechanisms of memory” book by David Sweat? Looks like it’s published, but not in a library or in sale… Or, any other suggestions on a book for students learning mechanisms of synaptic plasticity? Thanks 🙏☺️

#neuroskyence

Newly characterized striatal circuits add twist to ‘go/no-go’ model of movement control The two novel pathways control dopamine release in opposing ways and may link motivation and mood to action, a new study shows.

Tracing circuits from structures in the striatum called striosomes revealed two new pathways that could potentially influence movement.

By @claudia-lopez.bsky.social

#neuroskyence

www.thetransmitter.org/basal-gangli...

The new science of menopause: these emerging therapies could change women’s health Researchers are exploring how to prolong ovarian life and revisiting hormone replacement therapy — a once routine treatment that has fallen out of favour.

After decades of neglect, research funding for menopause, as well as public awareness, are now on the rise

https://go.nature.com/4awi65J

That’s a good news, strangely enough ELFN1 association to ADHD-like traits has not been shown before (or I haven’t seen that)

Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations Complex disorders require precise strategies for their characterization. AI-based digital phenotypes from biosensors can be used to predict psychiatric disorders and identify GWAS loci.

Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations www.cell.com/cell/fulltex... - interesting approach, but a very small sample for GWAS!

‘Never seen anything like this’: Trump’s team halts NIH meetings and travel In an unprecedented move, research-grant reviews have been suspended indefinitely at the world’s largest public funder of biomedical research.

In an unprecedented move, research-grant reviews have been suspended indefinitely at the world’s largest public funder of biomedical research

https://go.nature.com/4gc0Bc5

X chromosome passed from mother to daughter influences brain ageing X-chromosome inactivation affects age-related decline in spatial memory.

This phenomenon could be responsible for variation in age-related cognitive decline among women

https://go.nature.com/40ucdkX

Identification of the subventricular tegmental nucleus as brainstem reward center Rewards are essential for motivation, decision-making, memory, and mental health. We identified the subventricular tegmental nucleus (SVTg) as a brainstem reward center. In mice, reward and its predic...

Identification of the subventricular tegmental nucleus as brainstem reward center | Science www.science.org/doi/10.1126/... - amazing work! Really shows how little we know when a completely new player in something as central as reward signaling is discovered!