Esther Uijttewaal

CRISPR-StAR enables high-resolution genetic screening in complex in vivo models - Nature Biotechnology Pooled genetic CRISPR screening is improved in complex models through leveraging internal controls.

My PhD work is published! 🌟 We developed CRISPR-StAR, a new genetic screening method that uses internal controls that face the same challenges as edited cells—making the results more robust. In therapy-resistant melanoma, we revealed differential genetic dependencies in vitro and in vivo. Curious?

CRISPR-StAR enables high-resolution genetic screening in complex in vivo models - Nature Biotechnology Pooled genetic CRISPR screening is improved in complex models through leveraging internal controls.

Today we published a new paradigm to do CRISPR screens in complex model systems such as in vivo but also e.g. in organoids. The publication came out in Nature Biotechnology.
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www.nature.com/articles/s41...