Lange lab @ Aarhus University/SDCA/UC San Diego

we are losing so much talent, progress, and hope for no good reason www.vox.com/future-perfe...

Chief Executive Officer - New York City, New York (US) job with arXiv | 37961678 arXiv seeks its first CEO to champion open, free scientific discovery and guide the platform’s next chapter as an independent nonprofit.

The arXiv is becoming a nonprofit separate from Cornell, and they're looking for a CEO. Please repost to let good candidates know!
@dabacon.tachyon.institute, @harrowing.bsky.social, @michaelnielsen.bsky.social
jobs.chronicle.com/job/37961678...

Abruptly switching to multiyear funding means the same annual budget gets allocated to far fewer projects, making it even harder to get grants. Congress may have shot down the drastic budget cuts proposed by the White House, but the NIH is finding other ways to award fewer grants. Fight’s not over.

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

For a variety of reasons, the apparent "payline" from a graph is somewhat lower than the estimated success rate.

Some institutes, primarily NIGMS, are moving away from R01s to R35 (MIRA) mechanisms.

24/25

A line graph showing the fraction of R01 applications funded as a function of percentile for NHLBI. The estimated success rate for FY2024 was 17.9% compared with 14.9% for FY2025.

6/25

A line graph showing the fraction of R01 applications funded as a function of percentile for NIA. The estimated success rate for FY2024 was 15.8% compared with 5.8% for FY2025.

12/25

Trump Administration Plans to Break Up NCAR - Eos The Trump administration is planning to dismantle the National Center for Atmospheric Research, one of the world’s leading climate and Earth science research laboratories, according to a statement fro...

Update: Bidders have begun lining up to take over management of NCAR, @science.org reports.

eos.org/research-and...

NIH has not updated the overall success rates pages The NIH finally updated the data underlying good ol’ Report 302 of the Databook to include FY2025, which ended 09/30/2025. This allows us to examine the fate of R01-Equivalent applications by…

NIH has not updated the overall success rates pages drugmonkey.wordpress.com/2026/03/12/n...

The Unmaking of the American University For decades, research universities have relied on federal funding, with no guarantee that it will last. Now their survival may depend on compliance with the government.

The Trump Administration is waging war on universities by suspending their funds. N.I.H. grants to universities are down by more than 90 per cent in the current fiscal year; so far in 2026, the National Cancer Institute hasn’t made a single grant. newyorkermag.visitlink.me/oxA7Ey

Highlights:
- sex/drug-dependent localization of extracellular matrix components to cardiac intercalated disks: Lox, Mmp9, Collagen XI
- alleviated DCM-associated intercalated disk phenotype in lipoxin-treated male MLPko, linked to downregulation of pathological Ankrd1/PKC signaling

We found profound sex-specific effects of lipoxin action. Male MLPko mice showed alleviation of some DCM symptoms (ventricular chamber dilation, inflammation, cardiac DCM signaling, intercalated disk phenotype). Females were surprisingly unresponsive to lipoxin therapy.

Madison Clark and colleagues aimed to alleviate #dilated #cardiomyopathy (DCM) in MLPko mice by targeting DCM-linked inflammation by administration of lipoxins, special pro-resolving lipid mediators.

The picture shows some figures from the manuscript

New preprint alert from our lab 🚨
Lipoxins Regulate Intercalated Disk-Associated Signaling and Immune Remodeling in Dilated Cardiomyopathy

www.biorxiv.org/content/10.6...

#dilated #cardiomyopathy #DCM #cardiac #inflammation #sex-specificity #lipoxin #intercalated-disk #myoblue

NYT headline: First 6 days of Iran War Cost US $11.3 billion, Pentagon says

The ERC budget for 2026 is 2.7 billion euros 🧪

NIH director launches "Scientific Freedom" lectures with non-scientist First speaker minimizes climate change, COVID risks—and is a lab leak proponent.

The jokes write themselves.

arstechnica.com/science/2026...

eLife Fallout When a prestigious journal scrapped accept-reject decisions on submitted papers, some scientists rebelled, and the editor-in-chief was fired.

This account of the eLife saga will provoke much debate. One aspect isn't accurate: eLife wasn't "designed as an experiment in removing gatekeepers". The original intent was to publish "outstanding papers" but have the gatekeepers be academic not professional editors 1/2 nikomc.com/2026/03/05/e...

Career effects of preprints get mixed reviews from biomedical researchers Junior researchers are more likely to embrace preprints; grant reviewers and hiring committees express doubts

Nearly half of biomedical scientists worry preprints could spread shoddy research and misinformation, according to a new survey that could help explain why the life sciences have taken up the publishing practice more slowly than some other fields. https://scim.ag/3PsbLBC

The Unmaking of the American University For decades, research universities have relied on federal funding, with no guarantee that it will last. Now their survival may depend on compliance with the government.

Donald Trump could do much more damage to universities during the rest of his Presidential term—or he could lose interest. That would not solve the universities’ problem of thick dependency on the government and thin political support. newyorkermag.visitlink.me/IjKXTJ

The reductions in the number of new and competing renewal R01s by topic (based on simple searches in NIH Reporter).

The cuts are across the board: Cancer down 24%, Alzheimer down 45%, Obesity down 29%, Child by 21%.

Transgender was down by 84% but represents only a small number of grants.

NIH FY2025 funding data finally emerges on RePORT The FY2025 funding picture was disrupted significantly by the mandate for Multi-Year Funding of about half of the budget for extramural awards. This produced a mid-year declaration by NCI that thei…

NIH FY2025 funding data finally emerges on RePORT drugmonkey.wordpress.com/2026/03/06/n...

My lab @cri-utsw.bsky.social is looking for a highly motivated postdoct interested in mechanobiology!

We are building a highly collaborative and interdisciplinary team working on how mechanical forces shape immune and cancer cell behavior.

Come do cool science with me!

lnkd.in/gKEXWUGy

Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

Postdoc positions available in my lab in Aarhus, Denmark on 'Mammalian Nuclear RNA Production and Turnover Systems'. Please get in touch for further information or simply apply here:
mbg.au.dk/en/news-and-...

A photo of Doc Brown from Back to the Future holding jumper cables labelled "Deranged Activist" with a grant of NIH funding curves below it.

My weekly update on NIH funding

This includes awards made through 2/27/26

Warning: This thread contains data compiled by a known deranged_activist™. Do not read while operating heavy machinery.

1/9

On sabotage of our young scientists, by @holdenthorp.bsky.social @science.org
www.science.org/doi/10.1126/...

Delays in awards and funding calls worry NIH-funded researchers Many programs may be pushed into the next fiscal year, and some could face funding gaps

“Since Trump took office 13 months ago, NIH has posted only 84 NOFOs, down from 787 in the previous year. Many more are in limbo. NIH has 323 opportunities listed as ‘forecasted.’ “

Seems like an innovative and exciting research environment for early career folks!

www.science.org/content/arti...

First PhD dissertation of the lab at Aarhus University submitted. Congratulations to Virginia. Great feat!
Now onto the viva!

A line graph showing NSF grant awards made through 2/27/26 for fiscal year 2026 compared with grant awards for fiscal years 2021-2025.

NSF Update (Awards through 2/27/26)

Directorates to follow

1/10

Not spending money that is appropriated for science is a tricky subject to explain, but for people in limbo (like myself, as I mentioned yesterday), it can have cause serious career harm.

Many celebrated the NIH budget bill. It’s not supporting science when an unchecked bottleneck still remains.

Job losses at research-intensive universities double in two years - Research Professional News Exclusive: Scale of redundancies revealed branded a “disaster” for UK research capacity

Job losses at UK research-intensive universities double in two years.

Exclusive: Scale of redundancies branded a “disaster”.

www.researchprofessionalnews.com/rr-news-uk-u...