Rafael Lameiro's Avatar

Rafael Lameiro

@rflameiro

🇧🇷 PhD student using Python and Machine Learning in Cheminformatics research for Medicinal/Biological Chemistry. Fascinated by plants and the human brain.

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11.08.2023
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Latest posts by Rafael Lameiro @rflameiro

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What will it take for AI to change drug discovery? Some thoughts on avoiding self delusion.

And I think it goes well with this blog post that discusses other issues around "AI will solve drug design", in specific, that finding leads is just the tip of the iceberg. www.writingruxandrabio.com/p/what-will-...

17.02.2026 04:07 👍 0 🔁 0 💬 0 📌 0
Why AI Can’t Produce Novelty: How to Build Workflows for IP Generation
Why AI Can’t Produce Novelty: How to Build Workflows for IP Generation YouTube video by BioSolveITTutorials

Watched this webinar www.youtube.com/watch?v=Q7sn... by BioSolveIT. Very nice thoughts on the limits of AI in creating novelty and some strategies to overcome this +

17.02.2026 04:07 👍 0 🔁 0 💬 1 📌 0
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What Makes A Drug

What Makes A Drug | Science | AAAS www.science.org/content/blog...

16.02.2026 15:35 👍 0 🔁 0 💬 0 📌 0
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Machine Learning‐Guided Repositioning of a SARS‐CoV‐2‐Targeting Molecular Series as Cruzain Inhibitors An ExtraTrees machine learning (ML) model is used to reposition a SARS-CoV-2-directed library of peptidomimetic compounds as cruzain inhibitors for Chagas disease. Potent binders with a novel P1 moie...

Another paper from my doctoral project has been published in ChemMedChem.

You can check out "Machine Learning-Guided Repositioning of a SARS-CoV-2-Targeting Molecular Series as Cruzain Inhibitors" here: doi.org/10.1002/cmdc...

03.02.2026 19:34 👍 0 🔁 0 💬 0 📌 0

Registration is now open at www.ebi.ac.uk/about/events...

14.01.2026 17:50 👍 1 🔁 2 💬 0 📌 0
Como é feita a vidraria de LABORATÓRIO
Como é feita a vidraria de LABORATÓRIO YouTube video by Bounty Breaker

Glassblowing a condenser! Things we take for granted
youtube.com/shorts/uNeLv...

15.01.2026 19:13 👍 0 🔁 0 💬 0 📌 1
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The Secret Agent wins Best Motion Picture — Non-English Language 🏆

#GoldenGlobes

12.01.2026 03:09 👍 851 🔁 297 💬 13 📌 92

Editing the bibliography in my thesis and I have to say, without AI it would have taken me much more than a whole day to properly format the .csl file... 😩
By the way, ChatGPT helped a lot, but Copilot seems to know more about the intricacies of the .csl format

07.01.2026 03:06 👍 0 🔁 0 💬 0 📌 0
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The productivity paradox of AI coding assistants AI coding assistants promise speed, but do they deliver? Explore data, developer insights, and security risks showing why AI feels faster but often slows production. Learn where tools like Cursor and ...

It's a weird time to be working with programming
AI coding makes you slower, not faster www.cerbos.dev/blog/product...

16.12.2025 20:28 👍 3 🔁 0 💬 0 📌 0
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Brain’s ‘plumbing’ inspires new Alzheimer’s strategies—and controversial surgeries Animal studies support idea that boosting fluid clearance could blunt neurological disorders

Brain’s ‘plumbing’ inspires new Alzheimer’s strategies—and controversial surgeries | Science | AAAS www.science.org/content/arti...

16.12.2025 19:00 👍 1 🔁 0 💬 0 📌 0
CRISPR Just Saved a Baby’s Life… Millions Could Follow
CRISPR Just Saved a Baby’s Life… Millions Could Follow YouTube video by SciShow

Exciting times ahead. Just hope it won't cost a fortune
youtu.be/nVQo76iEoms?...

07.12.2025 21:03 👍 1 🔁 0 💬 0 📌 0
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Drugmakers share data to feed voracious foundation models - Nature Biotechnology Big pharma shares its machine learning models with biotechs, but awaits definitive data on success of artificial intelligence-generated drugs.

www.nature.com/articles/s41...

24.11.2025 01:12 👍 2 🔁 1 💬 0 📌 0

overall very interesting, and a nice message at the end

03.10.2025 22:15 👍 0 🔁 0 💬 0 📌 0
Something Strange Happens When You Trace How Connected We Are
Something Strange Happens When You Trace How Connected We Are YouTube video by Veritasium

Something Strange Happens When You Trace How Connected We Are

Watch our latest video, in full, on YouTube - youtu.be/CYlon2tvywA

01.10.2025 15:47 👍 55 🔁 11 💬 5 📌 10
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1500 on Lichess for the first time 🥳

28.09.2025 21:14 👍 1 🔁 0 💬 0 📌 0

nascer no Brasil tem suas vantagens

18.09.2025 21:42 👍 0 🔁 0 💬 0 📌 0
containers made of "Favrile glass", an opalescent glass

containers made of "Favrile glass", an opalescent glass

Today I learned about "Favrile glass", an opalescent glass. Much prettier live than in the photo, sadly fell out of fashion in the 1910s

13.09.2025 18:52 👍 0 🔁 0 💬 0 📌 0

We are looking for a 3-year postdoc to work with Daniel Probst, Justin van der Hooft and myself on an exciting project involving federated learning and integrative omics for discovery of new antibiotics from natural products.
Apply here: www.wur.nl/en/vacancy/p...
Please share!

08.09.2025 09:07 👍 31 🔁 32 💬 1 📌 3
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Yousuf Karsh - Wikipedia

TIL. Iconic pictures
en.m.wikipedia.org/wiki/Yousuf_...

04.09.2025 18:48 👍 0 🔁 0 💬 0 📌 0

Link is not working, Pete

06.08.2025 10:41 👍 0 🔁 0 💬 1 📌 0

Just finished reading "The Alchemy of Air" by Thomas Hager. An unexpected find (a Canadian copy purchased second hand in Brazil!) with a really well written account of possibly the most impactful chemical reaction discovered by man. I definitely recommend it

03.06.2025 01:34 👍 0 🔁 0 💬 0 📌 0
Cartão preto com texto branco postado no Instagram pelo perfil @ostreselementospodcast. No topo, lê-se “COMUNICADO” com um traço abaixo. O texto informa que o divulgador científico Pirulla sofreu um AVC (acidente vascular cerebral) na noite de domingo, 25 de maio, em sua casa, em São Paulo. Ele foi prontamente atendido e está internado em uma UTI, em estado estável, mas que ainda inspira cuidados. O comunicado também destaca que não há previsão segura de recuperação. A comunidade científica e amigos próximos estão se mobilizando para ajudar sua família e manter seus canais funcionando durante esse período.

Cartão preto com texto branco postado no Instagram pelo perfil @ostreselementospodcast. No topo, lê-se “COMUNICADO” com um traço abaixo. O texto informa que o divulgador científico Pirulla sofreu um AVC (acidente vascular cerebral) na noite de domingo, 25 de maio, em sua casa, em São Paulo. Ele foi prontamente atendido e está internado em uma UTI, em estado estável, mas que ainda inspira cuidados. O comunicado também destaca que não há previsão segura de recuperação. A comunidade científica e amigos próximos estão se mobilizando para ajudar sua família e manter seus canais funcionando durante esse período.

Imagem de fundo preto com texto branco postada no perfil @ostreselementospodcast. O comunicado solicita que evitem especulações e respeitem a privacidade de Pirulla e de sua família. Informa que atualizações oficiais serão feitas nos canais do Pirulla e nas redes d’Os Três Elementos. Também convida a colaborar financeiramente com a recuperação do divulgador por meio do site www.pirulla.com.br. A mensagem é assinada pela família de Pirulla e pela equipe do podcast.

Imagem de fundo preto com texto branco postada no perfil @ostreselementospodcast. O comunicado solicita que evitem especulações e respeitem a privacidade de Pirulla e de sua família. Informa que atualizações oficiais serão feitas nos canais do Pirulla e nas redes d’Os Três Elementos. Também convida a colaborar financeiramente com a recuperação do divulgador por meio do site www.pirulla.com.br. A mensagem é assinada pela família de Pirulla e pela equipe do podcast.

pirulla.com.br

30.05.2025 20:00 👍 417 🔁 154 💬 16 📌 39
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essa é nova, primeiro de Abril fora de hora?

31.05.2025 02:45 👍 1 🔁 0 💬 0 📌 0

Nice, but I still don't know how to declare race/ethnicity on forms outside of Brazil 🤔

17.05.2025 01:42 👍 1 🔁 0 💬 0 📌 0
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Doctors Told Him He Was Going to Die. Then A.I. Saved His Life. Scientists are using machine learning to find new treatments among thousands of old medicines.

Repurposing might be one of the best uses of AI in drug research. Just feed it all the knowledge available and hope for the best 😅
Doctors Told Him He Was Going to Die. Then A.I. Saved His Life. www.nytimes.com/2025/03/20/w...

15.04.2025 14:30 👍 0 🔁 0 💬 0 📌 0

They forgot to mention blockchain and quantum computing

04.04.2025 03:37 👍 1 🔁 0 💬 0 📌 0

Não demora pra sair a lei tornando crime pintar estradas do Coiote em muros

22.03.2025 03:25 👍 113 🔁 2 💬 2 📌 0
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I'm Still Here wins Best International Feature Film at the #Oscars

This is the first win for Brazil in this category.

03.03.2025 02:59 👍 2898 🔁 869 💬 38 📌 105
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‘Ainda Estou Aqui’ ganha Oscar de melhor filme internacional glo.bo/41BZ8aV

03.03.2025 02:57 👍 2575 🔁 646 💬 30 📌 90

I remembered the work by Lipkus and thought the answer would be "yes". Thanks for pointing out that it only applies to binary vectors

23.02.2025 20:21 👍 1 🔁 0 💬 1 📌 0