Jean Nakhle

New Editorial in @natmetabolism.nature.com for World Obesity Day 📆

✨New issue✨

Check out the latest in #Metabolism research from across all disciplines. 🧪

Read about #AdiposeInnervation, #Amylin, #Cancer, #LiverMetabolism, #MitochondrialMetabolism, #Mycobiome, #Neurometabolism, #Redox, #T2D and many more topics!

www.nature.com/natmetab/vol...

Single-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture - Nature Metabolism Using the single-cell Deep Visual Proteomics technique, the authors develop a resource providing spatially resolved proteomic analysis of individual cells in human liver tissue.

Ever wondered how the human liver looks like at single-cell, spatial protein resolution? We used single-cell Deep Visual Proteomics to map human liver zonation at the protein level - one hepatocyte at a time. Our paper is out in @natmetabolism.nature.com! www.nature.com/articles/s42...

PFKM governs metabolic shifts throughout skeletal muscle differentiation - Nature Metabolism Subcellular compartmentalization of the glycolytic enzyme PFKM regulates cell fate and metabolic switch during skeletal muscle differentiation.

Excited to share our latest work out today in @naturemetabolism.bsky.social @ucirvine.bsky.social www.nature.com/articles/s42...

Feeding-regulated glycogen metabolism drives rhythmic liver protein secretion - Nature Metabolism Hepatic glycogenolysis is essential for protein glycosylation and rhythmic secretion by the liver. Disruptions to hepatic glycogenolysis, caused by congenital diseases or physiological factors such as...

Our study is out today 🎉 in @natmetabolism.nature.com. The liver doesn’t secrete proteins nonstop; it follows a daily rhythm. Meal timing controls liver protein release via glycogen metabolism, and disrupted eating blunts these rhythms. A 🧵 ...

Metabolic Messengers: testosterone - Nature Metabolism Mauvais-Jarvis and Bhasin provide an in-depth review of testosterone’s role in maintaining cardiometabolic health, musculoskeletal integrity and energy balance, drawing on evidence from testosterone replacement therapy in humans and mechanistic research in rodent models.

METABOLIC MESSENGERS | Testosterone

S Bhasin, F Mauvais-Jarvis
@harvardmed.bsky.social, @tulanemedicine.bsky.social

Testosterone’s role in cardiometabolic & musculoskeletal health 🧪

✨New issue✨

Check out the latest in #Metabolism research from across all disciplines.

Read about #AMPK, #Cachexia, #ImmuneSignalling, #Microbiome, #NAD, #Nutrition, #TissueCrosstalk and many more topics! 🧪

www.nature.com/natmetab/vol...

Hallmarks of cancer—Then and now, and beyond Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of conceptual refinement into a multidimensional view of tumor biology. This review highlights how aberrant capabilit...

Today at Cell: A new #HallmarksofCancer review by Doug Hanahan: www.cell.com/cell/fulltex...
This review marks 25 years since the original seminal Cell review by Hanahan & Robert Weinberg and its impactful follow up in 2011.
@cp-cell.bsky.social @cellpress.bsky.social

The transition from monocyte to tissue-resident macrophage requires DHPS - Nature In mice, DHPS supports the maturation, maintenance and function of tissue-resident macrophages via the polyamine–hypusine axis, with implications for macrophage-targeting therapies.

Nature research paper: The transition from monocyte to tissue-resident macrophage requires DHPS

go.nature.com/4sSiFPX

ADHD: The quest to understand and treat a pervasive and mystifying mental health condition. @nature.com

#Research by Rémi Montané of toulouseuniversite.bsky.social et al. observes that brown #adipose tissue activity impacts systemic #lactate clearance in male mice 🔬 📉

📜 Read the study here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance - Nature Metabolism Neri et al. develop elegant tools to understand how the sympathetic nervous system regulates intrascapular brown adipose tissue (iBAT) function. Using these tools, they find that sympathetic nerves ta...

Distinct neurons, distinct functions 🧠🟤 Our Nature Metabolism paper (now out!) shows that separate sympathetic projections to brown adipose tissue independently control thermogenesis and glucose tolerance. Congrats Daniele Neri and team 🥳

www.nature.com/articles/s42...

A foundation model for continuous glucose monitoring data - Nature GluFormer, a generative foundation model, uses continuous glucose monitoring data to accurately forecast glycaemia-related health responses, particularly for long-term outcomes.

Nature research paper: A foundation model for continuous glucose monitoring data

go.nature.com/3LkpysA

Heterogeneous sympathetic control of brown adipose tissue - Nature Metabolism In this issue of Nature Metabolism, Neri et al. show that two distinct stellate ganglion subcircuits innervating interscapular brown adipose tissue (iBAT) separately control thermogenesis and glucose ...

Read the accompanying News & Vews by @liye-tsri.bsky.social here:

Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance - Nature Metabolism Neri et al. develop elegant tools to understand how the sympathetic nervous system regulates intrascapular brown adipose tissue (iBAT) function. Using these tools, they find that sympathetic nerves ta...

Out now in @natmetabolism.nature.com 🧪

@zeltserlab.bsky.social et al. provide a mechanistic explanation of how the thermogenic and glucoregulatory functions of BAT are controlled by molecularly, anatomically, and functionally distinct neuronal populations within the stellate ganglion.

Read the accompanying News & Views here:

Chronic stress drives liver cancer by impairing the hepatic kynurenine pathway and immune surveillance - Nature Metabolism Psychological stress-mediated dysregulation of catecholamine signalling rewires the hepatic kynurenine pathway, which in turn impairs liver CD8+ T cell function and promotes liver cancer progression.

Out now in #NatureMetabolism 🧪

How does psychological stress influence tumor development?

Chronic stress disrupts catecholamine signalling, which in turn rewires the hepatic kynurenine pathway. This shift suppresses hepatic CD8⁺ T cell activity and promotes immune evasion.

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

Language model-guided anticipation and discovery of mammalian metabolites - Nature Chemical language models trained on known metabolites can identify previously unknown metabolites from mass spectrometry-based metabolomics data with high accuracy.

Nature research paper: Language model-guided anticipation and discovery of mammalian metabolites

go.nature.com/4b1vrFk

Nutritional advice on social media: clicks over credibility - Nature Metabolism Social media has become a go-to source for nutritional advice, and a space in which influencers compete with, and often drown out, evidence-based guidance. The scientific community should counter this viral spread of misinformation by making trustworthy information more accessible.

EDITORIAL | Nutritional advice on social media: clicks over credibility

Social media based nutritional misinformation can lead to poorly managed health conditions. Experts need to adapt and engage effectively to counteract this trend. 🧪

www.nature.com/articles/s42...

Out now in @natmetabolism.nature.com 🧪

Mauvais-Jarvis and Bhasin provide a review of testosterone’s role in maintaining cardiometabolic health, musculoskeletal integrity and energy balance, drawing on evidence from humans and rodents.

doi.org/10.1038/s422...

Out now in @natmetabolism.nature.com 🧪

Elevated adipocyte-derived AFABP in obesity binds to plasma transferrin which leads to iron overload in intestinal stem cells (ISCs). Disruption of iron homeostasis impairs PPARα signalling and blocks ISC differentiation after injury.

doi.org/10.1038/s422...

Nutrient requirements of organ-specific metastasis in breast cancer - Nature How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.

new out in Nature www.nature.com/articles/s41...

🎂

✨New issue✨

Check out the latest in #Metabolism research from across all disciplines.

Read about #Cognition, #FoodCues, #Microbiome, #Neurometabolism, #Regeneration, #Tumor biology and many more topics! 🧪

www.nature.com/natmetab/vol...

HAPPY HOLIDAYS TO ALL OF YOU!🎄✨

EMito-Metrix enables automated evaluation of mitochondrial morphology across species - Nature Metabolism

#Throwback 🧪
CORRESPONDENCE | EMito-Metrix enables automated evaluation of mitochondrial morphology across species
JP Pradère et al.

Watch this space 😉