We built DNA scaffold crystals that can be reprogrammed to host different guest proteins for X-ray structure determination — no new crystallization screen required. This animation shows a guest protein (glowing) seeking its designed binding site inside the crystal lattice. shorturl.at/DANdc
Pois é, a impressão que sempre me deu é que, se houvesse a oportunidade, fariam PPP.
Mas na área de desenvolvimento de fármacos isso é raríssimo, não? Eu convivo com o pessoal dessa área desde os anos 2000 e quase sempre vejo o contrário.
grupo onde eu tava em que perguntaram como fazer para colaborar com eles e ele basicamente respondeu que seria quando tivesse quase um produto pronto. Aí fica difícil mesmo passar da pesquisa básica pro fármaco. Ao contrário do que diz o lugar comum, o setor privado não gosta de correr risco.
Aí eu vou discordar um pouco, essa "resistência" dentro da academia está longe de ser o maior motivo disso não acontecer, muito maior é a resistência do próprio setor privado, que não tem interesse em desenvolvimento. Lembro duma palestra de um representante de uma farmacêutica há uns 20 anos no (+)
Mosquitoes like Aedes aegypti spread viruses that cause major global diseases. We decided to have a closer look at a family of mosquito carbohydrate-binding proteins involved in infecting these vector species. We found some unexpected things 😁
Preprint out now 🦟🦟🦟
www.biorxiv.org/content/10.6...
Lendo esse livro aqui sobre a alma mater e estou achando excelente!
editora.ufc.br/pt/catalogo/...
The media should be PRAISING these athletes who know and understand the importance of public health. These articles should be about how they are setting an example for EVERYONE. And how we should all take their lead.
Instead their positioning is: “look at these fucking weirdos”
Check out our new review in Nature Reviews Genetics on de novo emerged genes and proteins. How they emerge, are lost and persist - and how de novo emerged proteins relate to randomized proteins! @bornberglab.bsky.social www.nature.com/articles/s41...
Our lab will be boycotting biotech vendors that have contracts with ICE (e.g., Fisher, Agilent), and telling them why. If you google “vendorname usa spending”, you can see purchases for specific depts including ICE on usaspending.gov. Please talk to your labs and email your vendors!
Já recebi *várias vezes* convites para publicar numa chamada "Journal of Rice Science" e em outra de ginecologia e obstetrícia. Minha área não tem absolutamente nada a ver com nenhuma das duas, aliás.
Aí pensei que poderia escrever sobre vontade de comer arroz na gravidez e mandar logo pras duas.
This is so incredibly heart-breaking. To Jay Bhattacharya and Matthew Memoli at NIH--you have betrayed the entire scientific community. Deeply committed staff are leaving in droves--because you are destroying the institution. Shame on you. www.statnews.com/2026/01/10/n...
Examples of crystals
Interested in crystallizing your favorite biomolecule for structural studies?
Join the #IUCr2026 Biomolecular Crystallization Workshop for
- Sample prep/characterization
- Optimization and seeding
- Ways to ‘see’ your crystals
- Ultrasmall to large crystals
- AI/ML advances
event.fourwaves.com/...
Tired: Everything evolves to be a crab.
Wired: Everything evolves to eat ants.
Mais uma edição da Journal of Molecular Evolution que eu queria ter em versão impressa pra ler com calma. Esse número é uma edição especial sobre ortólogos.
link.springer.com/journal/239/...
Newsletter nova falando sobre alternativas ao Papanicolau e bobagens de quem ganhou o Nobel.
literaturaqueijof1.substack.com/p/amplifican...
Esse congresso já foi um sucesso estrondoso na primeira edição (em que foi necessário antecipar o encerramento das inscrições ou o local não ia comportar o evento - foram mais de 700 inscritos!), e o próximo, aqui em Belo Horizonte, tem tudo pra ser excelente também!
Great news!
JSTOR now have a free account with an Independent Researcher category. You can access 100 documents per month
www.jstor.org/action/showL...
In the early days of quantum chemistry, before we had computers to calculate the shapes of electron orbitals, one man invented a mechanical machine that simulated their shapes. My latest column for @chemistryworld.com
www.chemistryworld.com/opinion/the-...
I really hate it when scientists keep saying that “we need to rebuild trust in science,” because it implies that scientists are to blame for the mistrust rather than the millions of dollars of dark money that have funded political attacks on science in order to advance a far right agenda.
Watch the Webinar: Searching the PDB for high-quality ligand-bound structures
Learn how to search the PDB for the best examples of ligands using text, chemical drawing, and APIs
After our study on transthyretin and HIUase ancestral reconstruction, I wrote this personal account on how TTRs were present in key moments in my career and on tackling this interesting case of neofunctionalization using crystallography and calorimetry
communities.springernature.com/posts/evolut...
imigração é um direito. fronteiras são inventadas. bichos migram, os seres humanos sempre mudaram de lugar.
(The title of my keynote will be "The critical use of Degenerative AI in Doctoral education" 🔥)
www.linkedin.com/posts/monett...
Very interesting recollection from interviews and the literature on alchemical free-energy methods.
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"THE DAWN OF ALCHEMICAL FREE-ENERGY METHODS IN BIOMOLECULAR SIMULATIONS" (Daniele Macuglia, Giovanni Ciccotti, Benoît Roux)
arxiv.org/pdf/2510.04917
Journal of Molecular Evolution tem artigos tão maravilhosos que fico triste que não exista mais versão impressa, queria tirar um dia por mês pra ir numa biblioteca e ler a última edição.
Players match protein targets with drugs in this game developed by RCSB PDB and @ccdc.cam.ac.uk
Abstract: Under the banner of progress, products have been uncritically adopted or even imposed on users — in past centuries with tobacco and combustion engines, and in the 21st with social media. For these collective blunders, we now regret our involvement or apathy as scientists, and society struggles to put the genie back in the bottle. Currently, we are similarly entangled with artificial intelligence (AI) technology. For example, software updates are rolled out seamlessly and non-consensually, Microsoft Office is bundled with chatbots, and we, our students, and our employers have had no say, as it is not considered a valid position to reject AI technologies in our teaching and research. This is why in June 2025, we co-authored an Open Letter calling on our employers to reverse and rethink their stance on uncritically adopting AI technologies. In this position piece, we expound on why universities must take their role seriously toa) counter the technology industry’s marketing, hype, and harm; and to b) safeguard higher education, critical thinking, expertise, academic freedom, and scientific integrity. We include pointers to relevant work to further inform our colleagues.
Figure 1. A cartoon set theoretic view on various terms (see Table 1) used when discussing the superset AI (black outline, hatched background): LLMs are in orange; ANNs are in magenta; generative models are in blue; and finally, chatbots are in green. Where these intersect, the colours reflect that, e.g. generative adversarial network (GAN) and Boltzmann machine (BM) models are in the purple subset because they are both generative and ANNs. In the case of proprietary closed source models, e.g. OpenAI’s ChatGPT and Apple’s Siri, we cannot verify their implementation and so academics can only make educated guesses (cf. Dingemanse 2025). Undefined terms used above: BERT (Devlin et al. 2019); AlexNet (Krizhevsky et al. 2017); A.L.I.C.E. (Wallace 2009); ELIZA (Weizenbaum 1966); Jabberwacky (Twist 2003); linear discriminant analysis (LDA); quadratic discriminant analysis (QDA).
Table 1. Below some of the typical terminological disarray is untangled. Importantly, none of these terms are orthogonal nor do they exclusively pick out the types of products we may wish to critique or proscribe.
Protecting the Ecosystem of Human Knowledge: Five Principles
Finally! 🤩 Our position piece: Against the Uncritical Adoption of 'AI' Technologies in Academia:
doi.org/10.5281/zeno...
We unpick the tech industry’s marketing, hype, & harm; and we argue for safeguarding higher education, critical
thinking, expertise, academic freedom, & scientific integrity.
1/n
Science is real
