1/ 🎯 A therapeutic target that would curb the spread of #coronaviruses has been identified
It is an enzyme that is activated in human cells in response to stress due to infection and causes changes in the cellular machinery that favour the production and spread of coronaviruses
tuit.cat/5y9Rr
Investigadores de la @ptisg.bsky.social pertenecientes al @i2sysbio.es participan en este estudio, en el que identifican que un coronavirus que infecta a los cerdos utiliza DPEP1 para entrar en las células
New exciting resource published!! The Viro3D paper is out, describing our comprehensive database of predicted virus protein structures! 💻🧬
Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
Virus researchers! Please consider participating in this project - it would be a huge help to our lab, and we think it'll lead to some really exciting synthesis. Plus, you'll get an invitation to participate in a workshop later in the project! 🦠😷
Some good news to push against the dark. Excited to share our latest pre-print from the lab.
www.biorxiv.org/content/10.1...
What started as a series of control experiments rapidly grew into a whole project. 🧪🔬🦠
By mining GISAID, researchers from I2SysBio uncover sequencing artifacts in SARS-CoV-2. Many repair mutations in the spike protein were due to errors in data processing. #covid19 #viruses #microsky🧪🦠💻🧬 More info: www.i2sysbio.es/communicatio... ⬇️
People do forget how common zoonotic exposure is. In this study 12% of people working in the guano industry in Myanmar were seropositive for sarbecoviruses: pmc.ncbi.nlm.nih.gov/articles/PMC...
🚨Job offer at our research institute I2SysBio 🇪🇸: Contract for International Program Management, specialized in ERC @erc.europa.eu programs 🧪 #science #researchgrants #JOBOFFER #i2sysbio @ucciuv.bsky.social @csic.es @uv.es
i2sysbio.es/position/4/
Our recent collaborative work showing the promising broad-spectrum antiviral activity of chitosan sulfate derivatives against SARS-CoV-2, RSV, and Sindbis virus is finally online. Check it out! Detailed mechanisms and in vivo characterization included! rdcu.be/eb9IQ
🚨 Preprint alter - bis 🚨
I am thrilled to share our last preprint where we identify and characterize a new coronavirus receptor! 🦠
This work was done in collaboration with the team of Félix Rey at the Institut Pasteur.
A 🧵 below...
www.biorxiv.org/content/10.1...
To get 2025 off to a good start, I'm delighted to share with you our study published today in @naturemicrobiol.bsky.social 🎉 We studied the ability of the receptor-binding proteins (RBP) of >100 animal viruses to mediate entry into human cells. A short thread below.
www.nature.com/articles/s41...
In new study, we measure how all mutations to rabies G affect cell entry & antibody neutralization
Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation
www.biorxiv.org/content/10.1...
Poliovirus keeps popping up in European wastewater, perplexing and worrying scientists www.science.org/content/arti...
👀👀👀👀👀👀 We should sample more cute animals for weird viruses!!! 🐼🐼
Our research institute I2SysBio🇪🇸 has created a starter pack for researchers in systems biology, everybody is welcome, write us if you want to be added 🔬🧫🧬🖥🦑🦠🌱🦟🪳🪸🌾
I think this is a big assumption! More data is needed to confirm the different evolutionary patterns in envelope acquisition
Excited to share our latest publication on a newly discovered ancestor of Hepadna and Nackednaviruses, found in bat feces in Spain! This discovery provides new insights into the evolution of these virus families and their origins.
Read more in PNAS: www.pnas.org/doi/abs/10.1...
