Karina Lima

@simonyona.bsky.social et al show that quantify the ephemeral circulating lifespan of human cDC & propose functions of cDC & their precursors that are rapidly recruited to sites of #inflammation rupress.org/jem/article/...

📘 In Clinical #Immunology Collection: rupress.org/jem/collecti...
#FOCIS2025

The inhibitory receptor Siglec-E controls antigen-presenting cell activation and T cell–mediated transplant rejection Siglec-E negatively regulates innate immune responses and acute T cell–mediated transplant rejection in mice, offering a potential therapeutic target.

🚨 Our new study in @SciTranslMed identified the inhibitory receptor Siglec-E as a critical brake on dendritic cell activation and T cell–mediated transplant rejection. 1/4
www.science.org/doi/10.1126/...

The inhibitory receptor Siglec-E controls antigen-presenting cell activation and T cell–mediated transplant rejection Siglec-E negatively regulates innate immune responses and acute T cell–mediated transplant rejection in mice, offering a potential therapeutic target.

A study in @ science immunology shows that Siglec-E regulates dendritic cell's activation and and their ability to trigger T cell–mediated transplant rejection. www.science.org/doi/abs/10.1...

Muere a los 89 años el expresidente de Uruguay José ‘Pepe’ Mujica, el revolucionario tranquilo El exguerrillero y símbolo de la izquierda latinoamericana fallece tras una larga lucha contra el cáncer. Su carisma y su capacidad de ser un oráculo de la austeridad y la sencillez fascinaron al mundo

🔴 ÚLTIMA HORA | Muere a los 89 años el expresidente de Uruguay José ‘Pepe’ Mujica, el revolucionario tranquilo

The gates of Harvard University. The text reads: "Harvard Says It Will Not Comply With Trump Administration's Demands." Photo by Sophie Park for The New York Times.

“No government — regardless of which party is in power — should dictate what private universities can teach, whom they can admit and hire, and which areas of study and inquiry they can pursue,” Alan Garber, Harvard’s president, said about President Trump's demands. nyti.ms/4jzSS9W

Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse - Nature Communications Dendritic cells (DCs) induce infection-protective immune memory, which has yet to be exploited for cancer therapy. Here we show that type 1 DC vaccines quantitatively and qualitatively favors anti-tum...

Kudos to @sancholab.bsky.social and @swculek.bsky.social for this work in @naturecomms.bsky.social showing that "that cDC1-based vaccination excels at immune memory induction and prevention of cancer recurrence"
www.nature.com/articles/s41...

Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors Metallophilic marginal zone macrophages are positioned strategically within the spleen to process internalized blood-borne materials. Mauvais et al. find that these CD169+ macrophages cross-prime CD8+...

👉 When splenic metallophilic marginal zone macrophages do antigen cross-presentation equally well as conventional DC1. Congrats to the team of Peter van Endert from @inem-necker.bsky.social for this work published in @cp-immunity.bsky.social

www.cell.com/immunity/abs...

Kicking off our journey on BlueSky! We're excited to share updates and connect with you. Follow us and help us get the word out! For more information about the Center for Immunology, go to our website: immunology.umn.edu

In this review, Jana Raynor and Hongbo Chi highlight the signaling and functional effects of nutrients as Signal 4 in T cell–mediated immunity. rupress.org/jem/article/...

📘 In Tumor #Metabolism 2025: rupress.org/jem/collecti...
#KSTumorMetab25

Flyer for Massachusetts stand up for science, at the Massachusetts state capitol in Boston on March 7th from 12-4 PM. More info at standupforscience2025.org

HEY BOSTON! 📣☀️

MARCH 7TH, MASSACHUSETTS STATE CAPITOL!

Join us to #standupforscience2025 and make your voice heard!

SEE YOU THERE!

www.standupforscience2025.org #standupforscience20225

List of Science impacts: one month of Trump 2.0 20 January: Trump’s Day 1 executive orders 21 January: NIH activities suspended 27 January: Freeze on all federal grants 31 January: CDC databases disappear and papers are censored 2 February: NSF unfreezes funds, scrutinizes grants 6 February: Global health efforts imperiled 7 February: Cuts to NIH research overhead funding announced 14 February: Layoffs at US science agencies begin

A truly depressing article in #Nature listing of all the damage done to #science in the US by the Trump administration in just one month

💔 for so many friends and colleagues there

#solidarityforscience 🧪

www.nature.com/articles/d41...

Establishing the President's Make America Healthy Again Commission By the authority vested in me as President by the Constitution and the laws of the United States of America, it is hereby ordered: Section 1.

Is someone going to tell them that viral infections play an important role in the development of many chronic conditions, including asthma, autoimmunity, and cancer? 🧪🩺

“Your work is your rebellion” 💪

www.reddit.com/r/labrats/co...

CDC datasets uploaded before January 28th, 2025 by Centers for Disease Control and Prevention Topics cdc, government, united states, dataset, archive Language English Item Size 98.5G An archive of all CDC datasets uploaded to https://data.cdc.gov/browse before January 28th, 2025. Excludes corrupt datasets and data not publicly accessible.

The entire archive of all CDC datasets uploaded before January 28th, 2025 has been backed up on Internet Archive.

Incredible work everyone. Science will never be silenced!

Architects of immunity: How dendritic cells shape CD8+ T cell fate in cancer DC–T cell interactions during priming influence CD8+ T cell fate, and DCs subsequently sustain T cell responses against cancer.

A new #ScienceImmunology Review discusses the mechanisms through which dendritic cells influence cytotoxic CD8+ T cell responses against cancer. scim.ag/3PU7hRo

a man is holding an oscar statue in front of a hollywood sign ALT: a man is holding an oscar statue in front of a hollywood sign

“I'm Still Here” got 3 Oscar nominations.
Brazilians are mentalizing this today.

🇧🇷🇧🇷🇧🇷

It is dangerous and simply inexcusable to bury these reports. This information belongs to the public. As taxpayers, we pay for public health experts to research and compile all these reports so that we can have prompt and timely information about public health threats that could harm us.

Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic? Conventional dendritic cells (cDCs) are sentinels of the mammalian immune system that sense a wide range of danger and homeostatic signals to induce appropriately targeted T cell immune responses. Tra...

Appropriate that cDC2 programs are as complex as CD4 T cells. Job security.

"Current debates focus on whether the functional heterogeneity of cDC2s is shaped by ontogenically distinct subsets or by the adaptability of precursor differentiation in response to signals from the tissue." #ImmunoSky

David Lynch as Gordon Cole in Twin Peaks

RIP, David Lynch. Truly one of the great weirdoes in film and television history.

Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoidstructures in cancer https://www.biorxiv.org/content/10.1101/2024.12.27.628014v1

New year, new social network! Looking forward to connecting with other scientists!