A cytokine receptor–targeting chimera toolbox for expanding extracellular targeted protein degradation | PNAS Extracellular targeted protein degradation (eTPD) is an important new modality for manipulating the extracellular proteome. However, most eTPD rece...

Proud to be a co-author on this new PNAS paper from the Wells Lab.

Led by Kaan Kumru, this work expands the kineTAC platform into a versatile cytokine-based toolkit for cell and tissue-selective extracellular protein degradation—a major step forward for precision eTPD.

www.pnas.org/doi/10.1073/...

β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity - Molecular Neurodegeneration To define how Aβ pathology alters microglia function in Alzheimer’s disease, we profiled the microglia surfaceome following treatment with Aβ fibrils. Our findings reveal that Aβ-associated human micr...

Our new paper is out! Amyloid plaques switch on microglial GPC4, increasing neuronal tau uptake & toxicity—defining an amyloid→glia→tau pathway & a potential drug target. Pleasure to work with our collaborator @jcoutinhobudd.bsky.social. doi.org/10.1186/s130...

#Alzheimers #Glia #Tau #Amyloid