Karla Williams, PhD

Invadopodia-Mediated Remodeling of the Lymphatic Endothelium Drives Cancer Cell Lymphatic Dissemination and is Regulated by a CCR7-Vav2-Rac3 Signaling axis Cancer cell invasion across a lymphatic endothelial barrier and subsequent colonization of regional lymph nodes often marks the first stage of metastatic dissemination. Lymphatic vessels facilitate th...

More work coming out of the Williams lab. Could not wait to get it out, so here is the preprint on how cancer cells move into the lymphatic system and the importance of lymphatic metastases on global metastatic tumor burden:

www.biorxiv.org/content/10.1...

GABA–GABAA Receptor Signaling Orchestrates Invasion and Metastasis in Triple Negative Breast Cancer Cancer is a leading cause of death globally, with the majority of cancer-related deaths resulting from cancer metastasis −the process by which cancer cells disseminate to distant sites. To metastasize...

More work coming out of the Williams lab. Could not wait to get it out, so here is the preprint on how GABA drives cancer cell invasion in triple-negative breast cancer:
www.biorxiv.org/content/10.1...

Here, talented PDF Nikki Salmond, isolated extracellular vesicles from the plasma of breast cancer patients and healthy females. Using proteomics, we identified enolase 1 as a marker capable of detecting stage 1 breast cancer.
Thanks to CRS for funding this work.
@src-crs.bsky.social

Circulating enolase 1 as a diagnostic biomarker for early-stage breast cancer - npj Precision Oncology npj Precision Oncology - Circulating enolase 1 as a diagnostic biomarker for early-stage breast cancer

Our latest work, “Circulating enolase 1 as a diagnostic biomarker for early-stage breast cancer”, is now published in npj Precision Oncology!

www.nature.com/articles/s41...

Happy birthday, David Attenborough! 99 ways he has inspired us, by Barack Obama, Billie Eilish, Morgan Freeman – and many more This week the presenter turns 99. To celebrate, we asked 99 nature lovers – including Margaret Atwood, Jane Fonda, Bono, Kate Winslet and Michael Palin – how he has helped us see the world with fresh eyes

Happy birthday, David Attenborough! 99 ways he has inspired us, by Barack Obama, Billie Eilish, Morgan Freeman – and many more

National Letter Open Letter from Canadian Researchers to the Federal party leaders Click here to sign this letter See who has signed - version française se trouve à page 3 - Dear Party Leaders We, the undersigne...

Dear Canadian researchers, faculty, RAs, PDFs and grad students, this letter is for the federal party leaders asking them to defend and expand Canadian research sovereignty with a historic investment in science, please sign and share
docs.google.com/document/d/1...

Dr. Catharine Winstanley and Dr. Liisa Galea on why DEI is in everyone’s best interest:

"For decades, most biomedical research used only male subjects, particularly if model systems like cells or rodents were involved." 🧵⬇️

Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice Light scattering in biological tissue presents a significant challenge for deep in vivo imaging. Our previous work demonstrated the ability to achieve optical transparency in live mice using intensely...

Excited to share this collaborative work led by Guosong Hong’s group @stanfordneuro.bsky.social. A new method to render animals optically transparent for deep tissue imaging across the visible spectrum 🌈

www.biorxiv.org/content/10.1...

One More Time: Why Diversity Leads To Better Team Performance Discussions on diversity in the workplace can be heated and contentious. But the data still shows more diverse teams outperform their less diverse peers. Here's how.

www.forbes.com/sites/roncar...

Look who's here
@pnas.org ✔️
@science.org ✔️
@naturecellbiology.bsky.social ✔️
@natrevgenet.bsky.social ✔️
@naturebiotech.bsky.social ✔️
@naturemicrobiol.bsky.social ✔️
@naturechemistry.bsky.social ✔️
@genesdev.bsky.social ✔️
@cellchembiol.bsky.social ✔️
@genomeresearch.bsky.social ✔️
@jcellbiol.bsky.social ✔️