Dada Pisconti

I don't think AI is always bad, let's try to see it as a tool that can help us reach higher, rather than try to compete with it (also because if we compete, one day we'll lose)

Not everyone can hire a professional illustrator (well, I tried for years to get my talented artistic nephew to do it, but he wasn't interested).

I respectfully disagree. As always, in medio stat virtus. I got some help from AI to design my lab logo, I modified a bit what AI had originally produced which was a good start, and i like the final result.

Don't get me wrong, I always welcome an excuse to eat chocolate but... jeeez, have you looked at those effect sizes? seriously?

Look, this is a fascist gvt, and this guy is an incompetent fascist. But that gesture is being inflated. He was just pointing while talking, it's pretty clear.

Best exam answer, ever! 😆

There are no assays that measure the effect of disrupting WASF3 in vivo in a relevant animal model. There's one experiment, the treadmill, which says absolutely nothing about the kind of chronic fatigue experienced by patients with ME/CFS or Long Covid.

which is a very beautiful WASF3/mitochondria paper but not an ME/CFS or Long Covid paper, not even close. Moreover, in that paper they only show the effects of UDCA in cells, it's a long shot to give it to patients and hope it'll work. Wow!

But going back to the article, I can see why metformin was tested, it makes sense. Too bad it didn't work. I am not sure what the rationale for ursodeoxycholic acid was?

the most likely explanation is a combination of all these factors. but really the placebo effect is strong and shouldn't be discarded. That's why clinical trials should always be placebo-controlled (barring any practical issues with feasibility).

the original post has been deleted, likely for the best. Darn, now I am super curious to know what it was!

blows my mind away - 100% certainty used to occur up to 10%le, now only up to 5%le

The placebo effect is amazing, that's why lots of people believe in bogus medicine

With that said, of course there are biological reasons for histones to be present in serum at high enough levels to be detected, for example if there was lots of cell death. But I would expect that in that case we would have already solved ME/CFS as an autoimmune disorder. Except, we haven't.

The weakness is the same as for an immunoassay: just like no Ab-Ag interaction is 100% specific, same as aptamer-target. So, the hits that one gets with aptamers should be further validated with other methods such as immunoassays and mass spectrometry.

it's an array where the capturing molecules are aptamers, these are DNA molecules that bind to other molecules, such as proteins. From the biochemical point of view it is almost like an immunoassay, except that the capturing molecule is DNA instead of antibody (protein).

on the other hand this was not done with mass spec but with Somalogic, and I am always a bit suspicious about Somalogic findings

Ok, this new thing that the "grey area" proposals (Competitive Non Discussed) get bumped straight to Council without discussion, is total bonkers.

or 5 years of full time, all-year-round, daycare/preschool for 35,000 children (at an average pf $2k/month, though in some places is even much cheaper)

*were (lots of typos, I am a bit emotional...)

Agrado's Monologue (All about my mother - Almodóvar) YouTube video by SAINTDOG STREETWEAR

Dear Hon. Mace, we are only here on this Earth for a very short time, let's try and embrace the beautiful diversity of humanity and be all enriched by it. Embrace the rainbow and be at peace.

There, listen to Agrado and learn what authenticity truly is.

And you, Hon. Mace, when will you learn your lesson? When will you learn that granting other people their rights does not take anything away from you? When will you learn that feeding hate and intolerance can only bring you back hate and intolerance?

So, there you go, sex as a biological phenomenon is not a binary thing either.

Sex is not binary either, dear Hon. Mace. It's so complicated, at the biological level, that I can't even begin to explain it to you in a short social media thread (also because you don't seem to want to listen and learn) and, most importantly, we still do not fully understand it.

And how wrong I was, again!

I especially understood that womanhood is not a single "thing", it's a spectrum, like a rainbow. We call it gender, and we choose it, every day. But still I thought at least sex was clear and there were only two, clearly defined. I'm a biologist, you see, I thought I knew better.

Then I met great women who were not females and amazing females who were not women, and other wonderful people who didn't care whether they were females or women or anything else. They were just wonderful people. And I understood my lesson, I understood the difference between female and woman.

You see Hon. Mace, growing up I thought that female and woman where synonyms. 🧵

looks like vampire bite to me

$300 Million in jet planes lost to a fuckup.

That’s 83 five year NIH R01 grants burned in minutes due to error, aka poor execution of this unnecessary war which serves only to make the world more dangerous.