Umberto Aiello

Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

Postdoc positions available in my lab in Aarhus, Denmark on 'Mammalian Nuclear RNA Production and Turnover Systems'. Please get in touch for further information or simply apply here:
mbg.au.dk/en/news-and-...

🧬 The Department of Biology at @univ-amu.fr will soon recruit a lecturer in Molecular Genetics & Genomics (Eukaryotes).

🧪 Apply with an eligible team: Bertrand; Delacour; Kodjabachian; Libé-Philippot; Mann; Schaeffer; Thomas.

Details: lnkd.in/eFS8qQpU

Sequence-specific RNA recognition drives Restrictor-mediated termination of extragenic transcription Polizzese et al. show that the C3H1 zinc fingers (ZNFs) of ZC3H4 confer sequence-specific RNA binding to Restrictor. These ZNFs recognize a degenerate A/UGUA motif at ncRNA 5′ ends and are required for termination, whereas tethering of Restrictor to early elongating RNA Pol II depends instead on WDR82.

Online Now: Sequence-specific RNA recognition drives Restrictor-mediated termination of extragenic transcription Online now:

We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab.
@mrclmb.bsky.social

Please get in touch if you have any questions.
www.nature.com/naturecareer...

Ancient co-option of LTR retrotransposons as yeast centromeres - Nature Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

Our paper is now out in Nature:

“Ancient co-option of LTR retrotransposons as yeast centromeres”

www.nature.com/articles/s41...

A short thread on how retrotransposons helped give rise to yeast point centromeres.

1/14

Group Leader Call at the @cbitoulouse.bsky.social in
Genome biology, projects at the interface with devbio will be given particular attention. please share :)
cbi-toulouse.fr/wp-content/u...

Un poste de Professeur des Universités va être ouvert lors de la campagne d’emploi 2026 à l’université Claude Bernard Lyon1 -
Profil Recherche : Biologie Moléculaire des Eucaryotes.
Profil Enseignement: Biologie Moléculaire.
Profil ci-joint.
Merci de diffuser dans vos réseaux.

Research Group Leader Do you want to lead groundbreaking research in computational biology? Join us at EMBL-EBI! EMBL's European Bioinformatics Institute (EMBL-EBI) is seeking talented and highly-motivated scientists to jo...

We are hiring for group leaders again — EBI is a great place to start your research group!

embl.wd103.myworkdayjobs.com/EMBL/job/Hin...

We are hiring!

Hello world! I am excited to announce my lab is open at the University of Utah in the Department of Biochemistry. We are looking for scientists at all levels interested in studying host-virus interactions in both bacteria and animals. Come join us in beautiful Utah! (photo is 10 steps from lab)

#Post-doc position available in our lab at I. Curie, Paris Application and job details here:
emploi.cnrs.fr/Offres/CDD/U...

I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!

SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out!
www.biorxiv.org/content/10.1...

Looking to start your lab in generative biology / AI?
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty

A thread on our latest paper from the Whitehouse lab

Although the SGD website will be available over the next few weeks, SGD staff will be on winter break until Jan 5, 2026.

SGD wishes all of you, your colleagues, and your families a safe and restful holiday season. May your yeast grow robustly and your experiments be reproducible! 🧬🍻☃️

Hello everybody,
I am looking for an Engineer (IE) to help me start the lab at LBMC / ENS-Lyon in April.
We will investigate chromatin organization during replication in yeast.
RT appreciated!
To apply: inserm.softy.pro/offre/187863

@lbmcinlyon.bsky.social
#NewPI #3DGenome #chromatin #replication

How do new centromeres evolve while staying compatible with the division machinery?

Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.

👉 doi.org/10.1038/s41586-025-09779-1

A role for human senataxin in contending with pausing and backtracking during transcript elongation Han et al. use biochemistry and acute depletion of senataxin to reveal a role in RNAPII transcript elongation via reversal of pausing and backtracking. By contrast, senataxin has little direct effect on transcription termination.

Online Now: A role for human senataxin in contending with pausing and backtracking during transcript elongation Online now:

A mechanism of synergistic Mediator recruitment in RNA polymerase II transcription activation revealed by single-molecule fluorescence Single-molecule fluorescence microscopy studies by Zhou et al. show that transcription activator proteins bind at UAS/enhancer DNA and then sequentially or simultaneously recruit Mediator coactivator and RNA polymerase II to form an initiation complex precursor. Multiple DNA-bound activators synergistically enhance recruitment by binding to the same Mediator complex.

A mechanism of synergistic Mediator recruitment in RNA polymerase II transcription activation revealed by single-molecule fluorescence

Very excited and honored that our project CenAGE with @manellab.bsky.social and Elsa Logarinho was granted! Looking forward to discover how centromere instability affects the immune cells contributing to systemic ageing. More Info here: curie.fr/actualite/no... Open positions soon, stay tuned!

Legnini Group - Human Technopole Laboratory for Molecular and Systems Biology of RNA   The Legnini Group at Human Technopole combines molecular and systems biology approaches to study gene regulation. We use synthetic biology and opt...

1/6 We are hiring!!! 🐣🐣🐣
Fully funded postdoc position in my group!
humantechnopole.it/en/research-...

A developmental condensin I complex assists the Paramecium PiggyMac domesticated transposase during programmed DNA elimination Prokaryotes and eukaryotes use diverse strategies to cope with invading mobile genetic elements, including programmed DNA elimination (PDE). In the ciliate Paramecium , elimination of transposable ele...

🚨 Excited to share my first preprint on bioRxiv! 🎓 We uncover a non-canonical role of condensin I, beyond chromosome segregation 🧬
This work is the fruit of a collaboration between the @sandraduharcourt.bsky.social & @betermieri2bc.bsky.social labs!
➡️ doi.org/10.1101/2025...

Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods Nature Reviews Molecular Cell Biology, Published online: 06 October 2025; doi:10.1038/s41580-025-00895-4Co-transcriptional mRNA maturation is a complex, multistep process. This Review focuses on how the development of long-read sequencing methods enabled investigating the timing, coordination and outcomes of alternative uses of transcription start sites, splice sites and polyadenylation sites and their disease implications.

New Online! Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods

Collective challenges need collective solutions. Happy to share the insights we've gained from the way our cells handle this: www.nature.com/articles/s41... and its summary www.crick.ac.uk/news/2025-09....

Love RNA biology?

Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇).

PhD student/postdoc position co-supervised by Clemens Plaschka & myself.

DM or email us if you’d like to know more!

@vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social

5/ Please read more in the full preprint, and if you would like to scan your favorite protein, let’s talk!

Finally, huge thanks to @embo.org and @stanfordmedicine.bsky.social for their support! And to Lars Steinmetz and Kevin Roy for making this possible!

4/…but also surprising lethality in the CTD-interacting domain (CID), a region previously thought to be dispensable for viability!
CID mutants are lethal, yet don’t show transcription termination defects.
This hints at distinct mechanisms of dysfunction, perhaps aberrant complex formation

3/ As proof-of-concept, we scanned NRD1, an essential transcription termination factor.
We reached near-saturation mutagenesis with ~95% of residues edited.
We tracked mutational fitness and found clusters of lethal substitutions where we expected them (the RNA recognition motif)…

2/ Most proteins work through just a handful of crucial residues, but finding and interpreting them in essential genes is tough, since mutating them = lethality ⚰️
Our solution: combine multiplexed CRISPR editing with a repressible complementation system