Byron Lab

We are very happy to share our latest work exploring the role of newly synthetized integrin-α5 using RUSH. We found that a subset goes to the PM via unconventional secretion! Big thanks to all involved! Read more at doi.org/10.1083/jcb.... @mathildemathieu.bsky.social @martina-lerche.bsky.social

Airway macrophage specific expression of a dense glycocalyx and its remodelling following viral infection The glycocalyx is best studied for its regulation of immune cell trafficking from the vasculature into inflamed tissues. The glycocalyx is composed of a range of glycans and glyco-proteins that form a...

Delighted to share our new pre-print from PhD student Ziyun Zhang joint with @tracyh9494.bsky.social demonstrating that lung alveolar macrophages have a dense glycocalyx and interstitial macrophages do not, @mcrcellmatrix.bsky.social @lydiabeckeriii.bsky.social www.biorxiv.org/content/10.1...

🌍🌎🌏Open to students worldwide! I m super excited for this project 🎉

(BBSRC NWD) A novel redox mechanosignalling nexus in the synapse that is misregulated in neurodegeneration at University of Liverpool on FindAPhD.com PhD Project - (BBSRC NWD) A novel redox mechanosignalling nexus in the synapse that is misregulated in neurodegeneration at University of Liverpool, listed on FindAPhD.com

🧠 Fully funded 4-year PhD studentship 🧠 Please repost

BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social

Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin.

www.findaphd.com/phds/project...

MRC Doctoral Training Partnership Find out more about the Medical Research Council (MRC) Doctoral Training Partnership (DTP) studentships for postgraduate researchers undertaking PhDs in biomedical, clinical and health services areas.

Two days left to apply for a Medical Research Council-funded PhD opportunity in the lab. This is a student-led project, so you can work with us to develop an exciting project in a research area of mutual interest! www.bmh.manchester.ac.uk/study/resear...
@mcf-uom.bsky.social @fbmh-uom.bsky.social

Cake topped with icing, sprinkles and jelly beans to celebrate great presentations by Byron Lab members!

Fantastic talks from the lab at this week's @mcf-uom.bsky.social Lab Showcase - well done Josie, Julio and Morgan! Calls for cake 🍰

Happy to share that my PhD has finally taken the shape of a paper! ✨

Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.

🧵👇

Member of the Byron Lab relaxing after work.

Member of the Byron Lab relaxing after work.

MSc student Sylvia and honours project student Jess Osborn recently completed their projects in the lab. And this time last year, we said farewell to MSc student Yue Li and honours project student (and then intern) Isobel Gall.

Wishing you every success in your next steps 👏

@fbmh-uom.bsky.social

Shoutout to our fantastic project and masters students! 🧪✨

It was a pleasure to have you in the lab @mcf-uom.bsky.social – your energy and hard work truly made a difference! 💫

#LabLife #CellBiology #ResearchStudents #ThankYou #AcademicLife @fbmh-uom.bsky.social @manchester.ac.uk

Computational image analyst (m/f/d) The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

A school of scientists swimming in the Adriatic Sea on a sunny day, with the greenery of the Dalmatian coast in the background.

Excellent science, inspiring discussions … and scientists in the sea!

Special thanks to Andreja, @bengoult.bsky.social, Vasso, Nina, Marina and Marija for organising such a great meeting! 🐬 🐬

Fantastic time at the Adhere2 conference on cell adhesion - on the lovely Dalmatian coast.

#CellBiology #research #conference

Queen Mary University of London

Very enjoyable visit to the @qmbci.bsky.social yesterday, discussing fantastic science and presenting our work 🔬
Thank you for warmly hosting, @tysonsharp.bsky.social! @susanagodinho.bsky.social @drtanyasoliman.bsky.social
@cruk-cityoflondon.bsky.social
@qmul.bsky.social
#research #collaboration

New £50m MRC Centre to study how environmental exposures cause chronic inflammatory diseases The environment is increasingly acknowledged to play a critical role in our risk of developing diseases, with 30,000 deaths attributed to air pollution alone in the UK each year. A new research centre...

A new £50m Medical Research Council Centre is set to study how environmental exposures cause chronic inflammatory diseases.
www.manchester.ac.uk/about/news/n...

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…

Excited to share our most recent study on #integrintraffic #cancer #migration #focaladhesion by @ivaskalab.bsky.social @drpaulinamoreno.bsky.social Niklas Jäntti et al www.sciencedirect.com/science/arti...

We're Hiring: Postdoctoral Position in Cross-Linking Mass Spectrometry

Join our team at the Center for Structural Mass Spectrometry at the Martin Luther University Halle-Wittenberg (Sinz Lab) to develop and apply cross-linking mass spectrometry techniques for studying protein interactions.

Research Associate in Synthetic Chemistry and Chemical Biology:Oxford Road

Delighted to advertise a collaborative postdoc position available in the lab to develop new proximity labelling tools, funded by a BBSRC Transformative Research Technology grant:

www.jobs.manchester.ac.uk/Job/JobDetai...
#ChemicalBiology #SyntheticChemistry

Big thanks also to the @manchester.ac.uk @fbmh-uom.bsky.social School of Biological Sciences Internationalisation Award for supporting the visit to build exciting collaborative research networks 🌍
Looking forward to what's next 💡

Several members of the Tumor Immunology and Immunotherapy team from the Regina Elena National Cancer Institute in Rome gathered around a table.

Just back from a fantastic research visit to the Regina Elena National Cancer Institute, Rome, working with Dr Paola Nisticò and the Tumor Immunology & Immunotherapy team 🔬
Amazing cancer biology research, inspiring discussions and such warm hospitality from the team ☀️
#CancerResearch #Collaboration

Had a chat with @ajbrenes.com at #BSPR2025 about data reuse, and how some datasets, once combined and reused for a new biological question, are absolute gold. It's always worth depositing your data. 💿

Here are the statistics of his #HipSci dataset, which has remained at 2% after 6 years. 📈

A computational pipeline for spatial mechano-transcriptomics - Nature Methods The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.

🚨 Paper Alert 🚨
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...

Free Hands-On Training in Mass Spectrometry Imaging (MSI)!
A unique training opportunity in MSI, open to both national and international attendees in collaboration with BMSS and catapult. For more information please check this link: www.bmss.org.uk/meetings/bms...

Bioinformatician, apply by 31 March text overlaying image of IGC building

Do you want to play a pivotal role in groundbreaking research at IGC? In this role you will work at the intersection of computational and experimental science, leveraging cutting-edge technologies to address fundamental questions in genetics and disease.
Apply by 31 March: edin.ac/3R5dEBU

Happy to share our new publication in
@naturematerials.bsky.social
on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉
www.nature.com/articles/s41...

Measuring and manipulating mechanical forces during development - Nature Cell Biology This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...

Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...

It’s #BritishScienceWeek and our researchers, academics and students have been at Manchester Museum!

Students from far and wide, alongside the general public and visitors to the museum, have been finding out about the exciting work going on in the Faculty @officialuom.bsky.social.

Come and find out how the Protein and Metabolite Analysis group can support your research at the Protein and Metabolite Analysis 2025 Showcase!

📅 31 March 2025 | 🕒 9am - 3:00pm
📍 Michael Smith Building Lecture Theatre

Register here: www.eventbrite.co.uk/e/protein-me...

@the-node.bsky.social #biologists100 reporter @jens-cells.bsky.social is putting together a conference survival guide. What are your top tips for getting the most out of your conference experience.

Unique opportunity to join the CytoMorpho Lab (in Paris ❤️) as a postdoc to work on the self-organization and polarization of reconstituted networks made of microtubules, motors and actin filaments in vitro. Experience required.
Please Repost 🙏 thanks !

"Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties" and are distinct from other large EVs both in their content and morphology. This video shows a blebbisome (magenta) in the same field of view as forming migrasomes (yellow).
www.nature.com/articles/s41...