Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6...
Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet
Across evolution, lipids tell a story🧬
🖊️famous #reviewer2 quotes "... highlights how lipidomes have specialized many times over the course of evolution and emphasizes the importance of adopting a 'lipid-centric view' in biochemistry, cell biology, and evolutionary biology..."
Do #lipids carry the signatures of #evolution?🤔
In #Biochemistry Perspective, We 'provocatively' (as my former PhD guide & scientific guru Sankar put it ) propose an expanded view of the classic “lipid divide” idea
feedback/critiques all welcome 🙌 #lipidtime
pubs.acs.org/doi/10.1021/...
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
This composition is a tribute to the legendary Bill Jacobs, who isolated the Bxb1 phage-aka the 'Bronx Bomber'-from the dirt in his backyard in the Bronx, NY. 🦠🏠🗽
A true classic in #phage lore! #tuberculosis
#NotTheCover @cellpress.bsky.social ...but, we’re still pretty proud of it! 😄 Had an awesome time putting this together with the amazing @kfreeman.bsky.social and @raphaelpark.bsky.social What a ride! 🚀
#SciArt #CryoET #CryoEM
Paper👉 www.cell.com/cell/fulltex...
The very first structural images of a tuberculosis-fighting virus
New insights could advance phage therapies for the world’s deadliest bacteria—including drug-resistant strains.
www.scripps.edu/news...
@science.org 🧫🧬❄️🔬 Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis | Science www.science.org/doi/10.1126/...
@yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase
Scripps Research and @pittofficial.bsky.social capture the first cryo-EM & cryo-ET images of a virus infecting TB-causing Mycobacteria, revealing an unexpected infection mechanism that could inform phage therapies for drug-resistant TB, per @cellpress.bsky.social.
Some eye-catching #TeamTomo work here. Congrats to @kfreeman.bsky.social and all the authors! 🧪🧶🧬🔬
Host invasion by a mycobacteriophage—visualized in action! 🦠✨
Thrilled to have contributed to this exciting work! Great collaboration with the amazing Krista @kfreeman.bsky.social & Graham Hatfull lab. Huge thanks to the Park lab for this fantastic opportunity 🙌 #CryoEM #CryoET #phage #mycobacteria
Had an amazing week at the Gordon Research Conference on Biology of Mycobacteria! Great chats, exciting posters and the chance to meet both legends in the field and awesome new peers…
#mycobacteria
