Chloe Slichter

CAR-T therapy provides relief for children with autoimmune diseases Nature - Symptoms and organ damage abated in young children and teenagers whose conditions had resisted other treatments.

CAR-T cell therapy seems to have reset the immune system and eased severe symptoms in eight children and adolescents with autoimmune disorders

go.nature.com/4rsFlFx

Great thread with tons of resources:

Bystander intervention is one of many ways to support our communities. I’ve signed up & if you’re interested you can sign up here - many time slots available:

I signed up for "Bystander Intervention to Support the Immigrant Community" training on Friday from 12-1 ET here. There are other sessions in the coming days also.

righttobe.org/training/bys...

World’s first personalized CRISPR therapy given to baby with genetic disease Treatment seems to have been effective, but it is not clear whether such bespoke therapies can be widely applied.

To be clear, these kinds of breakthroughs are going to come to a screeching halt with the current NIH funding cuts. This new treatment is only possible because of decades of basic research. What might be possible 20 years from now if we don't destroy basic research?

www.nature.com/articles/d41...

Opinion | Why Did Elon Musk Go After Bunkers Full of Seeds? (Gift Article) Gene banks are like a survivalist cache: our nation’s safeguard against all future challenges to growing the food we need.

Seed and tuber collections are really, really, REALLY important.

A short thread 🧵 1/5

🧪 #plantscience

Beautiful day for a snowshoe break in between scientific sessions at the Immune Cell Therapies: Advances in Cancer and Autoimmune Disease Keystone Symposia in Banff. Great snow & even better science! #KSCellTherapy25 @keystonesymposia.bsky.social

This is a list of blockbuster drugs in 2024. Guess how many can trace their origins to NIH funded research?
All of them.

Why and How Vaccines Work Vaccines save millions of lives from infectious diseases caused by viruses and bacteria. As the world awaits safe and effective COVID-19 vaccines, we celebrate the progresses made and highlight challe...

- How and Why Vaccines Work: From @virusesimmunity.bsky.social @saadomer.bsky.social www.cell.com/cell/fulltex...

Great study by the Rezvani lab exploring the relationship between the immunological synapse and NK-CAR function in response to AML. One outstanding question - with a CD38 CAR, how many cord-blood derived CAR-NK cells are undergoing fratricide? A CD38 KO could preserve NK #s and enhance NK function.

Meeting report @sciimmunology.bsky.social
challenges to understanding common mechanisms in autoimmune disease
www.science.org/doi/10.1126/...

Science’s 2024 Breakthrough of the Year is lenacapavir, an injectable drug that demonstrated remarkable success at preventing HIV infection with one shot every 6 months. The drug attaches to the lattice-like capsid proteins that shield the virus’s genetic material—a mechanism that could inspire other antivirals. Lenacapavir could help end the HIV/AIDS epidemic, but that will hinge on access for those who need it most.

Science’s 2024 Breakthrough of the Year is lenacapavir, an injectable drug that demonstrated remarkable success at preventing HIV infection with one shot every 6 months.

Learn more about this year's #BOTY and other big advances in science: scim.ag/3BrCtUn

MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection IL-17A–secreting MAIT17 cells can convert to IFN-γ–producing MAIT1 cells, boosting protection against microbial infection.

It’s been years since I last worked on MAIT cells in my thesis lab at @fredhutch.bsky.social but I still love reading about them: www.science.org/doi/10.1126/...

Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy
www.cell.com/cell-stem-ce...

The science behind winning a Nobel Prize? Being a man from a wealthy family | Torsten Bell A lot of talent is wasted in a world where more than half of laureates come from households in the richest 5%

"If talent and opportunity were equally distributed, the average winner would come from a middle income background.

The reality?

The average laureate grew up in a household just below the top 10%. More than 50% come from the top 5%"

By Torsten Bell

www.theguardian.com/commentisfre...

Fascinating study where they label CAR T cells and follow their trafficking in patients! Immediate biodistribution is to the liver and spleen, and they can see whether the Car goes into extramedullary masses. What explains differences between patients?

Good morning from Philadelphia ☀️ Here for the Cell Therapy for Autoimmune Disease Summit. Looking forward to learning more about the application of synthetic biology in autoimmunity #celltherapy